Antonio Lucena-Cacace

🫀Our latest research generating cardiac tissues derived from human iPS cells has led to the development of mature human epicardioid organoids exhibiting key features of advanced myocardial and epicardial maturation. It is out today and featured in @NatureComms 🚨🫀

New @ScienceMagazine Why is the heart resistant to cancer? Role of the heart beat! Mechanical force helps protect the heart from cancer science.org/doi/10.1126/sc…

Big data, systems biology & aging, hear it all from Jing-Dong Han (@CAS__Science) @CellSymposia #CSAging2026, Oct 4–6, 2026, Seville. Abstract submission deadline June 5. hubs.li/Q03YBrqC0

A team led by CiRA Associate Professor Yoshinori Yoshida and Antonio Lucena‑Cacace, Associate Professor at Osaka University, has created a first‑class cellular platform comprising mature epicardium and mature heart organoids. #iPSC #CardiacResearch cira.kyoto-u.ac.jp/e/pressrelease…

CiRAの田 雨 研究員、吉田善紀 准教授および大阪大学ルセナ-カカセ アントニオ 准教授らの研究グループは、mTORシグナル伝達の抑制を介してヒトiPS細胞から機能的な成熟心外膜を効率的に生成する新たな手法を確立しました。#iPS細胞 #心臓 #mTOR cira.kyoto-u.ac.jp/j/pressrelease…

This has been incredible work, truly representing faithful developmental modeling that exploits epicardial quiescence and brings hope for the development of preclinical models targeting cardiac regeneration. 💫

Congratulations on such an outstanding paper and to all the team involved, with particular kudos to Yu Tian, our incredible (super 🌟 ) postdoc.

🫀Our latest research generating cardiac tissues derived from human iPS cells has led to the development of mature human epicardioid organoids exhibiting key features of advanced myocardial and epicardial maturation. It is out today and featured in @NatureComms 🚨🫀

@DSheykhkarimli @NRC_CNRC @nzmyachie @FPRoth Congratulations, Dayag! Well deserved. I look forward to seeing how you advance the project! 💪

Thank you @NRC_CNRC for the H.L. Holmes Award to advance tissue-specific drug delivery. Honored and excited to shoulder this responsibility! Blessed with mentors like @nzmyachie and @FPRoth—whose wisdom is the gift that keeps on giving.

@EnriquedeAlava Felicidades, Enrique! Un abrazo enorme!

🎉 ¡Hoy celebro 6⃣0⃣ años de aprendizajes, historias y buen humor! 🎂 ❤️Gracias a quienes me acompañan en esta travesía (y aguantan mis chistes, ocurrencias y proyectos) 🥂¡A por muchos más momentos, brindis y risas! 🥂

@ruljc @KassYoussef_K @NietoAngela Bravo! 👏👏

As a kid, I wanted to discover something to help people. I´m thrilled to see my first contribution to the science community. It has been a titanic team effort led by @KassYoussef_K and @NietoAngela. It also contains a big part of my PhD! Hope you enjoy it. nature.com/articles/s4301…

We are undoubtedly creating new opportunities for iPSCs to make important transitions to patients, offering a broader catalog of derivatives that can help treat intractable conditions🌠

Today, we focus on the fascinating transcription factor SMAD3 and its contribution to mediating differentiation toward the pericyte lineage. Kudos to the whole team 🎉 , especially Yutaro Miyoshi, a trained cardiologist from Kyoto University and PhD candidate!

Our latest research, now published in #StemCellReports #ISSCR, continues to explore epicardial plasticity to derive fate-oriented derivatives 💫 📰⬇️ cell.com/stem-cell-repo…

Dr. Lucena-Cacace (#WPI #PRIMe, Osaka Univ), Dr. Yoshida (#CiRA, Kyoto Univ) and their research group discovered that SMAD3 mediates the specification of human iPS cell-derived epicardium into progenitors for the cardiac pericyte lineage. sciencedirect.com/science/articl…