Beth Osia

So happy to see the final chapter from my PhD published in NAR! We used our yeast BIR system to investigate mutagenic ssDNA formed during BIR synthesis in the context of APOBEC-inflicted DNA damage and DNA hairpin-forming inverted repeat sequence. 1/4 doi.org/10.1093/nar/gk…

Check out our latest pre-print: we show that the LINE-1 retrotransposon is a potent source of chromosomal rearrangements and instability in addition to insertional mutagenesis using shotgun and long-read WGS. @KathleenHBurns @JenniferAKarlow biorxiv.org/content/10.110…

@ginibh31 Thank you, Ragini!

@BethOsia Congratulations, Beth!!!

Paper accepted on Halloween! 🎃🐈‍⬛👻 Gonna celebrate with spooky movies and candy!

@Zeniticist Thanks, Zenith!

@BethOsia Congrats, Beth!

@HannahTrost1 Thanks, Hannah!

@BethOsia Congrats Beth!!

@PietroPichierri Thank you, Pietro!

@BethOsia Congratulations Osia! Well deserved!

Grad students and postdocs!! Please join us at the 2025 @GordonConf GRS on Mammalian DNA Repair on Feb 1-2 with @LabLegube as our keynote speaker! Talks selected from submitted abstracts Register here: grc.org/mammalian-dna-…

🧬Super excited about this new pre-print from my PhD work focusing on the role of PAXX and MRI during chromosomal EJ! 🧬 #CNHEJ #DNAendsynapsis

Our first Postdoctoral Association (PDA) Happy Hour event was a total success thanks to all the postdocs, staff scientists, grad students and some @cityofhope research community members who joined us. 🙌 Stay tuned for our next event! #pda_coh #postdoclife #coh

@JorgeMorenoPhD @R_Mallarino Congrats, Jorge! This is amazing work!

YAYAYA I did a thing! My first-first author paper is now out! So happy and proud thinking of all the time, brain power, and coffee that went into this. Of course all this work could not be possible without collaborators, friends, and @R_Mallarino's guidance!

Now online! APOBEC3A and APOBEC3B drive distinct mutational landscapes in tumors. We showed how A3A and A3B substrate preferences for different hairpin structures can be exploited to identify patients' tumors with mutations caused by either A3A or A3B. nature.com/articles/s4146…

Happy to share the updates of my research at this amazing meeting and represent my institution @cityofhope #ENDO2024 @theendocrinesociety

A monumental work by many in my lab and @PCF_uiowa , and another wonderful collaboration with @PietroPichierri and his team! A double-ring of human RAD52 remodels replication forks restricting fork reversal biorxiv.org/content/10.110… @MortezaaliRazza @n_schnicker @LokeshGakhar

This is finally out! And it is AWESOME! nature.com/articles/s4158…

Things that keep me up at night.

Chromoscope is now published in @NatureMethods! Chromoscope is open-source and well-documented. Try it out on example/your data and share your feedback! @sehi_lyi @peter_j_park @ngehlenborg @trevmanz @chromoscope_bio #CancerGenomics

Happy to share our newest paper by @anastasiamhale and @Ashna_Dh in @NatureComms : "Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases". rdcu.be/dnXjJ

A second example of a DDR factor that associates with Okazaki fragment. 53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication biorxiv.org/content/10.110…

Glad to share our latest work published in @NatureComms, where we we discover the existence of evolutionary signatures of cancer characterizing patients with similar prognosis and study their implications for predicting cancer progression and outcomes. nature.com/articles/s4146…

Antibody technologies are evolving. So is #DSHB. For almost 40 years, it’s been our mission to preserve and reliably reproduce essential reagents at accessible prices. To better serve the research community, we’re making some changes. We hope you’ll grow with us. 🧫