Science in Boston

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A new tool has just vastly broadened the scale at which researchers can study viral proteins, helping to speed basic discoveries in #virology. The tool, called a viral ORFeome, was developed by Dr. Stephen Elledge's lab at @harvardmed: bit.ly/4wJKRWd

Quilee Simeon is using AI to simulate the nervous system of small model organisms as part of his doctoral research at @mcgovernmit. The goal is to use those simulations as a window into understanding how an animal’s #NervousSystem executes tasks: bit.ly/3T7vKrh

Researchers from the lab of @MCB_Harvard's Dr. Sharad Ramanathan have developed a rapid, inexpensive method for introducing the same #CRISPR gene perturbation into nearly every cell of a developing human #organoid. 📰 Read all about it! bit.ly/4piQqIZ

A consortium of 12 organizations, led by the @broadinstitute, has been selected to receive funding from @ARPA_H under its THRIVE program. Dr. Daria Fedyukina leads the THRIVE program. Learn more about their work: bit.ly/4fcJNTB

Dr. Fan Wang and her team at @mcgovernmit has discovered how neurons in a mouse’s brainstem use signals from the animal’s touch-sensitive whiskers to estimate an object’s distance from the face. 🐭 bit.ly/3TznZKL

Each year, the @wyssinstitute's Validation Project program identifies technologies that are ready to move beyond the discovery and into the validation phase. Learn more about the 16 teams and their projects: bit.ly/3Rwy5eO #BrainHealth #WomensHealth #InfectiousDisease

Consider this your sign to subscribe. 👀 Sign up for the Science in Boston newsletter for a chance to win: 🎟️ 2 tickets to MIT Museum's After Dark series 🍹 Dinner on us Enter here: bit.ly/3R19X3o

Boston, we're coming to you! Join us at MIT for an interactive workshop on how to explore and use cell type taxonomy data and tools from the Brain Knowledge Platform. 🎟️ Registration is free 🔗 connect.alleninstitute.org/e/exploring-ce…

MCO PhD Candidate Arshia Mostoufi Receives Prestigious Canadian Doctoral Fellowship mcb.harvard.edu/department/new… @ArshiaMostoufi @CIHR_IRSC @HarvardGSAS @Harvard @HSCRB

Melanie Barbini at @UMassChan is the recent recipient of a three-year predoctoral fellowship award from NIAID. She will investigate how a specific protein expressed by ependymal cells contributes to inflammation within the #CNS. 🥳 Congratulations! bit.ly/4gXd33m

A new study from @DanaFarber reports the first potent and selective compound to target IRF4 and validates degradation of IRF4 as a potential approach to the treatment of #MultipleMyeloma. 🔎 See the abstract from Drs. @JunQiLab and @IrenemGhobrial: go.nature.com/4wq8rY0

Research by Dr. Katherine Fitzgerald and Wei Zhan at @UMassChan shows potential for increasing vaccine efficacy. 💉 The findings have the potential to transform otherwise weak vaccine adjuvants into powerful innate #ImmuneSystem stimulators: bit.ly/4b9B2bO

New in @NEJM: Phase 3 LITESPARK-022 showed belzutifan + pembrolizumab significantly improved disease-free survival in high-risk kidney cancer after surgery. The FDA recently approved the combo in this patient population. Study lead @DrChoueiri of @DanaFarber explains:

A new statistical framework could speed up the search for rare mutations that cause common diseases like #Parkinson's, helping researchers zero in on therapeutic targets. Learn about the framework, NERINE, from the Sunyaev & Khurana labs at @Harvard: bit.ly/4eQQoEF

Metastatic melanoma is the deadliest form of #SkinCancer. @DanaFarber’s Dr. Megan Insco and colleagues examined how melanoma cells misuse RNA. 🥼 Abstract in @CellReports: bit.ly/4xZcfkD 🗞️ Press release: bit.ly/4gg94Pe

📝 A team of @MCB_Harvard scientists has published findings that fundamentally challenge how we think about #BrainDevelopment. The study reveals that neural activity actually dictates how neurons wire themselves together, rather than the reverse: bit.ly/4eEd7DD

🤩 Raphael Reyes in the Batista Lab at the @ragoninstitute is recipient of the 2026 Warren Alpert Distinguished Scholar Fellowship in Immunotherapy. His research investigates how the immune system helps maintain a healthy vaginal microbiome: bit.ly/4wiH7ed

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Dr. Sarah Sandler at the @wyssinstitute is working on NanoDEX, a platform that helps discover drugs for targets that the pharmaceutical industry has historically struggled to screen. Learn more about the nanopore-based technology: bit.ly/4f0ihtM

An estimated one million Americans are afflicted with post-treatment #LymeDisease syndrome. Newly funded research at @tufts seeks to determine whether the condition is triggered by a persistent autoimmune response and who is most susceptible: bit.ly/3OWqg0F