Bechara Kachar

New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do. rdcu.be/emtQu #CryoET #MembraneBiogenesis #Organelle 🧵1/5

Excited to share our latest work, led by Saman Hussain and Miloslav Sedlacek, who uncovered spontaneous Ca²⁺ transients in stereocilia — a discovery that offers fresh insight into MET channel behavior Full story: nature.com/articles/s4159… #neuroscience #haircells #calciumimaging

Meet the ‘hemifusome’: A newly discovered vesicular organelle complex with a unique membrane topology. Could it play a role in protein and lipid sorting, recycling, and intraluminal vesicle formation? @IRPatNIH @BecharaKachar @NatureComms paper: brnw.ch/21wUdrP

“Scientists discover unknown organelle inside our cells” Each new discovery changes how we perceive pharmaceuticals and toxins impact life. Science is about accepting we only know small parts of a complex system. phys.org/news/2025-06-s…

5/5 This study rdcu.be/emtQu was made possible by a fantastic team: @amirrasoultav and @HuShiqiong @NIH and @sehamebrahim @UVA

4/5 We propose an ESCRT-independent mechanism for intraluminal vesicle and multivesicular body (MVB) formation. Via PND-driven vesicle generation, hemifusion, and internalization, hemifusomes act as hubs for building complex MVBs - no ESCRT machinery required.

New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do. rdcu.be/emtQu #CryoET #MembraneBiogenesis #Organelle 🧵1/5

From stem cell to structure- This human colonoid shows the self-organization of intestinal epithelial cells in 3D—nuclei in magenta, actin in green. A living miniature gut for your #FluorescenceFriday.

🧫 A gentle reminder that your gut is an actual work of art. #FluorescenceFriday #BeneathTheScope

Scientists in the @Alushin_Lab have figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for metastasis. #RockefellerScience bit.ly/3PKErmA

A spectacular sight 1225m (4019 ft) beneath the waves off Baja California as EVNautilus encounter the amazing Halitrephes maasi jelly.

Our latest paper is out and we have just released an update of CryoVesNet code for automatic segmentation of synaptic vesicles github.com/Zuber-group/Cr…. It now includes a Pyto wrapper to easily segment tethers and connectors. A lot of credits to @AmeeeeNeuro. #TeamTomo

First short article on the CZII CryoET Data Portal: nature.com/articles/s4159… Comments/feedback welcome.

Pleased to present our latest work, where we show that the cell-cell adhesion protein afadin coopts mechanically-regulated elements of the cadherin-catenin complex to drive cytoskeletal engagement. biorxiv.org/content/10.110…

Crosstalk between mitochondria–ER contact sites and the apoptotic machinery as a novel health meter: Trends in Cell Biology cell.com/trends/cell-bi…

Scientists at EMBL Heidelberg and @UVA have discovered a new adaptation to starvation in yeast, in which ribosomes attach to the mitochondria in an upside-down position. The findings might provide insights into how cancer cells survive under stress. embl.org/news/science-t…

Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out @NatureComms! A collaboration between @medicineUVA, @EMBL, @EmblImaging, MEMC. Congrats to all authors! nature.com/articles/s4146…

Cytoplasmic ribosomes hitchhike on mitochondria to dendrites biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Standing room only for the first ACB-Physiology combined seminar series given by Dr Ebrahim from @UVA. She educated us on how the cytoskeleton uses mechanical forces to regulate cell secretion to reproduction. Outstanding! @ECUBrodySOM @ECUResearch @ECUOFE @LabGeyer