Héloïse Carion

It's up! Super excited to share our work highlighting the utility of 🔥phage accessory genes🔥 as a tool to elucidate the many layers of phage-host competition. "If you want to know what the host is doing, just ask its virus" - Sukrit, probably

Grad student @CarionHeloise of the Marraffini lab was interviewed by @MolecularCell about her latest paper on the activation of bacterial programmed cell death by phage inhibitors of host immunity. Check it out here: cell.com/molecular-cell…

It is finally out! Muntathar Al-Shimary, Doudna Lab, @bradyfcress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check out the final paper in @NatureMicrobiol nature.com/articles/s4156…

phages are spooky

Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

@ErinHuiting @MDMlab_Paris huge fan. congrats Erin!!!

AntiDefenseFinder is here!✨This project started over a year ago in collab with @MDMlab_Paris, working closely with Florian Tesson. We hope this tool enables the field to explore and discover new insights into anti-defense systems for years to come!

Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: defensefinder.mdmlab.fr. Read below for our insights into the >47K detectable systems📈 tiny.cc/8xrizz

I am thrilled to start my lab as an assistant professor @biozentrum & @NCCR_AntiResist of @UniBasel_en this fall. I will continue my research interest in bacteria & jumbophage interactions. Equally thrilled to be closer to our families after 10+ years.

Excited to share my latest work from the @MarraffiniLab, in collaboration with @PhoebeARice, now online @Nature!! nature.com/articles/s4158… We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria! A thread 🧵: 1/

New preprint from the lab, led by outstanding student Claire Kokontis! (@CKokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one. biorxiv.org/content/10.110…

Hachiman is hot off the (preprint) presses! @owen_t_tuck and I in @doudna_lab present a model for how this broad-activity defense system recognizes genome integrity, a core feature of phage infection. Check out the preprint and Owen's thread for the news:

Yesterday, i had the honor of becoming part of the first Scientific Council for the French President, among a group of 12 incredible scientists. A tad far from my 🦠, but hopefully will help a bit in fostering the role of science & knowledge in our society and democracy.

@jina_leemon @Emy_nim @ucsdbiosciences @HHMINEWS wooooohoooo I love big phages and I cannot lie

It’s finally out!!!! 🎉✨🥂🍾 So proud and grateful to have been part of this work led by @Emy_nim about how the phage nucleus is essential for the replication of these phages and there’s not only one but TWO 2️⃣ organelles?! @ucsdbiosciences @HHMINEWS

I’m really excited to share our new pre-print “Genome-wide Characterization of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi”, with co-first author Muntathar Al-Shimary @doudna_lab and the newly-minted @bradyfcress lab! biorxiv.org/content/10.110… 🧵🧵 1/

Happy to share our new preprint! We used viperins🐍, to understand the conservation and diversification of immune genes across domains of life. A deep dive in the evolutionary history of immune genes shared by prokaryotes and eukaryotes! biorxiv.org/cgi/content/sh…

Class picture time for incoming @RockefellerUniv grad student class!

@vivek_mutalik @carimfraiche @rishihs @ben_a_adler this is a powerful squad

Always nice to hang out with my favorite people in science. @carimfraiche @rishihs @ben_a_adler

The increasing discovery of anti-phage bacterial immune systems (>100 in 5 years!) means an increasing diversity of phage activators. Here, @joeBondyDenomy and I review phage proteins as a prominent ‘pattern of pathogenesis’ and how they activate immunity. tinyurl.com/tmrpwrnk

@joeBondyDenomy @mtcjh @Nicole_D_Marino scientific sorority squat 💯

Lab lunch to celebrate 8y lab anniversary and recent successes for ⁦@mtcjh⁩ and ⁦@Nicole_D_Marino⁩ ! Go Warriors!

It's finally out! 🚀 Before doing a genome-wide screen in P. aeruginosa looking for immune systems, look in these two conserved anti-phage hotspots we named cDHS1 and cDHS2. academic.oup.com/nar/advance-ar… Congrats to all the coauthors! @joeBondyDenomy @ErinHuiting @ARDavidson_UofT

BIG Congratulations to @Nicole_D_Marino who just signed her offer letter at UPenn @PennVet Pathobiology Departmant to start her own lab! The Marino lab opens Jan 1, 2024 focusing on new discoveries at the interface of phage and host immunity! s/o to Chair @BrodskyIgor