Dr. Ceri Fielding

@biorxivpreprint Memory NK cell generation to cytomegalovirus infection is regulated by age and T cell immunity @DonnaFarber3 @Columbia biorxiv.org/content/10.648…

Artificial intelligence-guided design of LNPs for in vivo targeted mRNA delivery via analysis of the spatial conformation of ionizable lipids go.nature.com/4bhLOxl

Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice nature.com/articles/s4146… @NatureComms 🇨🇳

Single-molecule peptide sequencing through reverse translation of peptides into DNA go.nature.com/4sRPr2K

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo. A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models. #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… a 🧵

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts @jhumimmunity @esiborghe @AurelieCobat @ShenYingZhang1 @casanova_lab @grvsadrian @trespidifra rupress.org/jhi/article/2/…

Mitochondria acidify lysosomes through membrane contacts @uofcincy @SunLabUCin sciencedirect.com/science/articl…

A high-affinity nanobody that disrupts the CLEC12B–lipoprotein lipase axis, thereby revitalizing NK cell activity and suppressing tumor progression in preclinical models @NatImmunol 🇨🇳 nature.com/articles/s4159…

How specific are therapeutic monoclonal antibodies, really? In our new paper, @Yile_Dai led a collaboration with Adimab to profile 174 FDA-approved and clinical-stage mAbs against 6,172 human extracellular proteins. What we found surprised us.🧵 sciencedirect.com/science/articl…

The dog cancer vaccine has been all over X the past few days. It got me thinking about other famous N-of-1 experiments. As you can probably imagine, self-experimentation has a long, wild history in science. Here are some of the most notable. 🧵

Engineering an in vivo charging station for CAR-redirected invariant natural killer T cells to enhance cancer therapy go.nature.com/3NDA5QB

@MalmbergLab commentary on the recent Carrington Lab paper A genetic set-point for natural killer cells nature.com/articles/s4159… @NatImmunol nature.com/articles/s4159…

Review: The dual roles of natural killer cells in liver immunity and tolerance: Implications for health and disease journals.lww.com/hepcomm/fullte…

HPV-positive tumors harbor a specialized NK cell population that supports patient survival, whereas HPV-negative tumors produce signals that block NK cell function mdpi.com/2072-6694/18/5… 🇨🇳

Can you do coding AND virology? Then boy do we have a PhD for you @ImperialInfect findaphd.com/phds/project/m…

Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan @CellReports cell.com/cell-reports/f… 🇨🇳

Today in @Nature we introduce INSTALL, which bypasses mammalian DNA immune sensing to enable non-viral DNA integration with recombinases—a step toward safe, scalable, and mutation-agnostic genome editing. 🧬 🧵(1/13) nature.com/articles/s4158… @BKleinstiver @CGM_MGH @MassGeneralNews @harvardmed

Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis pnas.org/doi/full/10.10…

Identifying genetic and cellular connections and distinctions among 15 autoimmune diseases using an in-silico approach 🇨🇳 nature.com/articles/s4385…

Grier, Heimall et al. @CHOP_Research report that mutations in DNA helicase RECQL4 can cause immunodeficiency, including #SCID. The T cell defects are intrinsic to the hematopoietic system and amenable to hematopoietic stem cell transplant. hubs.la/Q045TGMp0