Translating Aging retweetledi
We're pleased to share additional positive interim Phase 1 data for BGE-102, our potent, orally available, brain-penetrant NLRP3 inhibitor — showing potential best-in-class hsCRP reduction in patients with elevated cardiovascular risk.
Read the release:
ir.bioagelabs.com/news-releases/…
Key findings from our first MAD cohort in obese participants with elevated hsCRP:
• Rapid and profound reduction in hsCRP, a widely used marker of inflammatory cardiovascular risk: 86% median reduction at Day 14
• 93% of participants achieved hsCRP levels < 2 mg/L, the clinical threshold for reduced cardiovascular risk
• Broad anti-inflammatory effects: Significant reductions in IL-6 and fibrinogen, key independent markers of cardiovascular risk
• Well tolerated: Favorable safety profile with no dose-limiting toxicities
Path forward: Full Phase 1 data, including additional multiple ascending dose (MAD) cohorts in participants with obesity and elevated hsCRP, anticipated 1H26
Phase 2a study on track to initiate 1H26, with readout anticipated by year-end
Aging biology in action: Chronic inflammation is now recognized as a major driver of cardiovascular disease—on par with cholesterol—yet it remains undertreated. NLRP3 is a key driver of age-related inflammation, and BioAge's discovery platform showed that reduced NLRP3 activity is associated with healthy longevity. With the potential to deliver injectable-like inflammation reduction in a convenient oral therapy, BGE-102 could address a significant unmet need in cardiovascular risk management and beyond.
We look forward to sharing full Phase 1 results in the first half of this year!
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