Daniel Castellano

8.8K posts

Daniel Castellano

Daniel Castellano

@cdanicas

Medical Oncologist. Hospital Univ. 12 de Octubre. Madrid. UCM. Head GU Unit. Executive Member @GUARDconsortitum

Katılım Ocak 2013
1.7K Takip Edilen3.8K Takipçiler
Daniel Castellano retweetledi
Marta Orozco Belinchon
Marta Orozco Belinchon@OrozcoBelinchon·
Is this the end of cisplatin in MIBC? With the results from NIAGARA, KEYNOTE-B15/EV-304, and KEYNOTE-905/EV-303, along with the emergence of ctDNA in IMvigor011, it is becoming increasingly difficult to defend it as the sole backbone of perioperative treatment. Are we truly witnessing a paradigm shift, or is it still too early to move on? #BladderCancer #trendingtopicsinGu @Uromigos @Uro_Oncologist @tompowles1 @docjavip @karima_oualla
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OncoAlert
OncoAlert@OncoAlert·
News From Industry: TALAPRO Update in #ProstateCancer Source Businesswire and Pfizer buff.ly/HTeEtmv Pfizer reports the Phase 3 TALAPRO-3 trial showed that talazoparib plus enzalutamide significantly improved radiographic progression-free survival in patients with HRR-mutated metastatic hormone-sensitive prostate cancer, exceeding the target hazard ratio. Benefits were consistent across BRCA and non-BRCA mutations. An interim analysis indicated a strong trend toward improved overall survival. @montypal @crisbergerot @DrDanielHeng @apolo_andrea @DrChoueiri @PGrivasMDPhD @TiansterZhang @HHammersMD @ravikanesvaran @neerajaiims @amerseburger @sonpavde @drenriquegrande @scserendipity1 @Silke_Gillessen @EfstathiouEleni @tompowles1 @BraunMDPhD @nataliagandur @cdanicas @brian_rini @AOmlin @nataliagandur @acampsmalea @BRicciutiMD @FernandoOnco @ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK @MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88 @PaulJiL @DaisukeKotani @DraMartinezLago
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Álvaro Pinto
Álvaro Pinto@dralvaropinto·
Impact of Circulating Tumor DNA and Copy-Number Alterations on Clinical Outcome in Relapsed/Refractory Germ Cell Tumors Treated With Salvage High-Dose Chemotherapy | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…
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MV Chandrakanth
MV Chandrakanth@ChandrakanthMv·
🔥 EMBARK final OS — mature data, real impact Enzalutamide + ADT improves survival in high-risk BCR prostate cancer 👉 HR 0.60 | ~9% absolute gain Enza alone? Controls disease… but no OS benefit 👉 Early intensification matters #MVOnco #ProstateCancer #Oncology
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Advanced Prostate Cancer Consensus Conference
Progress in Shortening Treatment Courses for Bone Metastases in a Statewide Quality Consortium advancesradonc.org/article/S2452-… This statewide consortium study evaluated radiation therapy ☢️fractionation for bone metastases after implementing quality measures promoting single-fraction and ≤5-fraction regimens. Among 4,477 patients, use of shorter courses significantly increased over time. Factors such as later treatment year, patient condition, and treatment characteristics influenced adherence. Results highlight successful adoption of shorter regimens while underscoring the complexity of clinical decision-making in optimizing palliative radiation therapy. #ProstateCancer @LukeMHiggins @DrKCParadis @OncoAlert 🚨 @Silke_Gillessen @AOmlin @weoncologists
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OncoAlert
OncoAlert@OncoAlert·
Our Coverage from #GU26 Continues We are proud to have Dr. @Clara__Steiner 🇩🇪@DanaFarber 🇺🇸share with you her poster Presented in San Francisco Pilot phase I trial of an implantable microdevice for in vivo evaluation of drug response in renal cell carcinoma. This pilot phase I study evaluated implantable microdevices (IMDs) delivering microdoses of multiple drugs directly into renal cell carcinoma tumors. In 10 patients, CT-guided IMD placement before surgery proved safe and feasible, with successful tissue analysis in most cases. The approach revealed spatial, drug-specific effects on apoptosis, proliferation, and immune composition, demonstrating the potential of IMDs to guide personalized therapy selection while avoiding systemic toxicity. #KidneyCancer @DrChoueiri @MattMossanen @MichelleDunno17 @bergsa83 @MikeSerzanMD @BradMcG04 @srviswanathan @stusilverman @VincentWenxinXu @motzermd @DrIacovelli @DrYukselUrun @elena_verzoni @tompowles1 @montypal @crisbergerot @DrDanielHeng @apolo_andrea @PGrivasMDPhD @TiansterZhang @neerajaiims @amerseburger @drenriquegrande @BraunMDPhD @cdanicas @brian_rini @AUC3_Official @nataliagandur @MarcMachaalani @Mustafajsalehmd @NazliDizman @DrYukselUrun @yekeduz_emre @WeiweiBian @ReneeSaliby @eddy_saad @marc_eid @pablombarrios @WDKhatoun @Jad_El_Masri @lilli_ash @RashadNawfal @RazaneHChehade @elioibrahim8 @NafehGaelle @shaye_carver @zeyun_lu @SylvanBacaLab
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GUARD Consortium
GUARD Consortium@GuardConsortium·
#InsightClínico 🔬 En cáncer renal metastásico, combinaciones IO + IO o IO + TKI continúan consolidándose como estándar en primera línea La selección del tratamiento debe considerar: ✔ Riesgo pronóstico ✔ Perfil de toxicidad ✔ Comorbilidades ✔ Objetivos terapéuticos del paciente La personalización es clave. #RenalCellCarcinoma #mRCC #Oncology @DrFelixGuerrero @cdanicas @dralvaropinto @drenriquegrande @fcounago @docjavip @BerUrologia @DrJaVallejo @Maroto5Pablo @nachoduranm @RodriguezAntona @AnaPlatabello1
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Gil Morgan, MD
Gil Morgan, MD@weoncologists·
🌐 Gran noticia: El 6.º Coloquio @OncoAlert 🚨 ya está DISPONIBLE EN TU IDIOMA! 🇪🇸🇮🇳🇵🇹🇮🇹🇫🇷🇺🇦🇯🇵🇲🇽🇸🇦🇷🇺 1⃣8⃣Idiomas hablados y subtitulados disponibles ENCUENTRALOS AQUI👉 oncoalert360.com/multi-language… @GuardConsortium @cdanicas @drenriquegrande @DrJaVallejo @dralvaropinto @mjuanfi81
OncoAlert@OncoAlert

