Jon Brestoff

Curious about #mitochondria transfer? Check out our latest #MitoTransfer review with the @theHumanBorch in @Nature Feel free to post your thoughts, ideas, and questions below. Please RT to help grow this blossoming field. nature.com/articles/s4158…

@CaicedoLab Wow! Congrats Andres!

🚀 ¡Nivel desbloqueado! 🔬 Hace 10 años veía muy lejano poder alcanzar la categoría más alta de investigadores en Ecuador. Hoy, después de mucho trabajo en equipo, artículos, proyectos, retos, maestrías y doctorados acompañados, recibo este logro con enorme gratitud. Gracias, @EduSuperiorEc @SerBachillerEc 🙏✨ Mi gran gratitud a cada colega, amigo y colaborador que me dio la mano para seguir adelante y construir ciencia desde Ecuador con ambición, rigor y corazón. 💡🤝 Gracias a mis chicos, porque compartir este camino con ustedes ha sido una de las partes más valiosas de todo este proceso. Verlos crecer, cuestionar, investigar y soñar juntos nos recuerda que la ciencia se construye en comunidad. 🧬👩‍🔬👨‍🔬 Al final, cada paso, cada reto y cada aprendizaje construyen el camino, incluso más allá de cumplir una meta.🚀 Gracias, equipo. Gracias, @USFQ_Ecuador . Gracias a Dios por este gran logro. 🙏🔬🇪🇨✨ lnkd.in/etwAiaJK

Butyrate extends health and lifespan in mice with mitochondrial deficiency nature.com/articles/s4146…

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…

@v_moreno_juan @Samanthakrysa @Nature Great work! Congrats on your exciting and important paper!

So cool that @Samanthakrysa and @BrestoffLab wrote this News & Views article at @Nature about our work!! Thank you both so much for highlighting our study and for your thoughtful perspective. 😊 nature.com/articles/d4158…

Exciting new paper on #MitoCatch to target mitochondria transplants to cells of interest, rescuing neurons in #LHON Check out our News & Views in @Nature for a synopsis and big questions for the field: nature.com/articles/d4158… @washu_pathology @washumedicine @Samanthakrysa

@NatRevImmunol @rockygiwa

Metabolite and nutrient regulation of macrophages in obesity and metabolic disease dlvr.it/TS3BNj

ok actually insane paper published yesterday a research group in Korea built a gene switch you can control wirelessly using electromagnetic fields they exposed mice to 60 hz EMF (same frequency as your wall outlet) using a pair of large coils that generate a uniform magnetic field around the animal, for cyclic 3-day on / 4-day off pulses they showed this could: - activate OSK to do epigenetic reprogramming in progeroid and aged mice, extending lifespan and reversing aging markers across multiple tissues - conditionally switch on mutant amyloid genes only in aged mouse brains, letting them separate aging effects from amyloid effects to study AD biology in a way previous models couldn't no drugs, no impacts, just a magnetic field from outside the body

@v_moreno_juan @NicolasAvilaJA @Nature @IOB_ch Congrats! Exciting paper!

I am very happy to share that our paper is now published in @Nature 😊 Cell-type-targeted mitochondrial transplantation rescues cell degeneration. nature.com/articles/s4158… @IOB_ch (1/6)

Coming up in this research space, reviewers and peers made it very clear that any non-visual effects of light on biology were not to be discussed in the public forum. What an exciting development to see the effects of energetic patterns rooted within the electromagnetic spectrum featured in @Nature . Looking forward to the flood of exciting research programs and therapeutics to emerge in the next few years. The bittersweet reality is that the effects existed before this high-profile exposure. But better late than never!

@niroshajmurugan @TOEwithCurt I love this

A physics insight that changed how I see biology is that non-equilibrium systems coordinate communication through constraining energetic landscapes, not just stepwise, diffusion-based reactions. Many cellular decisions happen too quickly and synchronously for molecular cascades alone, suggesting biological information is not only chemical. Energetic modalities like light and electromagnetic fields influence organization and function across scales. This feels there's an overdue intergration of these first-principles in physiology.

What’s an idea (math, physics, or otherwise) that changed how you see everything?

I’m excited to be launching a new publication on Substack today: The Science and Experience of Energy! The last few years have invited me, like many of us, to clarify my place in the world. I’m a scientist who’s devoted his career to bridging mitochondrial science and psychobiology. But I want to do more than just publishing papers for other academics—it’s important, but not sufficient. I am moved to bridge science and experience not just in the lab, but in life as well. That’s why I’m writing the ENERGY book. And why starting this Substack makes sense now. It feels like a coming out of sort, from my academic shell: sharing some things that non-scientists may not know about, and sharing experiences that scientists typically don’t talk about. That bridging of science and experience, I feel, will propel us forward towards a deeper truth about who we are and how we can fulfill our potential. I’m excited to share this journey with you. In this publication, you’ll find three types of pieces: 1. The ENERGY SCIENCE pieces will share the latest advances in mitochondrial science. 2. The BEHIND THE PAPER category will describe how a specific study came to be, or the backstory of a discovery. 3. The LIVED EXPERIENCES will allow you to connect with other human beings willing to share their energetic experience of growth and transformation. Everything in this publication will always be free. I’ll put energy in each post. And as the publication grows, we’ll invite others to contribute their energy as well, including my wonderful wife @msahsorin. Please join us by subscribing. And if you feel so compelled, sharing with your community. martinpicard.substack.com

#throwback COMMENT | @CreweLab et al A brief guide to studying extracellular vesicle function in the context of metabolism nature.com/articles/s4225…

@GreletLab @NatMetabolism Thanks, Simon

@BrestoffLab @NatMetabolism Congratulations! This is well deserved for such an important review.

This was a fun surprise today! #1 cited review in @NatMetabolism in 2025.

Steven L Teitelbaum, MD, a legend @washumedicine, passed away. He was a rigorous physician-scientist, life altering mentor, fierce advocate, and family man. I feel lucky to have gotten to work so closely with him. Few have taught me as much as he did.

Proud to announce Dr Stella Varnum! Her defense today was flawless. She is the first PhD student to graduate from my lab, so it was extra bittersweet today. #proudPI @WUSTLImmuno

Very excited for tomorrow and for soon-to-be Dr. Stella Varnum!

@MitoPsychoBio @riegalski Thanks Martin!

@riegalski @BrestoffLab is amazing

It seems likely that mitochondria transfer and mitochondria-based therapies will be a significant part of medicine in the future.

Boosting mitochondria number and function to slow cellular aging washingtonpost.com/science/2025/1… pnas.org/doi/10.1073/pn…