Chai Gopalasingam

user.spring8.or.jp/sp8info/?p=429… SP8利用者情報にAIと電顕使った化合物デザインの解説書きました。インテージヘルスケアの吉森さん、名大創薬の横島さん、SP8の電顕チームにすごくお世話になりました。感謝。

Excited to finally share the #cryoEM structure of the iron #nitrogenase complex out today in @NatureSMB. This thread serves to prime you on some of the amazing biochemistry required to make molecular nitrogen (N2) bioavailable! nature.com/articles/s4159…

@AlexmagCryo @DCI_EM Awesome work! Which detector did you use and how many movies/final number of particles were there in the final reconstruction?

Today is the second anniversary of DCI-Lausanne, and we're thrilled to share the incredible news: Our amazing team (especially Sergey and Inay), has just gifted us with the extraordinary achievement of a 1.12A ApoF structure from the Titan without an energy filter! 🚀 @DCI_EM

Meet the PyShell!🥧🐚 Diatom pyrenoids fix up to 20% of the Earth's #CO2🌏. We discovered that their Rubisco is encased in a tight protein lattice that is essential for efficient carbon fixation and cell growth🌱 Super excited to share our new preprint📜: biorxiv.org/content/10.110…

@structure_bio36 Congrats on the great work and nice to have met you in Hakata recently! ☺

We are happy to share our latest paper published in Nature Communications. We report the structures of HCA2-Gi and HCA3-Gi with multiple compounds. See 👇"Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding" #article-comments" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

Excited to share our preprint: “Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase” in which we obtained a structure of a 46-kDa membrane protein to 2.2 Å resolution without fiducials. tinyurl.com/zycuw3p6

Come join us in Glasgow! These new posts will help us improve our service to users and make sure we are really wringing the most out of our instrumentation. I think there is still ground to cover with our CRYO ARM/Apollo combination and it'll be fun!

It is my pleasure to announce the @EMBO course on “In situ structural biology by Cryo-FIB and Cryo-ET” taking place @MPI_Biochem from 8.-14. April 2024. If you are interested in learning about cryo-ET and cryo-FIB including lift-out, apply by December 8th! meetings.embo.org/event/24-in-si…

大量の回折データから異なる構造情報を見いだす方法 －タンパク質の多様な構造決定を実現するためのガイドライン－（プレスリリース） — SPring-8 Web Site spring8.or.jp/ja/news_public… #SPring8

AI使って胃プロトンポンプの構造に基づいた阻害剤デザインしました。創薬の横島さん、理論創薬研究所の吉森さん、SPring-8 cryoEMとの共同研究です。いつの日かkabeprazanが作れるといいな... nature.com/articles/s4200…

特任研究員（常勤）の公募：電子線構造生物学研究室｜大阪大学蛋白質研究所 protein.osaka-u.ac.jp/offer/20230822/ クライオ電子顕微鏡による構造解析を目指した試料作成が可能で、感染症発生のメカニズム解明の研究活動、及び外部利用課題にも意欲を持って対応できる研究者 | 最長で 2027年3月31日まで

#CryoSPARC v4.3 is now available! ❄️⚡️ Featuring an all-new suite of #cryoEM data cleanup tools, new micrograph grid display and interactive job improvements, and a detailed performance benchmarking and comparison system! Changelog: cryosparc.com/updates 1/5

蛋白研主催のセミナーです。初学者向けですが、良かったら参加してくださいませ 【8/31・9/1開催】2023年度 大阪大学蛋白質研究所　単粒子解析コース　※オンサイト＆オンライン開催 protein.osaka-u.ac.jp/seminar/202308…

When a student asks about number of turns of copper coil in an EM lens and you don’t know…. CM120: 588. Thanks to our #workshop @MPIbp ! @thermosciEMSpec #cryoEM

Outstanding talk @CTLSlifeScience #CLTS2023 Juan Garcia Vallejo @amsterdamumc 'Behind every user fee there is a personal/professional story' Getting the financial model right in facilities makes a huge difference to individuals/projects. Ability to pay ≠ research quality

We suffered two problems on our Krios/Arctica instruments related to a pressure gauge called PPal. Here a picture of the faulty PPal from the Arctica. But then...what is a PPal and how it measures pressure? These two questions kept me busy for a while, a thread to follow 👇

Japan is one of only 4 countries to ever win the FIFA Women’s World Cup ⚽️🏆 And yet, less than a month out, there is no broadcast deal Get the damn deal done, FIFA & 🇯🇵 Broadcasters Girls deserve something to aspire to, The footballers deserve to be showcased Get it done!