

Harry Giles
1.3K posts

@Beandoc2
Nephrologist (kidney doc) with a passion for kidney advocacy and especially home dialysis




As a medical school professor, I teach about APOE4 -- the gene that makes you 2.5x more likely to develop Alzheimer's. We've told patients there's nothing they can do about it. A new JAMA Network Open study of 2,157 adults just proved us wrong. Higher meat consumption completely abolished the APOE4 dementia risk. The data: -> APOE4 carriers with highest meat intake: 55% lower dementia risk -> Their typical 2.5x excess Alzheimer's risk? Gone entirely -> Cognitive decline reversed: +0.32 standard deviations over 10 years -> Unprocessed meat was protective; processed meat was harmful regardless of genotype Researchers propose APOE4 is an evolutionary adaptation to meat-rich diets. The gene isn't a defect -- we just stopped feeding it correctly. This is personalized metabolic medicine. Your genes load the gun, but your diet pulls the trigger -- or puts the safety back on. Full breakdown coming on the Health Longevity Secrets podcast. Source: jamanetwork.com/journals/jaman… #APOE4 #Alzheimers #MetabolicHealth #Nutrition #HealthLongevity







#KidneyQuiz Which of the following membranous antigens has been recently identified and associated with underlying malignancy? #nephX #kidneypath #pathX #nephtwitter




