Bioanalysis Zone

Eliminate software juggling by consolidating acquisition, processing and reporting in one environment. The @SCIEXnews OS does it all! This #TechNote demonstrates how, through automated integration, customizable reports and batch processing capabilities >>> hubs.ly/Q04gMLGK0

In this expert opinion article, Dr Yuri Fesko and Dr Timothy Looney from @QuestDX discuss a new Flow Cytometry MRD Blood Test for multiple myeloma, which uses a simple blood draw instead of painful bone marrow biopsies. Read on to find out how they address technical challenges in traditional flow cytometry approaches, like false positives from anti-CD38 therapies, reflecting on patient preferences and how the blood test offers a non-invasive and simpler approach to testing for multiple myeloma: hubs.ly/Q04gN7kV0

Find out the core principles of modern quantitative bioanalysis essential for pharmacokinetic and drug development studies in the @SCIEXnews Technical Note! Read here >>> hubs.ly/Q04fMwzy0

@Roche has received the CE Mark for the Elecsys® pTau217 assay, a blood-based test for Alzheimer’s disease pathology. The test was developed in collaboration with @EliLillyandCo and is designed to measure phosphorylated Tau 217, an indicator of amyloid pathology, a condition at the center of Alzheimer’s. Read the full story >>> hubs.ly/Q04gzxxx0 #pTau217 #Alzheimer's #PatientCentric

Interested in expanding your knowledge of #biomarkers? On Bioanalysis Zone’s biomarker page, you’ll find the latest trends on multi-omics integration, AI-driven analysis, expert interviews, and novel research on autoimmune diseases, like in @Merck_lifesci's new scientific poster. Learn more about biomarkers today! >>> hubs.ly/Q04d-LHz0

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disease that affects nerve cells, or motor neurons, in the brain and spinal cord, leading to a loss of muscle control over time. Often referred to as Lou Gehrig’s disease after the famous baseball player who was diagnosed with it, ALS is the most common type of motor neuron disease. Despite decades of research, ALS is a devastating diagnosis, with an average survival time of 3-5 years after symptom onset. However, the landscape of ALS research has transformed dramatically in recent years, driven by advances in bioanalytical technologies and our understanding of disease mechanisms. To mark ALS Awareness Month, we’ve compiled a collection of resources highlighting the role of bioanalysis in ALS research, including articles from @BioanalysisJnl, Biomarkers in Medicine, and Expert Opinion on Drug Discovery. Download the eBook for free here: hubs.ly/Q04g6_Lr0

.@BioRad’s latest guide highlights how Droplet Digital™ PCR workflows enable absolute quantification, improved sensitivity and enhanced reproducibility compared to traditional PCR and qPCR methods. Check it out here >>> hubs.ly/Q04d-M3V0

Watch our latest webinar on demand to learn about the key bioanalytical challenges unique to ADC therapeutics. Catch up here >>> hubs.ly/Q047GyMv0

Do you want to explore methods to overcome the complexities of #biomarkers? Download our latest infographic, created in collaboration with @WatersCorp >>> hubs.ly/Q04cjb9M0

Scientists have created a wearable skin patch that measures vitamin levels in sweat in real time, offering the potential for personalized nutrition monitoring. If you're someone who's interested in tracking nutrition and dietary responses, this article is for you ➡️ hubs.ly/Q04g6Kb30

Have you read this Research Article? The paper presents a one-step SPE method that greatly reduces blank tissue requirements and sample preparation workload by enabling use of surrogate matrix calibration and full automation. As well as simplifying and reducing analytical time in bioanalysis of tissue biodistribution studies, the SPE method also adheres to the principles of 3R. Read more here: hubs.ly/Q04fY1JY0

Download this Application Note from @merckgroup to learn about enhancements made for the new ultrasensitive #immunoassay platform! Read here! >>> hubs.ly/Q04d-WRP0

In the Zone: biomarkers in drug development – why strategy matters Check out our infographic and 2-minute video to explore how a strong #biomarker strategy can help overcome complexity and accelerate development! Find the In the Zone, in partnership with @WatersCorp here >> hubs.ly/Q04cjx4h0

Since the first therapeutic ASO was approved in 1998, there have been >20 ASO and siRNA approvals. Growing numbers of these therapeutics are reaching preclinical and clinical development stages, increasing the bioanalytical demand to deliver PK and safety data. In a new publication from @NanoveryLtd, a nucleic acid nanorobot assay for ASO PK bioanalysis was assessed for performance and inter-laboratory agreement. Hear from authors Cheryl Arrowsmith and Alexander Jackson in our latest Author's Perspective >>> hubs.ly/Q04dwDtM0 #Oligonucleotide #Bioanalysis #Pharmacokinetics #RNATherapeutics

Want to learn more about understanding hybrid LC-MS/MS bioanalysis? On @KCASBio’s company profile on Bioanalysis Zone, you’ll find features on LC-MS/MS, biomarker analysis, the evolution of CROs and more. Read the full profile here >>> hubs.ly/Q049pK-40

Explore how Droplet Digital™ PCR #workflows can elevate your gene expression studies! Download the full guide to optimize your assays and improve experimental confidence >>> hubs.ly/Q04d-LbH0

Read @merckgroup’s scientific poster: ‘Transforming autoimmune research with ultrasensitive biomarker quantification’ to learn more about how using SMC® technology coupled with the new FemtoQuest™ system enables simultaneous dual-plex analysis of low-abundant cytokines. Check it out! >>> hubs.ly/Q04d-K4s0

Advanced Cell Models (ACMs) are transforming drug safety assessments by enhancing what’s possible with traditional 2D cell cultures and animal models, offering human-relevant insights through 3D structures like organ-on-a-chip systems. In this interview, we sit down with Jurre Kamphorst, Director of Multiomics in the department of Clinical Pharmacology & Safety Sciences at @AstraZeneca, to discuss how ACMs, multiomics and AI are advancing and accelerating human safety prediction, including: - The role of ACMs in drug safety - Multiomics and AI in ACM selection - Criteria for replacing animal models - Regulatory alignment and challenges - Advice for overcoming regulatory acceptance challenges - Biomarker translation - Key skills for scientists moving forward Read the full interview here: bit.ly/42bO3Nh

A well-designed #biomarker strategy is essential for clinical success, helping to overcome complexity, accelerate development and drive real impact in the clinic. Learn more in our 2-minute video, in partnership with @WatersCorp: ‘Biomarkers in drug development – why strategy matters’ >>> hubs.ly/Q04cj2Z10

The latest pharma M&A deals include @SunPharma_Live's acquisition of @OrganonLLC: bit.ly/4umWX6E "This transaction represents a significant opportunity for Sun Pharma to build on its vision of Reaching People and Touching Lives. Organon’s portfolio, capabilities and global reach are highly complementary to our own, and we believe that bringing the two organizations together can create a stronger and more diversified platform. We have deep respect for Organon’s mission and look forward to building on its legacy while driving sustainable long‑term growth," commented Dilip Shanghvi, Executive Chairman of Sun Pharma.