Sabitlenmiş Tweet
BiotechObserver
85.3K posts
BiotechObserver
@BiotechObserver
An anonymous watcher. Likes are bookmarks, not endorsements or agreement.
United States Katılım Haziran 2018
255 Takip Edilen3.1K Takipçiler
Hmmmm
Avi Roy@agingroy
For a decade, the anti-aging bet was to lower NLRP3, a protein that switches on inflammation and helps drive age-related disease. A new paper says lowering it partway made mice age faster. The logic was sound. Chronic inflammation rises with age and contributes to heart disease, Alzheimer's, diabetes, and frailty, and NLRP3 is a major source. Removing it entirely in mice makes them age more slowly. That result, from 2013, kicked off a race to drug NLRP3. But a drug doesn't delete NLRP3. It only lowers it. So @CorderoMarioD's team made mice with one working copy instead of two, which is closer to what a drug does. Those mice aged faster: shorter lives, more frailty, worse metabolism, and, in females, earlier ovarian failure. The mice compensated. Lowering NLRP3 caused a second inflammasome, NLRP1, to rise and form a hybrid complex that produced more inflammation, not less. Cutting both restored them. Those blockers are already in clinical trials in people. Roche, NodThera, Ventyx, and Novartis all have NLRP3 inhibitors in human trials for conditions including Parkinson's, obesity, and heart disease, and each one lowers the protein rather than deleting it, the exact move that backfired in these mice. If that carries over, a partial blocker could worsen the inflammation it targets unless it also hits NLRP1. Still, it's mice, it's genetics not a drug, and human NLRP1 biology differs. A flag, not a verdict. Thursday, 16th July, @LauraMinquini and I will cover it with the author @CorderoMarioD on @athenabiorg's Menopause and Fertility show. The same inflammation that ages the body also ages the ovary.
QST
@joelpollak We're big mad so we have the right to kill your country's soldiers!
Entitlement off the charts. Par for the course of Palestinianism.
Killing our soldiers is an act of war, and we should stop responding with kidgloves to acts of war.
English
Scahill is wrong: soldiers weren’t the primary target of Hamas (he obscures civilian horrors). And even so, there is no “right” to attack the IDF. In theory an attack could be legal under a just war doctrine but then so would the response, which he rejects. Just hatred, at core.
Open Source Intel@Osint613
Ro Khanna isn’t pro resistance enough for Drop Site News. Can’t make this up.
English
@christian777788 @ariel_haivri You Catholic and Xtian ph@ggo+$ abused, murdered, tortured Jews for centuries claiming that "God" was behind it and responsible for YOUR behavior and choices.
And then the founding of the State of Israel & conquest of Arabs refuted your faith after 2000 years of lies & fakery.
English
God walks with the Jews. It’s why we’ve survived for this long.
We will outlive you and see our Temple rebuilt.
English
@Soul__Burn @ariel_haivri The holocaust bolstered the Catholic faith which proclaimed the "downtrodden Jew" as proof of their replacement theology. Hated & abused by God as a living testament to whatever catholic jesus bullshit.
But then the formation of the State of Israel negated their faith! Womp womp
English
@ariel_haivri So what did he do when you got holocausted, just stood there and ate popcorn? Lol
English
@LDSGroyp @ariel_haivri You retards said the same thing about returning to Israel and forming a Jewish state there. Derp!
English
@ariel_haivri If you even attempt to rebuild your temple that will mean the end of the Jewish race, not only will you unite the nations of the world against you but you will incur the wrath of God like you’ve never seen in your history
English
@ariel_haivri x.com/BiotechObserve… Jews hate to be reminded of the Catholic theology that was physically proven false after 2000 years of Catholics using it for hate-mongering & abuse of Jews in the service of a false, heretical idol-worshiping faith! God's promises kept.
Totally hate that
BiotechObserver@BiotechObserver
@AmYisraelChai_X He identifies Xtianity with the Romans? He is proud of murdering people and looting the Temple? "They hate to be reminded of that" We hate to be reminded that the entire false premise Catholic theology was built on (replacement theology) was disproven 2,000 years later? Lol ok
English
@mehdirhasan If a Muslim terrorist loses an election, "Muh AIPAC!"
