Cancer Immunotherapy retweetledi

🔥 A key question in #CHIP: why do some mutant HSC clones expand while others remain constrained?
🎯 In a new study in @BloodJournal, Lee et al. (@SC_Allison_Yeh) provide a compelling answer: the BM niche in CHIP is a mosaic of “hot” and “cold” cavities, where macrophage-driven remodeling shapes Tet2 HSC clonal fitness.
I had the opportunity to write a commentary discussing the broader implications of this work:
👉 Commentary: doi.org/10.1182/blood.…
👉 Original study: doi.org/10.1182/blood.…
@ASH_hematology
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