Aurelien Justet

151 posts

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Aurelien Justet

Aurelien Justet

@AurelienJustet

Katılım Temmuz 2019
409 Takip Edilen91 Takipçiler
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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
Biomechanics and single cell sequencing analyses reveal mechanisms and biomarkers of decreased exercise ability with aging. Kudos @ruben_deman & Dr. Manning for integrating physiology, single cell biology, aging, vascular biology so elegantly!! onlinelibrary.wiley.com/doi/10.1111/ac…
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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
Reall cool paper from the Super Team of Jonas Schupp: Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis #CureSarcoidosis academic.oup.com/ajrccm/article…
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Maor Sauler
Maor Sauler@maorsauler·
Excited to share this work, now out in @NatureGenet . There is no cure for #COPD. To tackle this challenge, we performed nuclear sequencing, spatial transcriptomic, and proteomic analysis of lung tissue from 141 subjects to better understand this disease. #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…
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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
Always a pleasure to see the paper come out in print & this one is very special because it indicates how Pulmonary Fibrosis drug discovery can be liberated from Col1A1, ASMA, using AI, human & PCLS scRNAseq data Kudos @ZYM980202 @johnding86 #CurePF4ALL nature.com/articles/s4155…
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Yuuuuuuuuuuuumin@ZYM980202

1/n Happy to share our new single-cell+unsupervised AI drug discovery method is now published in Nature Biomedical Engineering!🚀 Huge thanks to @johnding86, @KaminskiMed and all collaborators. 🎉 We hope UNAGI can accelerate the discovery of new drugs. doi.org/10.1038/s41551…

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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
As one of the authors of this perspective, I can only say: I wish there was no need to write it. But sadly, there was. I'm grateful @NEJM broke the American Medical Establishment's wall of silence and published two perspectives about Gaza. Let's hope more action follows 👇🏼
NEJM@NEJM

The authors of a new Perspective essay write that in the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic famine caused by the devastation, U.S. physicians have an ethical obligation to respond and support immediate changes. Read the full Perspective: nej.md/4ns9yCi

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Tech Educator
Tech Educator@tech_educator·
Data Analysis depends on Stats. Introducing "Think #Stats: Exploratory Data Analysis "PDF. • Save 100+ hours on research And for 48hrs, it's 100% FREE! To get it, just: • Like and retweet • Comment " data " • DM me in the message for the link
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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
🙏🏼👏🏼🙏🏼 Drs Zheng, Schupp, Adams, Clair, Justet, Ahangari, Yan, Hansen, Carlon, Cortesi, Vermant, Vos, De Sadeleer, Rosas, Pineda, Sembrat, Königshoff, McDonough,Vanaudenaerde, Wuyts & Ding for this amazing #AI2CureIPF collaboration!! nature.com/articles/s4155… and 🧵below 👇🏼
Yuuuuuuuuuuuumin@ZYM980202

1/n Happy to share our new single-cell+unsupervised AI drug discovery method is now published in Nature Biomedical Engineering!🚀 Huge thanks to @johnding86, @KaminskiMed and all collaborators. 🎉 We hope UNAGI can accelerate the discovery of new drugs. doi.org/10.1038/s41551…

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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
The Unagi paper is FINALLY out! We present the first application. of a novel AI tool to human pulmonary fibrosis snRNAseq data to identify cellular trajectories & reversak perturbations with proteomics & PCLS validations!! See 🧵 👇🏼 and paper here nature.com/articles/s4155…
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Yuuuuuuuuuuuumin@ZYM980202

1/n Happy to share our new single-cell+unsupervised AI drug discovery method is now published in Nature Biomedical Engineering!🚀 Huge thanks to @johnding86, @KaminskiMed and all collaborators. 🎉 We hope UNAGI can accelerate the discovery of new drugs. doi.org/10.1038/s41551…

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Yuuuuuuuuuuuumin
Yuuuuuuuuuuuumin@ZYM980202·
6/n We benchmarked UNAGI against both conventional DL methods (e.g., scVI) and single-cell foundation models (scGPT, Geneformer). UNAGI outperformed them in cell-embedding generation, disease-associated marker/pathway identification, and in-silico drug perturbation.
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Yuuuuuuuuuuuumin
Yuuuuuuuuuuuumin@ZYM980202·
5/n We evaluated the generalizability of UNAGI using a COVID-19 dataset. And UNAGI successfully 1) reconstructed the cellular dynamics of COVID19 and 2) re-discovered some compounds that have anti-COVID19 effects supported by existing literatures. #covid19
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Yuuuuuuuuuuuumin
Yuuuuuuuuuuuumin@ZYM980202·
4/n Thanks to @KaminskiMed and his team, we validated one of the UNAGI's prediction, Nifedipine, a common medication to treat high blood pressure, has the similar anti-fibrotic effects as Nintedanib in the human Precision-Cut Lung Slices. #ipf #singlecell
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Yuuuuuuuuuuuumin
Yuuuuuuuuuuuumin@ZYM980202·
3/n UNAGI can conduct perturbation on the pathway and drug/compound levels. When applied to the IPF data, we identify a full spectrum of pathways drug/compounds from well established to less studied ones. e.g. We re-identified Nintedanib, the FDA approved drug for IPF.
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Aurelien Justet retweetledi
Yuuuuuuuuuuuumin
Yuuuuuuuuuuuumin@ZYM980202·
2/n We applied UNAGI to a time-series snRNA-seq Idiopathic Pulmonary Fibrosis (IPF) dataset and successfully reconstructed (1) the temporal dynamics graph (panel A) to describe the IPF progression (2) cellular dynamics (panel B and C) of individual cell tracks. #singlecell #IPF
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Aurelien Justet retweetledi
Yuuuuuuuuuuuumin
Yuuuuuuuuuuuumin@ZYM980202·
1/n Happy to share our new single-cell+unsupervised AI drug discovery method is now published in Nature Biomedical Engineering!🚀 Huge thanks to @johnding86, @KaminskiMed and all collaborators. 🎉 We hope UNAGI can accelerate the discovery of new drugs. doi.org/10.1038/s41551…
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James D Chalmers
James D Chalmers@ProfJDChalmers·
The new European Respiratory Journal impact factor is 21. Ranked #2 across all resp journals Thank you to the incredible @donsin4 , all authors, our outstanding editors and journal staff ♥️ @ERSpublications @EuroRespSoc IF for selected respiratory journals below
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Keşfet

@atscommunity @YalePCCSM @UMich @COPDFoundation @GOLD_COPD @ruben_deman @NatureGenet @ZYM980202