Krishna Chinthalapudi

Structural basis of human Nav1.5 gating mechanisms | PNAS pnas.org/doi/10.1073/pn…

In print today @ScienceMagazine Laser phase plate improves structure determination of small proteins by cryo-EM | Science science.org/doi/10.1126/sc…

New publication by @Heissler_Lab and @CellAdhesion lab titled, AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin published in Circulation Research ahajournals.org/doi/10.1161/CI… @OSUWexMed @OhioStateDHLRI

@S_HamiltonLab Congratulations 🎊

Thrilled to share the Hamilton lab has received our first Notice of Award for an NIH R01; ‘The roles of endoplasmic reticulum stress in cardiac arrhythmias’. I am so grateful to NHLBI and those who supported us to get here. Stay tuned for postdoc position…

What the industry is hiding about nicotine pouches: ☠️ Addictive: designed to hook you fast 🧪 Toxic: unregulated levels of nicotine ❤️ Increased risk of cardiovascular disease 🧠 Damages brain development No smoke. No smell. No warning. Around 160 countries have NO specific regulations for nicotine pouches. The industry is exploiting every gap. It's time to expose them. #TobaccoExposed

@ktr_nakanishi Congratulations Kotaro!

Our cryo-EM structures reveal how human AGO2 loads a duplex, selects one strand over the other, unwinds the duplex, and ejects the passenger. Notably, target-assisted passenger ejection (𝐓𝐀𝐏𝐄) enhances RISC maturation! cell.com/molecular-cell…

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature nature.com/articles/s4158…

@Alushin_Lab @Nature Congratulations! Glad this important work is finally out.

A new study from @Heissler_Lab titled MYH9 mutations differentially stabilize non-muscle myosin II filaments and induce distinct cellular aggregation phenotypes published in Cellular and Molecular Life Sciences #Sec8" target="_blank" rel="nofollow noopener">link.springer.com/article/10.100… @OhioStateDHLRI @OhioStateMed

Exciting study from Deschenes and Chinthalapudi @CellAdhesion labs. Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5. nature.com/articles/s4146… @NatureComms @OSUWexMed @OhioStateDHLRI @OhioStateMed

Basic Experimental Studies in Humans (BESH) Will No Longer Be Considered Clinical Trials by the NIH grants.nih.gov/grants/guide/n…

A new collaborative paper from @Heissler_Lab and @CellAdhesion lab. Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation rupress.org/jcb/article/22… @OhioStateDHLRI @OSUWexMed

@GarikipatiSrik2 @OhioStatePCB @osuresearch @OhioStateDHLRI @OhioStateERIK @OhioStateMed Thank you

@OhioStatePCB @CellAdhesion @osuresearch @OhioStateDHLRI @OhioStateERIK @OhioStateMed Congratulations, Krish!

New funding alert from NIH. Dr. Krishna Chinthalapudi @CellAdhesion received two R01s. For more details reporter.nih.gov/search/FxQemqL… reporter.nih.gov/search/IoOc-Uu… @osuresearch @OhioStateDHLRI @OhioStateERIK @OhioStateMed

Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @SenateDems @SenateGOP @NIHDirector_Jay @hubermanlab wsj.com/politics/polic… Trump Administration Puts New Chokehold on Billions in Health-Research

We are walking the Ullswater Way with @OscarsCharity in May. Learn more and donate here: justgiving.com/team/thalia #braintumours #childhoodcancer #cancer

@PDBeurope @BiophysicalSoc Congratulations Hsiang-Ling! We are very proud of you. Thanks wwPDB for the award.

Congrats 👏 Hsiang-Ling Huang, Giovanna Grandinetti, Sarah Heissler & Krishna Chinthalapudi on the wwPDB Foundation award at the 2025 @BiophysicalSoc Meeting for their work on mechanisms of dysferlin-mediated membrane repair! 🔗 #67be07c041f3196e2505ea6d" target="_blank" rel="nofollow noopener">wwpdb.org/news/news?year… #bps2025 #BPSAnnualMeeting

NIH has stopped considering new grant applications, delaying decisions about how to spend millions of dollars. The freeze occurred because the Trump administration has blocked the NIH… npr.org/sections/shots…

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases. I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known. People can contact me directly at my first name (as written in my profile) at octant.bio.

@ArgallPhd Congratulations guys! We are so happy for you.

Two big announcements for the Argall home! 1. Our son, Aiden, arrived last week weighing 8lbs 6oz! He’s perfect and we’re so lucky. 2. I found out the same day that I officially received the AHA Postdoctoral Fellowship!

I’m looking for a motivated postdoc to join my lab with a structural biology background. Reach out to me if you are interested in the structure-function studies of actin cytoskeleton and membrane repair processes.