Grainne O'Kane

888 posts

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Grainne O'Kane

Grainne O'Kane

@graokane

Medical Oncologist; clinical and translational researcher pancreatic and hepatobiliary cancers. Views are my own 🇮🇪🇨🇦

Katılım Ağustos 2013
622 Takip Edilen1.9K Takipçiler
Grainne O'Kane retweetledi
Precision-BTC-Network
Precision-BTC-Network@PrecisionBTCnet·
It’s #WorldCCADay! 🌍 We are proud to join the global #RecognizeCCA campaign to raise awareness for cholangiocarcinoma as a primary liver cancer. Watch our new video to see how Precision-BTC is working to advance research and improve outcomes for patients: 🧬📺
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Grainne O'Kane retweetledi
Michèle Bourke
Michèle Bourke@michele_bourke·
The Liver Cancer Team @svuh are delighted to collaborate with @IrishCancerSoc to highlight #WorldCCADay 2026 with an information stand for staff and patients at Centre Point today, raising awareness of CCA 💚 @hseNCCP @graokane @CharityAMMF #LightIrelandGreenForCCA
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Global Cholangiocarcinoma Alliance@CCA_Alliance

Did you know Cholangiocarcinoma (CCA) is a rare and aggressive liver cancer, with cases and CCA-related deaths rising each year? Tomorrow, February 19 is #WorldCCADay. Let’s unite to raise awareness of this devastating disease. #RecognizeCCA #Cholangiocarcinoma #CCA

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Grainne O'Kane retweetledi
ILCA
ILCA@ILCAnews·
One week until registration opens for #ILCA26. Our global liver cancer community will gather again to share evidence, discuss challenges, and build collaborations. Stay tuned and save your seat the super-early-bird rate 🎫 ilcalive.org/annual-confere… @docamitgs
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Grainne O'Kane retweetledi
OncoAlert
OncoAlert@OncoAlert·
TODAY February 4, 2026: The 6th Annual OncoAlert Colloquium 🚨GI Malignancies REGISTER👉 buff.ly/MjxFItr GI Day 3 Feb 4, 2026 As ALWAYS ✅Patients Included @BenWestphalen 🇩🇪 @GIMedOnc 🇺🇸 @Graokane 🇮🇪 @NiuSanford 🇺🇸 @realbowtiedoc 🇺🇸 @ARosen380 🇺🇸 @Erman_Akkus 🇹🇷 John Herrera Kok🇪🇸 Marco Inama 🇮🇹 @pashtoonkasi @marklewismd @AndresC27622123 @manjuggm @stacy_hurt @KoheiShitara @GillSharlene @FLordick28391 #OncoAlertAF @nataliagandur @acampsmalea @BRicciutiMD @HHorinouchi @FadiHaddad_MD @Abdallah81MD @FernandoOnco @ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK @MarioBalsaMD @DrMirallas @OscarTahuahua @UOzkerim @DrRishabhOnco @Onco_Cifu88 @PaulJiL @DaisukeKotani @DraMartinezLago Our Partners @ESGO_society @ESSOnews @CancerCareMASCC @SIOGorg
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Grainne O'Kane retweetledi
Syed A. Ahmad
Syed A. Ahmad@SyedAAhmad5·
Surgical quality and technique is always important. Is there a cancer where LOCAL surgery is talked about more than pancreas ca? Is there a cancer more SYSTEMIC than pancreas ca?
Mike Pishvaian@MPishvaian

#GI26 This discussion is one worth saving, especially for Medical Oncologists like me👇👇👇 @villesallinen from @helsinkiuni have a really thorough, and understandable review on surgical techniques for pancreatic cancer resection 🙏Thank you for the teaching👨‍🏫