I mean, if that were true then kudos to AIPAC for helping save america.
English
Sheesh those AIPAC dollars really working.
InteractivePolls@IAPolls2022
Michigan Senate Democratic Primary 🟦 Haley Stevens: 48% 🟦 Abdul El-Sayed: 41% ⬜️ Not sure: 10% —— Fav-unfav El-Sayed: 52-15 (+37) Stevens: 50-24 (+26( —— • Detroit News/The Glengariff Group • July 8-11 | 500 LV | ±4.4% detroitnews.com/story/news/pol…
English
@lcbnuoH ok but people do it. even if not typically palbo, the cdk4/6
English
@BiotechObserver "Re-use in 2L is among the usual practice" NCCN is clearly against this practice.
English
@lcbnuoH What do you mean, "nope?"
The BRAF-MEK combo was not approved.
This triplet was approved.
I explained how the situations were different and should not have been equated by that guy who got it wrong.
Now, what did I say that isn't true?
English
@BiotechObserver Nope. Even celc added references to the protocol that Palbo has no add on benefits on top of fulvestrant.
It's a tricky case bc NCCN explicitly suggested 2L Palbo if it's not used before.
English
Let's learn from this & point out the differences. Encorafenib and Binimetinib were both experimental drugs PFE was trying to get 1st approvals for in CRC. Palbo=approved BC drug, re-use in 2L already among routine practice. OS diff ~2m vs. 0.6. $CELC x.com/jq1234t/status…
English
@LDSGroyp @AdinHaykin1 Show us where the goats raped you
English
@AdinHaykin1 None of the things you claimed happened are shown in this video although it would be awesome if it did, the shepherd and his goats need to fuck off
English
> Violently attacks a shepherd who does nothing to them
> Abuses goats
> Claims it's all to protect a few aluminium huts in the middle of nowhere from "ethnic cleansing"
And then you cry victim when they block your car.
Andrey X@the_andrey_x
Settler harassment of Palestinians in Taybeh, West Bank 🇵🇸
English
@AdinHaykin1 You guys are losing your touch man I remember you used to bulldoze over these fucking retards
English
@the_andrey_x "He raped me with his goats and his sitting in the dirt!!"
English
@nick_matau Come on man, it was a stunt, and the people he was with in the car are not good-faith actors. Not in the slightest.
English
This is by far the most fair analysis of the situation that even offers to join Ro Khanna in calls to prosecute, if he provides the evidence he promised existed.
People saying "it was a recently opened closed zone" are acting in bad faith. You can hear in the video the guy say "this is a closed zone" - at best you have a misunderstanding (which is fair to assume, because JPost did A LOT of digging to figure out the status themselves). Being accidentally right and pro palis weaponizing that is insane.
If you have a take other than this one by @havivrettiggur, you are being disingenuous. Either the congressman produce the evidence, or admit this was a big nothing burger with a sprinkle of misunderstanding.
Haviv Rettig Gur@havivrettiggur
Alas, Mr. Congressman, I'm not lying. And I started this line of questioning assuming you were telling the truth. I've written long essays on extremist Israeli violence in the West Bank. I know it happens. I was ready, at first glance, to believe it happened here. But it didn't. This wasn't Israeli violence. This was agitprop for your American audiences. I said explicitly that I'm not familiar with the details of that area. It took a lot of effort for JPost to find out what it found out -- which was that it was a closed military zone only recently opened. But if you'd coordinated your visit with Israeli authorities, this would have been sorted out from the start. Those soldiers weren't angry or aggressive, they seemed mostly just confused about the status of the area and how to handle your visit. Because, you know, there was no coordination. JPost suggests all that in the article you yourself shared. And what of the violence? Your group had cameras -- a professional photographer and at least one bodycam -- yet you've produced no evidence that I've seen of the violence you claim to have experienced. Remember that you claimed the violence was sufficient to demand that Netanyahu order the prosecution of those soldiers. I've seen that sort of violence before; if you produce that footage, I'll join your demand for prosecution. That's not rhetoric. I really will, wholeheartedly. But if you don't, I think it's safe to assume you blew up a small inconvenience caused by your own refusal to talk to Israelis. In a similar vein, you used the word "detained" as if you were unlawfully held against your will -- and hide behind its second meaning, that you were a bit delayed in driving forward into the area. The first is on the spectrum of kidnapping crimes, the second is the sort of problem you'd encounter at the entrance to a federal building as you search your pockets for an ID. Which was it? Anyway, you were angling for some domestic political brownie points, and congratulations, you got 'em.
