Dr. Ceri Fielding

Comprehensive review on COVID-19: etiology, pathogenicity, and treatment. September 2025 frontiersin.org/journals/medic…

Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, or related. Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology

The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes nature.com/articles/s4146… @NatureComms @a_pichlmair 🇩🇪

Acaban de secuenciar al virus que ha causado el brote de Hanta en el crucero. virological.org/t/complete-seq… Resulta que es prácticamente idéntico al virus que causó la epidemia que duró 4 meses en Argentina en 2018. nejm.org/doi/10.1056/NE… No es un virus nuevo ni su transmisión de 🧵

🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵

Autoantibodies cause autoimmune disease, shape infection outcomes, and alter cancer immunotherapy. But what role might they play in neuropsychiatric disease? In our new preprint, Katlyn Nemani and @JillianRJaycox take on this question in schizophrenia. 🧵 biorxiv.org/content/10.648…

BREAKING🔔 The 57th paper from G2P-Japan🇯🇵 is out at Cell @CellPressNews🦇!! We elucidated the virological characteristics of a new bat coronavirus identified in Thailand🇹🇭 The debut work by “G2P-Asia🌏”. Please repost🔥 cell.com/cell/fulltext/…

A mechanistic breakthrough (imo) came a few months back where hyperphosphorylated tau (a hallmark molecular feature of dementia) was shown to bind HSV-1 directly, suggesting that the molecular pathology of AD could be a chronic response to infection. 3/n x.com/rust_ruslan/st…

A history of viral encephalitis is one of the strongest risk factors for developing dementia. With @JacobJacobog02, Yifan Chen, @RNA_Life, and @RyanDhindsa, we refine this link by describing a neuronal cell type that can reactivate HSV-1 in humans 1/n biorxiv.org/content/10.648…

Awesome title! Living rent free in your head: resident memory T cells academic.oup.com/immunohorizons…

"In this study, we present a genome-scale map of genetic interactions in the human haploid cell line HAP1, based on CRISPR-based perturbation of ∼4 million gene pairs. The resulting network comprises ∼89,000 high-confidence gene-gene interactions" doi.org/10.1016/j.cell…

"Beyond hepatitis D virus: the discovery of animal deltaviruses, their diversity, helpers and their position in an expanding world of circular RNA replicons " , enjoy a fresh review coming out from our lab (Zoé Denis, an amazing PhD student as first author) sciencedirect.com/science/articl…

Congrats to the lab of Dr. Dalan Bailey (@Morbillivirus) on their new @Nature study! 👏 They show that some bat-derived #alphacoronaviruses can enter human cells via CEACAM6, suggesting geographically widespread viruses with potential for zoonotic transmission. 🦇 go.nature.com/4nddaJr

Drs. Philipp Henneke, Sebastian Baasch, and co-authors discuss how cytomegaloviruses (CMVs) manipulate myeloid immune cells to establish postnatal infection, and explore strategies by which CMVs breach the placental barrier and access the fetal brain. 🧠 bit.ly/3OHBqpU

Does identifying thousands of plasma proteins mean more biology? Not always. Over half of 210 published datasets contain contamination markers reported as disease biomarkers.

Recent studies support a model in which mutated #EpsteinBarr virus infects hematopoietic stem or lymphoid progenitor cells in the bone marrow, establishing latent infection that persists as these progenitors differentiate into T/NK cells. @BloodPortfolio bit.ly/4tSYzoD

Nature research paper: Synthetic super-enhancers enable precision viral immunotherapy go.nature.com/4cuHuLA

AlphaFold predicts millions of protein complexes, but how many are real? We built LUCIA, a rapid cell-free assay that answers this in <3 days. Applied to HSV-1, we: ✅ Discovered dozens of novel interactions ✅ Provided the first experimental benchmark for ipTM scores ✅ Went from prediction → interface mutation → functional proof Explore 23,215 models across 3 herpesviruses: herpesfolds.org/herpesppis 🔗 Preprint at: doi.org/10.64898/2026.…

Excited to share our @NatureGenet paper nature.com/articles/s4158… #CRISPR activation, Perturb-seq, and a new type of optical screens (in situ Perturb-seq) reveal RNA/protein-based interventions to “normalize” (rather than activate) immune responses for clearance of cancer and virally infected cells. Congratulations to @reece_akana, Jeehyun Yoe, Olivia Laveroni, and the rest of the team!

Charged molecular glue discovery enabled by targeted degron display: nature.com/articles/s4158…