Blainey Lab

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Blainey Lab

Blainey Lab

@BlaineyLab

Official Twitter account of the Blainey Lab @broadinstitute

Cambridge, MA Katılım Aralık 2020
64 Takip Edilen1.1K Takipçiler
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Broad Institute
Broad Institute@broadinstitute·
Using an image-based screening method, Broad and Boston University researchers found potential new drug targets for reducing Ebola infection severity, uncovering human genes that, when silenced, impaired Ebola’s ability to replicate. broad.io/Ebola-News-0724
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Blainey Lab retweetledi
Russell Walton
Russell Walton@russelltwalton·
We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…
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Julie Chen
Julie Chen@jc_JulieChen·
Excited to share my primary PhD work! Vibrio isolates can produce peptide deformylase inhibitors that induce prophages in their lysogenic competitors. Not only is it SOS-independent, but also serves as the first example linking translational stress with prophage induction 👀 1/
bioRxiv Microbiology@biorxiv_micrbio

Bacterial peptide deformylase inhibitors induce prophages in competitors biorxiv.org/content/10.110… #biorxiv_micrbio

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Blainey Lab
Blainey Lab@BlaineyLab·
Recently published in @PNASNews our high-throughput screen of 1.3M+ antibiotic combos identified P2-56 as a rifampin potentiator against A. baumannii & K. pneumoniae. pnas.org/doi/10.1073/pn…
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William Allen
William Allen@weallen1·
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…
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Blainey Lab
Blainey Lab@BlaineyLab·
New @biorxivpreprint! w/ our high-throughput screening approach, screened 1.3M+ antibiotic combos against high priority, drug-resistant bacterial pathogens, identified small molecule P2-56 as a potentiator of rifampin against A. baumannii and K. pneumoniae biorxiv.org/content/10.110…
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Blainey Lab
Blainey Lab@BlaineyLab·
We are excited to share our new @biorxivpreprint about CROPseq-multi with the community, many thanks to our @russelltwalton for this Tweetorial about his work with @Yue_Qin_SysBio! @broadinstitute @MITdeptofBE @Schmidt_Center
Russell Walton@russelltwalton

Our new preprint describes “CROPseq-multi”: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens doi.org/10.1101/2024.0… Reagents on Addgene: addgene.org/browse/article…

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Meilin Zhu
Meilin Zhu@mzhu_ology·
Excited to share our preprint on metabolic differences in the vaginal #microbiome. We find key differences in fatty acid metabolism among #Lactobacillus species & leverage those findings to identify a potential new therapy for bacterial vaginosis (BV) & #WomensHealth 🧵 (1/n)
bioRxiv@biorxivpreprint

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment biorxiv.org/cgi/content/sh… #bioRxiv

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Keşfet

@NatureMicrobiol @beccajcarlson @neidl @broadinstitute @CellReports @BiedererLab @PNASNews @BostonChildrens