Christian Burns

Our paper "Intravital Two-Photon Microscopy of the Native Thymus" demonstrating in vivo imaging of the native thymus for the first time is finally out. @JoelSpencerLab You can read it here: journals.plos.org/plosone/articl…

Our live tissue clearing paper is out in @naturemethods! We achieved optical clearing of mammalian brain tissues without compromising normal neuronal function. Big congrats to @Shigenori774 and our wonderful collaborators! 🎉 nature.com/articles/s4159… (1/10)

Cell誌に論文が掲載されました！ 組織透明化とライトシート顕微鏡を用いて、マウス全身の細胞を三次元・単一細胞解像度で可視化し、全身の全細胞アトラスを構築しました。上田先生(@hiroking1975)をはじめラボの皆様に深く感謝いたします。sciencedirect.com/science/articl…

Our latest preprint list is now up on FocalPlane. This list is focussed on new tools and techniques in imaging. Let us know if you have any recommendations for us to add to our list. focalplane.biologists.com/2026/02/20/mic…

In vivo aberration measurement and correction for ultrafast FACED two-photon fluorescence microscopy of the brain Jun Zhu et al. doi.org/10.64898/2026.…

A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain and multiple organs at cellular resolution. Adriano Aguzzi and Fritjof Helmchen teams. biorxiv.org/content/10.110… #DISCO #clearing #3Dimaging #lightsheet #HumanTissue #FFPE #Histology

Huge congratulations to our 2025 MMI Image Competition Winners! 1st Place: Dr Melinda Wang (Top Left) 2nd Place: Ashleigh Paschek (Top Right) 3rd Place: Crystal Li (Bottom Right) SciArt: Connor Leayr (Bottom Left) Details of winning & standout images upcoming. Stay tuned!

aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue blocks Anna Maria Reuss et al. doi.org/10.1101/2025.0…

A new study uncovers an anti-resonance effect in Wnt signalling, where pathway activity is suppressed at specific signal frequencies. Using optogenetics and modelling, the work shows how signal timing shapes cell fate decisions. 🔗 elifesciences.org/articles/10779…

Out now in @ScienceAdvances our new work @lab_costa @AndreaBassi78: MAcro Plant Projection Imaging (MAPPI): An open, scalable platform for whole-plant fluorescence real-time imaging | Science Advances science.org/doi/10.1126/sc…

A Clear Look: New approach to tissue clearing for light-sheet microscopy called ADAPT-3D preserves architecture for 3D imaging 📷 Daniel D. Lee & Kevin A. Telfer et al @washumedicine in @SciReports ➡️ bpod.org.uk/archive/2026/1… with @AntDLewis

📢Our latest #preprint list is now up on FocalPlane In this list, we focus on new tools and techniques in imaging 🔬. Let us know if you have any recommendations that we have missed. focalplane.biologists.com/2026/01/09/mic…

Head-mounted 2-photon miniscope voltage imaging! Weijian Yang's group at UC Davis sped up 2p scanning by multiplexing to achieve 400-Hz voltage imaging of ~20 neurons, using ASAP4e. These are the first freely moving single-cell voltage recordings as far as I know.

Felix Zhou's-Segment3D is out: nature.com/articles/s4159… It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation. It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.

A computer model comparing blood cell transport in healthy & cancerous tissue - includes physiologically significant parameters hard to measure in life 📹 Abhay Mohan & Prosenjit Bagchi, @RutgersU in @BiophysJ ➡️ bod.org.uk/archive/2025/1…

"The Dance of the Coordinated Steppers" - the multi-dimensional Bresenham algorithm in action with non-linear acceleration. For more see my Patreon article: patreon.com/posts/cnc-su07… @OSMicroscopy @MicroscopySoc @BioImagingUK @RoyalMicroSoc #STEM @FreeCADNews

🔬📱 Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope. Our latest work published in Nature Communications. nature.com/articles/s4146…

@KusumbeLab These are vessels in the dura mater!

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues present OSCAR, a framework to quantify 3D stacks with high cellular density. journals.biologists.com/jcs/article/13…

3D-printed simulated tissue engineered to have the mechanical properties of living flesh & embedded fluid-filled capsules to mimic blood 📹 (sped up 2X orig) Adarsh Somayaji et al @UMNME in @ScienceAdvances ➡️ bpod.org.uk/archive/2025/9…

Scientists present an advanced new technique for live-imaging regenerating limbs, shown here on a sand flea. elifesciences.org/articles/10753…