Brayton Williams ⏻

Crypto created digital scarcity. AI creates digital abundance. Crypto is money as code. AI creates tools to find vulnerabilities in code. Short term crypto will be bumpy, but the long term thesis feels stronger than ever.

this is our most dynamic summer yet @newlimit - 3X data efficiency for reprogramming AI from lineage generalization - >100X manufacturing scale for our lead therapeutic asset - +4 leads that restore function in old hepatocytes, +5 payloads in endothelium & lots more in our blog

Happy 250th! American Values Reflected in Hardware

@honam @BoostVC 🙏

@BraytonKey @BoostVC No surprise. Congrats!

500 VCs voted on which fund is the most helpful Deep Tech investor. @BoostVC got #1!

Full rankings: deep-tech.com

Amazing to be recognized by our peers. We pride ourselves on being the most collaborative! Thank you all.

They polled hundreds of Deep Tech VCs to determine the most helpful Deep Tech VC. Honored to see @BoostVC voted #1 among so many of our amazing peers! deep-tech.com

If you want to give humans superpowers, this is the team to join.

@ajhodls No adjustments. Raw SAFE #’s.

@AdamDraper @credistick 🪄🧙‍♂️

@BraytonKey @credistick How do you make text arrows

Our median Pre-Seed post money valuations (Based on ~25–40 investments each year.): 2022: $7m 2023: $5.5m 2024: $6.5m 2025: $5m 2026: $8m I've had a lot of people ask what we're seeing in 2026, so I figured I'd share our data.

@patmatthews Always think 20% of the fund is more opportunistic.

@BraytonKey This is good. How do you guys handle the “don’t miss a great company because the price is too high” sentiment? Ignore high prices? Invest out of a different bucket?

@Trace_Cohen $500k-$2m Sometimes we are only check. Sometimes we participate in a round. Sometimes we lead a round. Pretty flexible. Also many deals get done with us writing a check and then subsequent SAFEs close on progressively higher prices.

@andrewparker Definitely something we go back and forth on.

@BraytonKey yeah, the interesting piece to me is the flat $500k. I think it would be mighty tempting to increase check size to maintain initial own% in a hot market. But agree, 10% or 8% of a mega multi-billion rocketship is kinda the same thing, at your fund size especially.

@andrewparker As long as we are in a winner. And that winner is really big, I don't think it matters. Outcome size seems to be outpacing the entry price rise. But also, I would definitely love 20% more of our winners 😀

@BraytonKey do you think a 20% raise in Post over a couple years will lead to a 20% reduction in realized DPI 15 years later, does it not really matter?

@credistick Few noticeable trends in last 2 years: Bio ↑ Energy ↑ Crypto ↓ AI ↓

@BraytonKey Any shift in the type of companies you're tending to invest in? e.g. more robotics, bio, etc.

@davidfeiock Median check size: $500k each year

@BraytonKey avg check $?

@sethbannon Insanely epic! Just told a new LP yesterday you were a fund I would recommend 🚀

Ten years ago, almost everyone told us the same thing: back companies solving humanity's biggest problems, and you'll have to accept lower returns. Today we sent our LPs a note announcing that Fifty Years Fund I has reached 7.5x DPI.

Seeing more and more divergence between Twitter/X sentiment and customer sentiment. Sometimes that's because founders are optimizing for fundraising and not customers. And yes...it clearly works on us VCs 💸