The Bianchi Lab

Our paper in @ScienceAdvances. The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans #aging #Huntington #stress #alkalinity #glia #autophagy #ionchannel #pH science.org/doi/10.1126/sc…

NIH-funded researchers found more than 1,000 odor-detecting receptors in mice and uncovered a previously unrecognized organizational structure involved in the sense of smell. These findings may inform new approaches to treat loss of smell. Learn more: bit.ly/4fu6TqH

How membranes shape up for lipid transfer elifesciences.org/articles/11137…

Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions aging-us.com/article/206375…

Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation: nature.com/articles/s4146…

α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron–microglia communication: nature.com/articles/s4146…

AMPK: a master regulator of mitochondrial quality and quantity dlvr.it/TSWkL5

The #neurotransmitter known as #GABA most often acts as the #brain's braking system. In a new study published @NeuroCellPress, @YaleNeuro researchers say GABA may sometimes act as a gas pedal instead, enhancing neuronal activity: bit.ly/4ty7tqK

Inside Nobel laureate @ardemp's lab, graduating PhD student Nick Villarino is developing new ways to visualize how the body senses touch, pressure and stretch. At the @ScrippsGradPrgm, his work maps sensory signaling pathways throughout the body. 📸 - Stephen Yuan

Lifespan extension from fasting depends not on sustained activation of lipid catabolism, but on its silencing upon nutrient replenishment. @NatureComms

Mutations in the SHANK3 gene are associated with autism spectrum disorder, which is often linked with sensory abnormalities. A new study shows that SHANK3 mutations disrupt odor processing in the brain, helping explain altered responses. scim.ag/4dpypEe

Neurons maintain whole-body energy balance by storing fat within specialized structures called lipid droplets, a mechanism confirmed across both invertebrate and vertebrate species. nature.com/articles/s4225…

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging nature.com/articles/s4146…

The naked mole-rat microbiome is associated with healthy aging and social structure dlvr.it/TS8g3D

Online now: Astrocyte cell volume dynamics across cortical states and transitions dlvr.it/TS7SZ6

Online now: A reciprocal glial circuit calibrates injury information and governs the tissue response balance dlvr.it/TS3Fsm

In their Review, Baicong Mu and Dan Zhang @JessieZhangsg discuss how membranes function as mechano-chemical integrators, coupling lipid properties, protein effectors & Ca2+ signalling to sense stress, remodel membranes & activate repair pathways. journals.biologists.com/jcs/article/13…

Exercise induces sex-specific assembly of mitochondrial supercomplexes dlvr.it/TRwKfn

The findings of this one indicate that the electron transport chain complex organization can be modulated by exercise and that the mitochondrial supercomplex assembly in human skeletal muscle appears to be regulated in a sex-specific manner.

A neuropeptide regulates cell non-autonomous protein homeostasis dlvr.it/TRrsWf

Glia-to-Axon Transfer of Ribosomes and miRNAs: A Novel Paradigm in Neural Repair "Schwann cell-derived exosomes thus represent both a novel mode of glia–neuron communication and a promising avenue for next-generation therapies for nerve regeneration." onlinelibrary.wiley.com/doi/10.1111/jn…