Bo Peng

We are proud to share our latest study published in Science. After achieving efficient and clinical feasible microglia replacement for the first time in 2020 (PMID: 32783928), we applied this strategy to treat a severe and fatal neurological disease, ALSP, and observed remarkable therapeutic effects—not only in the mouse model, but also in clinical trials involving 8 individuals with ALSP and up to 24 months of follow-up. This marks the first-in-human clinical application of microglia replacement therapy and suggesting its therapeutic effects in more neurological diseases. Check out the study at science.org/doi/10.1126/sc…

@TheColonnaLab @ScienceMagazine @khainotkaiorky Amazing study! Big congrats!

Our study is out in @ScienceMagazine! It shows that CAR-expressing astrocytes (CAR-A) can recognize and clear amyloid aggregates, reducing pathology and restoring microglial homeostasis in AD models. Led by Yun Chen, Alex Liu and @khainotkaiorky! doi.org/10.1126/scienc…

I’m happy to be formally selected as the category winner in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @TakedaPharma @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁. nature.com/immersive/inno…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy (PMID: 40638739). We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

Research Spotlight 💡 Wu et al. (*Science*, 2025) report the first human microglia replacement therapy. Bone marrow transplantation replaced defective #microglia in ALSP patients, halting disease progression and improving neurological function. science.org/doi/10.1126/sc…

@jonykipnis @DuSiling @TheColonnaLab Congrats!!!

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins. ⁦@DuSiling⁩ ⁦@TheColonnaLab⁩ | Nature Neuroscience nature.com/articles/s4159…

I’m happy to be selected as a shortlisted finalist in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @Takeda @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁. This award celebrates groundbreaking research by early career scientists who are advancing the frontiers of scientific discovery in the areas of gastrointestinal and inflammatory diseases, neuroscience, and oncology. Takeda will award three category winners – one from each area of focus – in February, and one grand prize winner in April. I’m honored to receive this recognition and I’m excited to participate in Nature’s career development programs, while building meaningful connections with my peer awardees. nature.com/immersive/inno… linkedin.com/company/takeda… linkedin.com/company/nature…

@ShellyFan AI may replace us some day in the future. Before that, we have already been able to replace our microglia 😀

My intro book to #AI is now out! Perfect for high school/uni students wanting to go into the field, and people who don't speak #machinelearning to get a taste of cutting-edge algorithms w/o the math. Available in 5 foreign language & bingable in a day 😍 amazon.com/Will-AI-Replac…

We are delighted to share our newly published Perspective review on microglia replacement in Cell Stem Cell @CellStemCell. This comprehensive article provides an in-depth overview of most key aspects of microglia replacement, including its concept, history, mechanistic principles, implementation strategies, relevant microgliopathies, applications, clinical trial, and future directions. We hope this review serves as a valuable resource for the community of microglia biology, neuroimmunology, and cell therapy. Find the full article here: cell.com/cell-stem-cell…

Latest Nature News of microglia replacement. Swapping old immune cells in the brain with fresh ones could treat disease nature.com/articles/d4158…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

Research Highlight: Microglia replacement halts rare brain disease progression nature.com/articles/s4158…

Replacing defective microglia with wild-type microglia using microglia replacement by bone marrow transplantation halts the progression of microgliopathy in mice and human science.org/doi/10.1126/sc… #NBThighlight

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

Microglia to the Rescue | Science | AAAS science.org/content/blog-p…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

In 8 CAMP patients, a bone marrow transplant halted progression of the disease for at least 2 years! Amazing work published in @ScienceMagazine science.org/doi/10.1126/sc…

Ecstatic to announce that I've teamed up with @DrSamuelBHume to write on his Substack breakingground.substack.com aimed at keeping you up to date on developments in medicine! My first article is live, on a potential treatment for an incurable brain disease breakingground.substack.com/p/advances-in-…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

脳の免疫細胞「ミクログリア」の遺伝子に異常があると、脳組織が破壊される致命的な病気ALSPになります。 研究者たちは骨髄移植という方法で、異常なミクログリアを正常なものに置き換えることを試みました。 するとマウスでも人間でも病気の進行が止まり、脳機能が改善しました。 これは「悪い細胞を良い細胞に取り替える」という画期的な治療法で、他の脳疾患にも応用できる可能性があります。

science 上海交通大学 CSF1R遺伝子変異による致命的脳疾患において、骨髄移植により正常ミクログリアに置換することで病気の進行を止めることができた。 science.org/doi/10.1126/sc…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!