Charles Bayly-Jones

We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s4158… 🧵

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Here's a little preview. Check out the manuscript for an unexpected finding!! doi.org/10.1016/j.cell…

Sometimes projects have a particular hurdle - this project had an avalanche. Every stage of the investigation was tough; cloning, purifications, freezing, analysis, function. This figure highlights the #cryoEM analysis.

Absolutely thrilled to see our latest study online @CellCellPress. Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex. doi.org/10.1016/j.cell… @LuptonCJ @Dr_MLHalls & Andrew Ellisdon. #cryoEM #KICSTOR #mTORC1 #GATOR1

Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category. This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉 Photography and video: @vicgovau.bsky.social

Monash just got a huge upgrade - How a $60m computer called MAVERIC could change Australia’s AI future afr.com/technology/how…

@bluesocks81 DeepSeek and Jaycar for the win... 🤣

First step in the design of our new cryoEM sample prep project is well and truly underway! Mate, Raspberry Pis are so much fun!

Amidst the chaos, here's a belated but exciting highlight on the recent LYCHOS structure by @bj_charles @LuptonCJ @Dr_Ellisdon @Dr_MLHalls @RobertoZoncu and I broke down their findings, explored future directions, and tackled the key remaining questions. authors.elsevier.com/c/1kZRC3SNvcEP…

The next nuclear reactor to be prematurely closed in Europe turns off February 15th, in the dead of winter.

The first major body of work from my PhD is now up on BioRxiv! We used AI-designed binders to block the uptake of heme from hemoglobin through ChuA, a heme transporter found in pathogenic E. coli. 🦠🩸🔬 I’m very grateful for my supervisors and all coauthors for their support!

@chaidiscovery I'm come across a rather perculiar behaviour. Chai1 correctly models a complex fold when provided Cα-Cα constraints (as little as 2% work) with use_esm_embedding=False. However if I alter the sequence by even a single residue, the prediction fails... Any insight?

@JhonatanReales @LuptonCJ @ScienceAdvances @sci_laura @Dr_Ellisdon Many thanks! It has been a long project in the making...

@LuptonCJ @ScienceAdvances @bj_charles @sci_laura @Dr_Ellisdon Great job! Congrats

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex in @ScienceAdvances! Awesome effort from co-authors @bj_charles and @sci_laura with @Dr_Ellisdon doing the heavy lifting leading the project. science.org/doi/10.1126/sc…

@allostericstate @MonashBDI @MonashUni @CryoEM_Monash @HariVenugopal2 Thanks TJ - it certainly wasn't. We learnt the hard way that TSC is also quite prone to denaturing due to AWI issues and freezing. Not a trivial problem 😅 but we persevered and had fun!

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances . Equal-first co-authors @LuptonCJ & @sci_laura. Work lead by @Dr_Ellisdon. Funding from @DeptofDefense & @arc_gov_au. science.org/doi/10.1126/sc…

@AlboMP Bad idea, bad policy. Focus on the things that matter - climate change, underfunded hospitals, tax inequality, housing crisis.

TODAY: We're introducing our bill to make 16 years the minimum age for social media.

Work done @MonashBDI @MonashUni using our amazing @CryoEM_Monash facility. As always @HariVenugopal2 is indispensible to our success!

Finally TSC is extraordinarily flexible and is a massively difficult structural biology target. We had to use all the tricks we know to get this one... Parts of TSC can move by up to 10 nm!!!

@structureltp @ScienceAdvances @LuptonCJ @sci_laura @Dr_Ellisdon @DeptofDefense @arc_gov_au Thanks! It seems the field is exploding with structures recently.

@bj_charles @ScienceAdvances @LuptonCJ @sci_laura @Dr_Ellisdon @DeptofDefense @arc_gov_au Fantastic work, congrats!