Carl Gunnar Fossdal

@BiluHuang I do not disagree with the aging part Bilu. I was just pointing out the minor error in your post Bilu that you wrote that "This is because Caenorhabditis elegans lacks methylated DNA.".

No matter how DNA is modified, such modifications cannot be the cause of aging. This is because epigenetics is unstable and constantly maintains a dynamic balance between methylation and demethylation; therefore, it cannot form a chronological marker, nor can it serve as a clock that drives aging.

I have always believed that epigenetic clocks can only measure the degree of aging, rather than acting as the driving clocks of aging. This is because Caenorhabditis elegans lacks methylated DNA. The aging process of Arabidopsis thaliana, similar to that in mammals, follows a gradual decline in DNA methylation levels with advancing age. However, mutations in the TCX5/6 genes keep DNA methylation levels constant throughout the entire lifespan, yet the aging rate remains comparable to that of the wild type. During the aging of most somatic cells, DNA exhibits global hypomethylation, whereas the aging of hematopoietic stem cells is characterized by global hypermethylation. Deletion of the GADD45B gene also leads to elevated DNA methylation levels in young hematopoietic stem cells, producing epigenetic signatures similar to those of aged hematopoietic stem cells. Nevertheless, such methylation alterations do not trigger functional decline in hematopoietic stem cells; their self-renewal and differentiation capacities remain intact. These three lines of evidence clearly indicate that both the epigenetic theory of aging and the ITOA model are likely incorrect. The loss of epigenetic information is far more likely to be a consequence of aging rather than a driving cause. Partial reprogramming may be incapable of reversing cellular aging. Huang, Bilu, The Information Theory of Aging Is Not Reliable (June 21, 2025). Available at SSRN: ssrn.com/abstract=53156…

@jonathanbfine So true. Even hearsay has more rigor.

so many tweets lack intellectual rigor and that concerns me greatly

This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself cell.com/cell/fulltext/…

Remembering Leonard on what would have been his 95th Birthday 🎂

Today we celebrate the 112th birthday of Norman Borlaug. The man who fed the world. Borlaug developed high-yield, disease-resistant wheat that sparked the Green Revolution, saving over a billion lives from hunger. Happy Birthday, Norman Borlaug - hero of humanity.

@RandalHendrick9 Beauty

Look at my assassin kitty.

Chemical composition of a potato.

@jonathanbfine She really is an optimist

Wife: You should appreciate me because your life would be really sad and boring without me.

@RandalHendrick9 🥳

Ever notice how we erect obstacles to stand in the way of our desires? You don’t have to learn to be a hacker and become buddies with some inbred and addled prince. Just restore the Holy Roman Empire yourself.

@jonathanbfine @RandalHendrick9 Fine way to managing ego

@RandalHendrick9 If he doesn’t use me as his best friend I’m going to tell everyone his middle name, which I swore I’d never do.

I need to track down my childhood best friend whose name I use for the security question to reset my passwords to see if he enters my name to reset his passwords.

@jonathanbfine BFF

@neuralamp4ever 💯💯These two pieces of evidence clearly demonstrate that the epigenetic theory of aging is incorrect, and partial reprogramming will fail to reverse aging.

"Before we name, we touch. We propose that the roots of language lie not in abstract, amodal symbols but in early bodily experience." Our Opinion paper is out in TICS. Congrats Luca Sergey Rinaldi !! sciencedirect.com/science/articl…

@jonathanbfine Imagine someone hacked Reza Pahlavi's account instead?

If I had hacked Eduard Habsburg’s account, I would have already proclaimed the restoration of the Holy Roman Empire

I made this in an act of devastating rebellion against my Shaker grandfather. The asymmetry was a heavy slap in the face, but it was my unsurpassed craftsmanship that destroyed him.* *Table by Judy Kensley Mckie

@jonathanbfine I know. Finite is so rare these days.

sometimes behind the ironic facade it’s just infinite layers of sarcasm

@jonathanbfine Just perfekt

organizing my books would be a good spring break project but i think the chaos sends the right message to students

@jonathanbfine Fair enough

i’m primarily on twitter to get mad about things i don’t actually understand