English
@havivrettiggur Hey cuck, no one has the "right" to kill our soldiers w/o consequence either. We don't owe Fakestinians anything & they are not entitled to murder over some nebulous idea.
Why do you play this one-sided game? Ppl u try to convince do not accept IDF killing terrorists, ever.
English
Gotta give it to him, Ro Khanna does remarkably well here.
If what he explains here about the need for a fundamental rethink of Palestinian strategy is his genuine belief, he may yet be part of the solution one day.
Jeremy Scahill is trying to drag Khanna into accepting that Hamas has a right to kill Israeli soldiers. Not because there's a basic legitimacy to war under international law, and Palestinians are allowed to declare and wage war as much as anyone else. But because Scahill's immediate next move will be to deny that Hamas ever targeted civilians, and so October 7 as a whole was just one big happy totally-legal and unquestionably moral military event you shouldn't question. And to call it a brutal massacre with terroristic intent is racist.
It's kinda like how he pretends that Palestinians ever seriously tried nonviolence as a coherent strategy -- something more than occasionally claiming to try it tactically for a moment at a small scale purely for propagandistic purposes.
Scahill doesn't actually know what King meant by "nonviolence," or he'd have known that the March of Return wasn't it.
And throughout, Khanna keeps his cool. He seems to know Scahill's next moves and refuses to play the game.
Incidentally, if Palestinian factions had only ever attacked Israeli soldiers and only ever demanded independence -- and not, you know, systematically targeted civilians for many years and demanded the extermination of Israel -- history might have gone very differently.
Scahill knows that and doesn't care. He's the special sort of ideologue who thrills at righteous bloodletting. He denies Hamas brutality because he wants to see more of it. He's not trying to defend the laws of war, he's trying to launder Hamas.
Drop Site@DropSiteNews
💢 Jeremy Scahill asks Rep. Ro Khanna: “Do Palestinians have a right to kill Israeli soldiers, Congressman?” “On October 7, did Palestinians have a right to attack Israeli military bases in the Gaza envelope? Yes or no?” 🎥 Watch Khanna’s response in the attached clip. Longer discussion in the post below ⬇️
English
@jshakov @havivrettiggur @JewishSpaceLazr @TheModerateCase @RichardIngleby2 Don't you see them working with the IDF in the video?
There's your proof, dummy.
But we don't owe you proof.
We are not going to sacrifice our lives for the sake of your feelings or Arabs' perceived microaggressions.
English
I want to hear an official idf/police/government statement that this was a civilian security team authorized to block roads and stop vehicles in a non-military zone or in a closed military zone (that they were not aware of its recent status change).
There has been none such statement and the rude man on the video doesn’t look like a professionally trained security, more like a thug.
English
Ro Khanna’s detainment was illegal.
Settlers have no right to stop vehicles, and the area wasn’t even a restricted zone. It used to be, but currently isn’t.
AND… it was only restricted previously because of Israeli settler violence post 10/7.
I’m seeing lots of false narratives about the situation, and as much as I dislike Ro Khanna, the facts are the facts.
English
@jshakov @havivrettiggur @JewishSpaceLazr @TheModerateCase @RichardIngleby2 Are you demented? You seem to have ignored two thirds of my comment.
Civilian security teams are a very important component of living in dangerous areas where Arab terrorists routinely attempt and carry out brutal massacres.
Don't like it? Too f'n bad!
English
Under what authority can civilians block roads? If they have official legal authority, I’d like to see the details.
And if they do have such authority, why are they behaving unprofessionally?
Also, why hasn’t Bibi’s government issued an official statement explaining the legal basis for blocking the road?
English
@real_IHN_isback @Natsecjeff And not the first time either.
Kuwait must have a strong lobby or something
English
