Cristian Coarfa

350 posts

Cristian Coarfa

Cristian Coarfa

@CCoarfa

Associate Professor, Bioinformatics, Dan L Duncan Cancer Center, Center for Precision Environmental Health, Baylor College of Medicine

Houston, Texas Katılım Ekim 2019
402 Takip Edilen263 Takipçiler
Cristian Coarfa
Cristian Coarfa@CCoarfa·
Congratulations Dr Powell @hannpowell96 and to her dedicated mentor @Kaochar2 !
Salma Kaochar@Kaochar2

Our newly minted Dr. Powell!! @hannpowell96 It has been a true honor to be part of your journey and to watch you grow into the remarkable scientist you are today. Congratulations on this tremendous achievement! #ProudPI I am deeply grateful for our exceptional lab family, whose constant support for one another makes milestones like this even more meaningful. @BCMFromtheLabs @BCMDeptMedicine @bcmhouston @BCMGradSchool Greatful to Hannah’s incredible thesis committee @CCoarfa @DamianYoung29 @nelsondl #MargotWilliams @spangas @FredAPereiraBCM

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Ruxandra Teslo 🧬
Ruxandra Teslo 🧬@RuxandraTeslo·
This is an amazing paper from the groups of @anshulkundaje & Scott Boyd and an example of how AI can be used well in biology. Basically, they are able to predict disease status (e.g. lupus, Covid, HIV, influenza) from BCRseq and TCRseq. I think this has great implications.
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Google AI
Google AI@GoogleAI·
Today, in collaboration w/ colleagues at the Institute of Science and Technology Austria (ISTA), we report the first-ever method for using light microscopy to comprehensively map all the neurons & their connections in a block of mouse brain tissue. More →goo.gle/4maUNUs
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Cristian Coarfa
Cristian Coarfa@CCoarfa·
Thank you @naliphd for this exciting collaboration on inflammasome activation in heart failure. This article, among many strengths, follows up very creatively and convincingly on cell-cell communication alterations inferred using scRNASeq data @BCMFromtheLabs
Na Li@naliphd

Better late than never — our paper revealing that fibroblast NLRP3 activation promotes atrial myopathy and diastolic dysfunction is now out in #JACC: Basic to Translational Science! sciencedirect.com/science/articl… 🤝@CCoarfa @StanleyNattel #DobromirDobrev

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Dr. Yong Xu
Dr. Yong Xu@DrYongXu1·
Will move the Xu lab to beautiful Tampa and build a new Center for Molecular Psychiatry at USF. The last group photo at the “fountain” serves as a good reflection of my wonderful 14 years at BCM. Many good memories in the past and many great things ahead…
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Cristian Coarfa
Cristian Coarfa@CCoarfa·
Impactful work with the @PavlosMsaouel lab, based on epigenomic and transcriptomic integration. We know that science is beautiful, and when editors pick our figures for cover it it further confirms it 🫶
Pavlos Msaouel@PavlosMsaouel

👇The @CCR_AACR cover below is a #RenalMedullaryCarcinoma cell expressing MUC16 (CA-125) in green and actin red with overlapping regions in yellow. Photo taken by Menuka Karki #MsaouelLab and also featured in our art contest led by @ED_PhD_ Full article: aacrjournals.org/clincancerres/…

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TMC Digestive Diseases Center
TMC Digestive Diseases Center@tmcddc·
Congratulations to our #GIresearch symposium poster contest winners! 🥇 Luqiong Wang, @bcmhouston 🥈 Lauren Lynch, Baylor College of Medicine 🥉 Sohini Banerjee, Baylor College of Medicine It was close competition! We're lucky to have so many scientists at our institutions 🤠
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Mirrors of Medicine
Mirrors of Medicine@mirrorsmed·
CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation out on Clinical Cancer Research #MsaouelLab" target="_blank" rel="nofollow noopener">aacrjournals.org/clincancerres/… This study explores potential biomarkers 🧬for early detection and disease monitoring of renal medullary carcinoma (RMC), a highly aggressive cancer primarily affecting young individuals of African descent with sickle cell trait🔬. Researchers performed integrated profiling of RMC tumor tissues and identified MUC16, the gene encoding cancer antigen 125 (CA-125), as significantly upregulated in RMC. Elevated serum CA-125 levels were observed in 66% of RMC patients and correlated with metastatic tumor burden. Functional studies demonstrated that restoring SMARCB1, a key tumor suppressor lost in RMC, reduced MUC16 expression. These findings suggest that CA-125 could be a valuable biomarker for disease monitoring and treatment targeting in RMC. #KidneyCancer @KyleBlumMD @JPBertok @DurgaNandTripat @JustinLebenthal @rahulshethmd @priyaraomd @LabGenovese @lazcano_rossana @ALazarMDPhD @CCoarfa @PavlosMsaouel @OncoAlert 🚨
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Cristian Coarfa
Cristian Coarfa@CCoarfa·
Very grateful to see this study published, and also grateful for our collaboration with @PavlosMsaouel lab ! Next, an even deeper dive into the epigenetics of RMC
Pavlos Msaouel@PavlosMsaouel

@OncHahn @andrewjohnsmd @ERPlimackMD @crisbergerot @NazliDizman @BradMcG04 @IamLinghua @rahulshethmd @MikeSerzanMD @kaydaustin @LabGenovese @OAlhalabiMD @perelli_luigi @DrJeffreyGraham @ChadTangMD @salvolarosa @TiansterZhang @d_shapiro1 @QingZhangLab @Daniel_J_George @priyaraomd @UroDocAsh @ChapinMD @drmehrarohit @LisaHenske @DrDanielHeng @ED_PhD_ @DanielFrigo @rovingatuscap @katy_beckermann 5/5 This study establishes CA-125 as a clinically relevant biomarker for RMC, enabling non-invasive disease monitoring. Future directions include exploring MUC16-targeted therapies, and combiningCA-125 with ctDNA for precision tracking. #endRMC #CancerBreakthroughs

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Pavlos Msaouel
Pavlos Msaouel@PavlosMsaouel·
@OncHahn @andrewjohnsmd @ERPlimackMD @crisbergerot @NazliDizman @BradMcG04 @GGiannarini @mjmoussa_ @PauloBergerot @SGoswamiMDPhD @LabGenovese @OAlhalabiMD @ZiadBakouny @DrJeffreyGraham @ChadTangMD @salvolarosa @TiansterZhang @d_shapiro1 @QingZhangLab @DrDanielHeng @priyaraomd @UroDocAsh @ChapinMD @drmehrarohit @LisaHenske @ED_PhD_ @DanielFrigo @rovingatuscap @katy_beckermann @HindRafei 5/5 All figure data are available in the manuscript page & the scRNA sequencing at the GEO webpage: ncbi.nlm.nih.gov/geo/query/acc.… Visualization and real-time interrogation will be made available in the coming months through our Single Cell Research Portal: singlecell.mdanderson.org
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Adam Sharp
Adam Sharp@AdamSharpMedOnc·
Great stuff @AyeshaShafi_PhD 👏
UroToday.com@urotoday

Elevated CBP/p300 expression linked to poor outcomes in advanced #ProstateCancer. @AyeshaShafi_PhD @CPDR_Labs joins @AndreaMiyahira @PCFnews to discuss AR coactivators CBP/p300 in prostate cancer and research revealing that CBP/p300 expression increases as prostate cancer progresses to castration-resistant stages, correlating with poor patient survival. #WatchNow > bit.ly/3PjJkmj

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@renalmedullary @hannpowell96 @Kaochar2 @NganFungLi @bcmhouston @BCMFromtheLabs @OrganoidDiva @sash_ramani