Michael Barton

It's time we adopted more recent algorithms for FASTQ compression bioinformaticszen.com/post/use-zstd-…

Biden should pick Liz Cheney as his new VP candidate, that way everyone gets to shit their pants hashtag unity or whatever

@KillenTerri @amuse Plus a 10 min commute, close with his Mum, company throws picnics …? He’s also wearing a wedding ring

@amuse He has a good job. 3 meals a day. Nice house. Dog. Why sad?

This is literally the saddest thing I’ve seen in a very long time…

@CydeWeys @mornings0da This is why he would win. As long as he can memorize the games

@mornings0da Plus it's not cheating to consult Stockfish in between games!

This started a civil war in my chess chat between the cynics and the believers

@Andrea_chi77 I think you can just use homebrew now these days

@bioinformatics Hi, Michael, I'm trying to do this as well but I cannot make it happen. Would you mind to guide me through? i'm a beginner of using bioinformatic tools (not R) in Mac, and I found that its much easier when using minimap2 in HPC. I will be appreciated if you can help. Thanks!

Installing minimap2 on an m1 mac. The new apple silicon is aarch64 architecture and supports the neon instruction set. Took me longer than it should to put it together, given that it's in the README. make aarch64=1 arm_neon=1

@strnr @gringene_bio If you had just done the first one I almost would have believed it!

Checking out the release notes for bcftools 2.0 👀 bit.ly/bcftools20

@squarecog Along the same lines I think: web.mit.edu/nelsonr/www/Re…

A decade ago, a guy told me "this is obviously the right thing to do but it doesn't move my OKRs so I won't". Respect the honesty, I guess, but still mad about it.

@piersmorgan @StephenAtHome

The way certain American talk show hosts like @StephenAtHome mocked the Princess of Wales over her marriage in recent weeks now looks especially distasteful.

@goldimocks @Slither2006 @Negrosis2049 were they ok in the end?

@Slither2006 @Negrosis2049 It’s this scene 😭

Great news Oakland soccer fans! @oaklandrootssc & @oaklandsoulsc will play their 2025/26 season at the Oakland Coliseum. The Roots and Soul radiate Oakland pride in the community and every time they step on the pitch. They are a model franchise and the Town’s global ambassadors to the soccer world.

@altrickter Did they hear from you?

Upping the nutrition per sq ft in the garden this year

@harryglaser @hamiltonulmer Loved periscope back in the day! Really liked the interface. Even managed to get one of those SELECT coffee mugs, don’t know where it is now!

@simonw Nice! I do almost the same thing but in bash with the command ‘today’ that opens vim

Wrote up a TIL about my new private daily planner tool, which uses a Frankenstein combination of GitHub Actions, GitHub Issues and GitHub Pages to let me create a new issue every day to track my goals by hitting Command+N (new browser window) in Firefox til.simonwillison.net/github-actions…

@kirk3gaard @nanopore What’s the verdict on getting a great sourdough loaf?

Students at our department has been using @nanopore to characterize the community in homemade sourdough (and other DIY fermentation products).

@andyreed Dewalt aspiring to get a festool domino

when guys become dads they’re sorted into one of these four houses like in harry potter

@ryanstephens @hubermanlab I heard about this technique in the “learning how to learn course”

@hubermanlab When I WFH, I will sometimes lay on the couch, dangle my arm off with my keys in my hand and a metal bowl beneath. When the keys hit the bowl, the sleep is too deep, and I wake up and get back to work—usually 15-20 minutes tops, but huge mental boost.

When I was a pre-tenured professor, I hosted a prominent neuroscientist who was/is a member of the National Academy and Howard Hughes Investigator. He requested I include a 30 minute nap time in his schedule, because he understood that he gave the best talks only if he had a nap. Does anyone else out there insist on an afternoon nap at work? Does your workplace allow it? The data on napping support the idea that naps are net positive for productivity. Note: Don’t nap for longer than 20-45min, or if your nap interferes with your nighttime sleep.

Newsom: You mean the last two years, more Floridians going to California than Californians going to Florida? That is going to be fun to fact check.

@nopranablem Forwarded it to my therapist too haha Will listen to the Tim Ferris episode

@bioinformatics Check this out! Made this first episode beginner friendly 😀 x.com/nopranablem/st…

Got any questions about "somatic parts work" or IFS or anything else in this vein? Aiming to adapt this convo into some written work at some point

@HeidiArjes @ZHallberg Potentially test with a different reporter gene with a more observable signal?

@ZHallberg Intriguing - only with kan or with any abx marker mCh is also pretty weak if at single copy in Ec, may take a while to see visible redness, but might be detectible under scope/on typhoon in your original colonies.

@nopranablem the real reason we do all this work