🌐 Big news: The 6th OncoAlert 🚨Colloquium is NOW AVAILABLE IN YOUR LANGUAGE!! 🇪🇸🇮🇳🇵🇹🇮🇹🇫🇷🇺🇦🇯🇵🇲🇽🇸🇦🇷🇺and many more SPOKEN & WITH CAPTIONS in 1⃣8⃣Languages ALL VIDEOS HERE 👇👇oncoalert360.com/multi-language… Top oncology experts. Global reach. Zero barriers. Watch the 50-sec video to learn how #BreastCancer @hoperugo🇺🇸 @matteolambe🇮🇹 @Icro_Meattini🇮🇹 Dr. Roberto Salgado 🇧🇪 @ErikaHamilton9 🇺🇸 @DrSGraff 🇺🇸 @itrisabel🇪🇸 @ESSOnews @ElisaAgostinett 🇧🇪 @RebeccaDSing 🇸🇬 @LazarPo31787807 🇷🇸 #LungCancer @GlopesMd🇺🇸 @jillfeldman4 🇺🇸 @UmbertoMalapel1 🇮🇹 @BRicciutiMD 🇺🇸 @UOzkerim 🇹🇷 @DrMirallas🇺🇸 GU Oncology @brian_rini 🇺🇸 @declangmurphy 🇦🇺 @KidneyCancer🇺🇸 @salvolarosa @Silke_Gillessen🇨🇭 @RenuEapen🇦🇺 @nataliagandur 🇦🇷 @seanmcbride 🇺🇸 @jAvallejo 🇪🇸@GuardConsortium GI Oncology @BenWestphalen 🇩🇪 @graokane 🇮🇪 @GIMedOnc🇺🇸 @NiuSanford 🇺🇸 @ARosen380 🇺🇸 @Erman_Akkus 🇹🇷 @realbowtiedoc 🇺🇸 GynOnc @NicoloBizzarri 🇮🇹Vanda Salutari 🇮🇹 @AStrojnaMD 🇩🇪Alejandra Martinez 🇫🇷 @CoquardRay 🇫🇷Christina Fotopoulou 🇬🇧Giorgia Garganesse 🇮🇹 @ChargariC 🇫🇷 @PaulJiL H&N🇬🇧 @DrJasonWestin Lymphoma🇺🇸 @FadiHaddad_MD Leukemia🇺🇸 @Abdallah81MD Multiple Myeloma🇺🇸 @NassifElise Sarcoma 🇺🇸 @DrBetofMDPhD Melanoma🇺🇸 Our Partners @ESGO_society @ESSOnews @CancerCareMASCC @SIOGorg Our Collaborators @APCCC_Lugano @gu_onc @Uromigos and more and more to come.......