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Lee M. Ocuin MD, FACS
Lee M. Ocuin MD, FACS@TheNotoriousHPB·
@SyedAAhmad5 Nope. We have maxed out local therapy for this disease space. All the debated around arterial resections and MIS Whipple are a testament to the Law of Diminishing Returns. None of it matters unless we have better drugs.
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Grainne O'Kane
Grainne O'Kane@graokane·
Liver-directed Tx #CRCLM👏 more🔧for MDT #GI26 ❤️molecular/biology each talk ➡️Rads as std & future role ➡️IR-PVE &Y90/ablation NB COLLISION ➡Transplant debate: selection 🔑need control!-but in right pt high OS; more CRCLM will have sx/other @ASCO @OncoAlert @_ILTS_ @ldawsonmd
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Grainne O'Kane
Grainne O'Kane@graokane·
Liver transplant unresetable #CRCLM ➡️retrodata Belgium, 29pts 2016-2025; median age 56 ➡️86% BRAF/RAS WT; 79% left/rectum ➡️ living donor 24%; mFU 20.5mo ➡️38% recurrence-73% lung ➡️2yr RFS 55%; 2yr OS 90% ⭐️prospective registries/protocols needed #GI26 @ASCO @_ILTS_ @OncoAlert
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Grainne O'Kane
Grainne O'Kane@graokane·
Ph2 durva+olaparib #PDAC #GI26 ➡️BRCA1/BRCA2 (80%) &PALB2 ➡️no PD on platinum ➡️85% liver met;prior sx 40% ➡️ORR 35%, mDoR14.5mth ➡️mPFS 6.7; mOS 22.2mth ➡️anemia common (G3 10%) ⭐️defining optimal Tx HRD-PDAC ?CTLA-4v PD-L1 👏🏻@MacarullaTeresa @Florian_Castet @ASCO @OncoAlert
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Grainne O'Kane
Grainne O'Kane@graokane·
Updated CheckMate 9DW #HCC Nivo+ipi v len/sor ➡️follow up 52mths ➡️1 in 4 pts BCLC B ➡️mOS 23.7 v 20.6mths; ➡️48mth OS rates 31 v18% ➡️G3/4 TRAEs 25 v 13% ⭐️interesting hepatitis data 19% early event ~6 weeks ‼️close monitoring @ASCO @OncoAlert @ILCAnews
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Grainne O'Kane
Grainne O'Kane@graokane·
Rph2 Penpulimab (PD-1)/anlotinib (TKI)+GnP v GnP #PDAC n=177 ➡️ 8 cycles GnP d1,8 q21 then maintenance ➡️nb 39% no liver mets ➡️ORR 50v 26% mPFS7.8 v 4.5mo ➡️mOS 13.9 v 10.5mo ? Pop diff with IO responses ?molecular @ASCO @OncoAlert #GI26
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Grainne O'Kane
Grainne O'Kane@graokane·
Rph2 #PDAC Elraglusib (GSK-3betai) + GnP v GnP #GI26 ➡️n=155 no diff in ORR or mPFS ➡️mOS 10.1 v 7.2mo (eligibility broad) ⭐️matched bx - ⬆️CD8 /NK and GrzB+ cells ?some effect here but biomarkers 🔑 @ASCO @OncoAlert
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Grainne O'Kane
Grainne O'Kane@graokane·
Liver Power Hour 👏 #HCC #GI26 MDT 3 cases with learning pts 👇 1. Post LT recurrence-‼️challenging Surgery/LRT where possible 2. BCLC B options- Surgery/LRT(Y90/SBRT/TACE)/systemic 3. Single lesion VP1/2 -getting to Sx Y90 v Systemic-note high risk recurrence @ASCO @OncoAlert
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Grainne O'Kane
Grainne O'Kane@graokane·
Targeting resistance RASi #GI26 ➡️diff genetic patterns allele specific v pan-RASi ➡️Amp KRASm consistently challenge-can we intercept? ➡️non-genetic:cell plasticity, RNA, histologic ➡️reshaping TME: promising strategies inc vaccines👇 ➡️combining RTKs @OncoAlert @ASCO 👏🏻amazing
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Grainne O'Kane
Grainne O'Kane@graokane·
Targeting KRAS #GI26 ➡️moving beyond #PDAC/#CRC & G12C need in #CCA ➡️allele specific, pan-KRAS and pan-RASi ➡️challenges in Switch II pocket constraints/G12R ➡️resistance means combos needed - chemo NB ‼️basal-like v classical @ASCO @OncoAlert
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Keşfet

@curecc @cureGBC @OHSUKnight @svuh @IrishCancerSoc @hseNCCP @CharityAMMF @JCO_ASCO