Léa Caya-Bissonnette, PhD

Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.110…

Wow, this is great!! Fantastic teaching resource to boot.

For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold! cell.com/current-biolog…

Clustering model parameters across hundreds of synapses, we found five functional subtypes of synaptic dynamics in rodents and six functional subtypes in humans which show qualitative overlap (though based on existing data we don’t expect a perfect overlap). 4/10

MUST read - Amazing work showing functional clusters of short term plasticity! Congrats @jgbeninger 🎉👏

If you're interested in dendritic computation, our most recent findings are just published! With @Z_Friedenberger and at @NatComputSci Direct access: rdcu.be/duzz9 Online: nature.com/articles/s4358…

I’m pretty overdue but this photo reminds me of this exciting day when I had a chance to moderate the trainee talks along with @CayaBissonnette at Centre for Neural Dynamics Research Spotlight organized by @uOttawaBMRI, & enjoy a beautiful talk by @nspruston back in September!

A new theory of serotonin function: it encodes "cumulative future reward" aka state value biorxiv.org/content/10.110… Compared to dopamine, serotonin is a lot more mysterious

Great piece of work by @efharkin_ on serotonin and value encoding 👏

@CayaBissonnette @NeuroNaud @JCBeique Great work! We also have a calcium-dependent model of a different aspect of BTSP here: biorxiv.org/content/10.110…, I'd be interested in hearing your thoughts - maybe you can DM me and we can talk over Zoom some time?

@TMoldwin @NeuroNaud @JCBeique Hi Toviah, i stumbled upon your paper a couple of weeks ago and found it very useful! Congrats on the paper & would love to chat!

Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.110…

@argalloni @NeuroNaud Synapse specificity can still be obtained however, since the ET transformation is contained within the activated synaptic cluster.

@argalloni @NeuroNaud It is possible that IP3Rs bypass the requirement for an additional molecular marker. IP3Rs require calcium and IP3 to open, which may be triggered by two independent sources. The exclusivity of this may depend on location and kinetics of calcium and IP3.

Super cool results! Glad to see the full paper out after the preview we got at Cosyne

@argalloni @NeuroNaud Great question! We have been giving some thoughts to this as well. Indeed, there might a be molecular marker that requires both pre- and postsynaptic activity, and that interacts with ER release, for LTP induction. We have not experimentally tested this.

@CayaBissonnette @NeuroNaud Do you think something might still be categorically different between the two types of Ca source, e.g. maybe synapse activation triggers CaMKII and burst doesn't?

@NeuroNaud Very interesting paper, thanks for sharing! So cool that you are also venturing into the molecular world and building a bridge to the circuit level.

Beautiful work by @CayaBissonnette @NeuroNaud @JCBeique Cellular Substrate of Eligibility Traces biorxiv.org/content/10.110…

@FemtonicsUSA @NeuroNaud @JCBeique Thank you @FemtonicsUSA !!

@CayaBissonnette @NeuroNaud @JCBeique Congrats Léa !!!

Intracellular calcium steadily making its overdue comeback to the big stage 🫡🍿

@JustinKOHare Looking forward to seeing what research you are cooking up next @JustinKOHare !

Amazing work! Congrats @CayaBissonnette, @NeuroNaud and @JCBeique 🥳🤩

Outstanding work by great people - a cellular model of eligibility traces! Check it out 🎉