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Advanced Prostate Cancer Consensus Conference
Genomic Profiling in Localized Prostate Cancer: Associations With Biochemical Recurrence and Response to Salvage Radiotherapy onlinelibrary.wiley.com/doi/10.1111/ca… Comprehensive genomic profiling in localized #ProstateCancer identified alterations in six genes🧬 (PTEN, BRCA2, POLD1, ERBB3, MYC, SETD2) associated with biochemical recurrence and worse recurrence-free survival after prostatectomy. Alteration-positive patients showed higher stage and recurrence rates. BRCA2, especially with SETD2 co-alteration, predicted poorer outcomes. These findings suggest genomic profiling may refine risk stratification, though further validation is needed before guiding management in localized disease. @OncoAlert 🚨 @Silke_Gillessen @AOmlin @weoncologists
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GUARD Consortium
GUARD Consortium@GuardConsortium·
La investigación colaborativa es el motor del avance en tumores genitourinarios. En GUARD Consortium conectamos especialistas para impulsar estudios independientes, formación y generación de evidencia clínica. 👉 Síguenos también en LinkedIn y forma parte de la comunidad científica. #GUARDConsortium #ClinicalResearch #OncologyNetwork @DrFelixGuerrero @cdanicas @dralvaropinto @drenriquegrande @fcounago @docjavip @BerUrologia @DrJaVallejo @Maroto5Pablo @nachoduranm @RodriguezAntona @AnaPlatabello1
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Cancer Cell
Cancer Cell@Cancer_Cell·
The cellular orchestra of CAR T success dlvr.it/TRX8rM
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GUARD Consortium
GUARD Consortium@GuardConsortium·
Desde #GU26, la Dra. @mjuanfi81 presenta una nueva cápsula informativa sobre el ensayo fase 3 KEYNOTE-B15/EV-304 en cáncer de vejiga músculo-invasivo candidato a cisplatino. La combinación perioperatoria de enfortumab vedotin + pembrolizumab redujo el riesgo de recurrencia o progresión en un 47% y aumentó la tasa de respuesta patológica completa (56% vs 32,5%). Resultados que podrían redefinir el estándar perioperatorio en MIBC ⤵️
OncoAlert@OncoAlert

COLLEAGUES AT #EAU26 Our friends from @GuardConsortium 🇪🇸Deliver another Great Informational Capsule, this time direct from #GU26 🇺🇸 We are proud to introduce our Colleague @mjuanfi81 Discussing the Presentation of: KEYNOTE-B15/EV 304 The phase 3 KEYNOTE-B15 trial evaluated perioperative enfortumab vedotin plus pembrolizumab versus standard cisplatin-based chemotherapy in 808 patients with muscle-invasive #BladderCancer eligible for cisplatin. The combination reduced recurrence or progression risk by 47% and improved pathologic complete response rates (56% vs 32.5%). Although higher-grade toxicities occurred, results suggest this regimen may improve survival and represent a potential new perioperative standard, warranting further comparative investigation. buff.ly/LIBgTVi @cdanicas @dralvaropinto @drenriquegrande @nachoduranm @DrJaVallejo @abraocantoMD @docjavip @AlvarezMa89031 @DrFelixGuerrero @BerUrologia @AnaPlatabello1 @AlvarezMa89031 @scocmem @OncBrothers @Helena_de_Palma @F_lopez_campos @Dav_Lorente @EurUrolOncol @tompowles1

