Bursac Lab

Our newest paper "Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure" was just released in @ScienceAdvances! Check it out here: science.org/doi/full/10.11…

Inducing stable polyploidy in human iPSC-derived cardiomyocytes affects their transcriptome, cell cycling, and function. #AHAJournals #ResearchLetter @BursacLab ahajrnls.org/460913e

Our newest paper, "Effects of Pharmacological Polyploidization in Human iPSC‐Derived Cardiomyocytes", was just released in the Journal of the American Heart Association! @JAHA_AHA Check it out: ahajournals.org/doi/10.1161/JA…

Our new publication "BacNav Gene Therapy Improves Function of Infarcted Engineered Human Myocardium and NHPs" was released in Circulation Research! @CircRes Check out the article and press release below: ahajournals.org/doi/10.1161/CI… pratt.duke.edu/news/heart-gen…

For the first time, @DukeU researchers including Torie Broer generated in vitro robustly vascularized, highly functional engineered human skeletal muscle tissues, that mimicked in vivo satellite cell abundance and density. 🛰️ bit.ly/3MV4Dt4

⚗️Dr. Alastair Khodabukus and colleagues, describe the first 3D tissue-engineered hiPSC-derived #SkeletalMuscle model of LGMD2B. The model exhibits compromised contractile function, calcium handling, membrane repair 🩹 among other features. @BursacLab bit.ly/3XGxpUK

How is muscle replaced with fat in patients with limb girdle muscular dystrophy 2B? Our most recent work uses 3D engineered skeletal muscle to explore the molecular mechanisms at play in this untreatable disease. pratt.duke.edu/news/lab-muscl… @JainFoundation @DukeEngineering

Our newest publication "Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy" was just released in Advanced Science! @AdvSciNews Check it out here: onlinelibrary.wiley.com/doi/10.1002/ad…

Can we use cancer's tricks to help make a non-regenerative organ grow? Our newest paper explores how a common skin cancer mutation can encourage heart cells to multiply. pratt.duke.edu/news/skin-canc…

Our newest paper "Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium" was just released in @ScienceAdvances! Check it out here: science.org/doi/10.1126/sc…

Congratulations to the Bursac Lab members recognized at the @DukeEngineering BME Retreat! Marisa - TA excellence award Abbi - 1st place rapid-fire talk Torie - TA of the Year award Amber - NSF GRFP awardee

#PublicationFriday📚 #SCGE PI Dr. Nenad Bursac (@BursacLab) and his team observe satellite cells, cells responsible for #muscle repair, to address muscle degeneration human sciencedirect.com/science/articl… @dukebiochem

The Bursac Lab is hiring! Join our team as an Associate in Research focused on skeletal muscle biology and regeneration. bursaclab.pratt.duke.edu/positions

This one has been a labor of (mostly) love over the last 2.5 years or so, and I'm so happy to be able to share it now. Grateful to Dr. Glass,@Marc_Halushka, @APLandstrom, @joemaleszewski, Dr. Andersen, and @BursacLab 🫀 nature.com/articles/s4159…

We had amazing weather for Yifan's going away lunch today! We will miss you Yifan, but we know you will make us proud in your MD-PhD program!

'Exciting' news about our work to develop a voltage-gated sodium channel platform for cardiac gene therapy! youtube.com/watch?v=Vp-qAR…

Our most recent publication highlights our work optimizing the delivery route for cardiac regenerative therapeutics doi.org/10.3389/fcvm.2… @FrontCVMedicine

Just one piece of years of collaboration led by @BursacLab, Adam Williams, Dawn Bowles and many others and supported by Translating Duke Health (@DukeMedSchool). Exploring the optimal method to deliver therapeutics for cardiac regeneration. frontiersin.org/articles/10.33…

Pretty amazing work by my fellow grad student Tianyu Wu in the @BursacLab in collaboration with @APLandstrom and @perelli_robin to treat cardiac arrhythmia with engineered sodium channels. @DukeEngineering @DukeMedSchool #heartdisease #HeartMonth

Gene Therapy for Heart Disease genengnews.com/topics/genome-… via @GENbio