Burstein lab

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Burstein lab

Burstein lab

@BursteinLab

Having fun with microbial genomic and machine learning @TelAvivUni

Israel Katılım Eylül 2022
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Burstein lab
Burstein lab@BursteinLab·
Fellow microbial immunity, mobile elements, and plasmid enthusiasts: the paper of our wonderful @BruriaSamuel on anti-defense genes in plasmids is now published in @Nature!!! Check out her thread below for highlights of our new results. 1/2
Bruria Samuel@BruriaSamuel

Meet The Shielded Plasmid🛡️🧬 Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation. It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) nature.com/articles/s4158…

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Asaf Levy אסף לוי اسف ليڤي
Asaf Levy אסף לוי اسف ليڤي@AsafLevyHUJI·
קטע מדהים מיומן ברלין של חסידת אומות העולם רות אנדריאס-פרידריך. בכלל המלצת מעקב חמה על מני אדלר שמביא כל יום קטעים נפלאים מספרי הסטוריה והופך את הפיד למרתק
Meni Adler@meniadler

יום ו, 24 בפברואר 1939 כולם מדברים בברלין על 'ליפטים'. הכוונה איננה למעליות הנוסעים בבתי מלון מפוארים, אלא לארגזי העץ הגדולים שבהם אורזים את מטלטליהם המהגרים ששיחק להם מזלם לעזוב את גרמניה. מזה ששה שבועות מהווה 'הליפט' את הנושא המרכזי לכל שיחה בחוג מכרינו.

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Rafa Pinilla-Redondo
Rafa Pinilla-Redondo@rafapinilla92·
1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 🔗biorxiv.org/content/10.648…
Rafa Pinilla-Redondo tweet media
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Ella Rannon
Ella Rannon@EllaRannon·
My paper on reduced amino acid alphabets for protein language models is out in Bioinformatics! I'll be giving a talk on this on Thursday at ISMB, would love to chat there. #ISMB2026 doi.org/10.1093/bioinf…
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Burstein lab
Burstein lab@BursteinLab·
That's FAMUS: quick, modular, and honest about what it doesn't know. Grab it on the web, through conda, or from source. Huge kudos to 🏆 @GuyShur 🏆, who put the entire thing together. Questions, bugs, or just want to say hi? famus@bursteinlab.org 8/8
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Burstein lab
Burstein lab@BursteinLab·
It annoyed us that annotation tools aren't great at saying "I just don't know". That's a real problem for metagenomes and non-model organisms, where it usually means picking some threshold and hoping for the best. We built FAMUS to try and fix this. doi.org/10.64898/2026.… 1/8
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Sternberg Lab
Sternberg Lab@SternbergLab·
1/11 New preprint from the Sternberg lab in collaboration with the Fernández lab! We are excited to share our structure-function study of DRT10, a bacterial defense-associated reverse transcriptase that synthesizes long tandem-repeat DNA.🧵 More here: biorxiv.org/content/10.648…
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Artem Isaev
Artem Isaev@Artem_Isaev_·
Thrilled to share! We present the structure of a prototypical P2 OLD and reveal that its tRNAse activity is triggered by ssDNA hairpins in phage origins or unresolved termini in RecBCD-deficient cells. Great team effort with Wang, Bikard & Nudler labs. biorxiv.org/content/10.648…
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Kevin Forsberg
Kevin Forsberg@kvnforsberg·
Humans and bacteria share strategies to defend against viruses. We wondered: could they use each other's genes? Yes, both can! Bacteria can use human immune genes to defend against phages AND Human cells can use bacterial genes for viral defense. biorxiv.org/content/10.648…
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Artem Isaev
Artem Isaev@Artem_Isaev_·
Happy to share a preview of recent work from E. Koonin & colleagues, revealing the widespread presence of reparative helicases as central components of prokaryotic immune systems. Written by our talented PhD student Oksana. cell.com/cell-host-micr…
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Artem Isaev
Artem Isaev@Artem_Isaev_·
The CRISPR-Cas system in E. coli K-12 is considered inactive. We questioned whether mobile elements encode anti-CRISPRs against it and found a highly abundant AcrIE9-AcrIE10 tandem and a novel AcrIE13 - an HTH protein more similar to Aca than known Acrs. pnas.org/doi/10.1073/pn…
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Keşfet

@NatureRevMicro @GuyShur @EllaRannon @delafuentelab @elonmusk @BarackObama @taylorswift13 @cristiano