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OncoAlert
OncoAlert@OncoAlert·
A reminder that #APCCC26 🇨🇭is coming in Late April and is OPEN TO EVERYONE, not just the Panel members and 👉️ REGISTER HERE: buff.ly/XpCWPdR 🚨 Enjoy 20% off when registering for both APCCC & IPCS 2026 Awarm invite to the Advanced Prostate Cancer Consensus Conference #APCCC26 in Lugano🇨🇭 Event Details: 📍 Palazzo Congressi, Lugano, Switzerland 🎟️ Register here 🎓 Credits requests: SGU – SSU, SSMO, SRO, SGMN In an era of rapid innovation and expanding treatment options for advanced #ProstateCancer , APCCC provides a vital forum for clinicians and researchers to address complex clinical questions where high-level evidence is limited. Over two days, the world’s leading experts will engage in high-level presentations, debates, and discussions to clarify and conceptualize the current landscape of care, with a focus on areas of controversy or uncertainty. The insights and consensus developed during the meeting are later published in European Urology, helping shape global standards. Creating new opportunities for younger investigators & the next generation of leaders in advanced prostate cancer! @Silke_Gillessen & @AOmlin @fabioturco92 @Prof_IanD @drjefstathiou @Prof_Nick_James @ChrisSweens1 @BertrandTOMBAL @ZilliThomas @neerajaiims @bjartell @PBlanchardMD @BourlonMaite @Albert0Briganti @cdanicas @Ecastromarcos @mdesantis234 @nachoduranm @drlouiseemmett @stefanofanti4 @fontev1 @Nicola_Fossati @marty_gleave @ProfKHerrmann @DrMHofman @BarbaraJereczek @ravikanesvaran @FacsRaja @LoebStacy @quimmateo @DrRanaMcKay @amerseburger @CaPsurvivorship @declangmurphy @DrPaulNguyen @WilliamOhMD @piet_ost @DrSpratticus @cnsternberg @DrYukselUrun Ping @nataliagandur @OncoAlert 🚨
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Julian Chavarriaga
Julian Chavarriaga@chavarriagaj·
#EAU26 Dr. von Amsberg on when to introduce PARPi: mHSPC or should we wait until mCRPC? 🧬 BRCA1/2-mutated mHSPC behaves differently. • Poorer prognosis • Less benefit from ARPIs/docetaxel • PARP inhibitor combinations show the strongest rPFS signal (emerging OS) in BRCA1/2 💡~1 in 4 men never receive another line of therapy → effective treatments may need to move earlier, not later. @uroweb @UroToday
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UroToday.com
UroToday.com@urotoday·
Circulating and urine tumor DNA dynamics predict minimal residual disease and recurrence risk in locally advanced #UTUC: CURATE-UTUC – A multicenter prospective longitudinal cohort study. Presentation by Jiwei Huang. #EAU26 written coverage by @zklaassen_md > bit.ly/473DONU @Uroweb
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@DocMeetings - Urology
@DocMeetings - Urology@docmeetings·
PRostate cancer guidelines 2026 update. Digital rectal exam NOW no more recommended for Asymptomatic men SO NO MORE FOR Screening Important for standing and for early diagnosis for SYMPTOMS only @Uroweb
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Giulio Francolini
Giulio Francolini@GiulioFrancoli1·
🚀 Largest prospective SABR cohort in inoperable RCC. Pooled FASTRACK trials show 98% local control at 5 years, excellent CSS, low ≥G3 toxicity and no late safety signals. A durable, non‑invasive, kidney‑sparing option—now poised for randomized comparison vs surgery. #EAU26
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