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Charles F. Sherrod IV, M.D., M.Sc.
347 posts
Charles F. Sherrod IV, M.D., M.Sc.
@CharlesFoxIV
T32 CV Outcomes Research and General Cardiology Fellow @MidAmericaHeart via @BrownMedicine. Interested in health status, #HCM, and clinical trials.
Kansas City, MO Katılım Aralık 2018
682 Takip Edilen362 Takipçiler
I matched into Cardiology at Houston Methodist Hospital! Beyond thrilled! @HMHCardioFellow
Grateful to my family and to my colleagues and mentors at @umkcIM whose support made this possible.
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留学先での仕事をJACCばらんで取り上げてもらいました😊
ISCHEMIA 試験のpost-hoc解析でInvとConそれぞれのSAQの長期的な変化を解析しました。
手前味噌ですが、血行再建を検討する際、患者さんに具体的にどのタイミングで症状が改善するのか⁉️よりクリアに説明できると思います。ぜひご覧ください👍
Mitsuaki Sawano, MD, PhD, FACC@MitsuakiSawano
📢 Ep.33 #JACCばらん 「患者の“症状の旅路（Patient’s Journey）”を描く：ISCHEMIA試験からみた狭心症の軌跡」 🎙️ゲスト：池村 修寛 先生（国家公務員共済組合連合会 立川病院／前 Saint Luke’s Mid America Heart Institute 🇺🇸@MidAmericaHeart） 📝 “Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease” 🎥Youtube：youtube.com/watch?v=d61yaV… 🎧 Podcast：jacc.org/digital-conten… 📺 Video：jacc.org/digital-conten… 🔍 ISCHEMIA試験データを用い、慢性冠疾患（CCS）の狭心症を有する患者 2,977例を対象に、 侵襲的治療 vs 保存的治療での**症状改善の軌跡（trajectory）**を解析。 💡 潜在クラス軌跡モデル（Latent Class Trajectory Analysis） により、 個々の「症状の経過パターン」を6つに分類👇 1️⃣ 急速に狭心症が消失（Rapid resolution） 2️⃣ 徐々に改善（Gradual resolution） 3️⃣ 早期改善後に軽度症状が持続 4️⃣ 重度からの改善 5️⃣ 軽度〜中等度でほぼ変化なし 6️⃣ 重度のまま変化なし 🔸侵襲的群では「急速改善」＋「早期改善」が過半数を占め、 🔸保存的群では「軽度で変化なし」が最多。 🔸女性や喫煙者は「改善しにくい軌跡」に属しやすい傾向。 💬 臨床的意義： ・平均値では見えない“患者ごとの回復の形”を明らかに。 ・症状持続群には追加治療・SDM（Shared Decision-Making）が必要。 ・狭心症の「軌跡」を把握することで、フォローアップ戦略を個別最適化できる。 🔗jacc.org/doi/10.1016/j.… @jspertus @MitsuakiSawano @Nobu0129 @jspertus @SS_cardiol @KenEjiri @sk2798 @JACCJournals @ACCinTouch #JACCばらん #ISCHEMIA #狭心症 #冠動脈疾患 #PRO #心血管疾患 #循環器 #CardioOutcomes #患者報告アウトカム #Cardiology
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@MasriAhmadMD It’s remarkable that despite a baseline KCCQ OSS of >90 that there were large drops in OSS with bisoprolol
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A clinical trial of bisoprolol and verapamil in nHCM. As you should expect by now, BB look bad.
Presented at ESC by Dr. Bjerregaard
#CardioTwitter
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Congrats to @MidAmericaHeart fellow Andrew Girard on this important publication! @BrettSperryMD @AndrewJSauer @stacyfarr
#HFpEF #KCCQ
JCF Intersections@JCFINT
New in JCF–I: Do echo changes in diastolic function reflect patient health status in HFpEF? 📉 In this TOPCAT sub-study of 211 patients, changes in echo parameters over 12 mo were not linked with KCCQ changes. 🔗 bit.ly/3JVsz1d #HFpEF #PatientOutcomes #JCFIntersections
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@drjohnm Shared decision-making is the basis for decisions with trade offs. I think respecting patients’ preferences and empowering their voices when choosing between revasc, valve intervention, and initial oHCM treatments is highly important. I think our patients feel similarly…
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One more thing: shared decision making has been a huge net negative in real life. We did not need this concept as it is inherent in proper doctoring. Always was.
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@AnilMakam Kinda curious - any thoughts about the OCTAVE or OVERTURE trials? I often think about ARNI in the context of those rather than exclusively in other ACE/ARB when thinking about entresto.
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Amazing. Cheaper is better. I just wish I knew if it worked
Mark Cuban@mcuban
If you take Entresto, we now have the generic and it starts at $33.75 ! It's probably lower than your deductible or Coinsurance. So check it out with your doctor !
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Congrats Omar!!
Omar Cantu Martinez, MD@OmarCM_MD
Presented today @crfheart #NYValves2025 on the potential application of patient-reported health status (KCCQ) after M-TEER or TAVR.🫀🔧 Special thanks to my mentors @chetanhuded @jspertus @suzannevarnold. @saintlukeskc @MidAmericaHeart 📸See attached photo for key points.
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@hvanspall @djc795 @mad_sters @jspertus While not extensively validated, the KCCQ-SES has been linked to outcomes.
pmc.ncbi.nlm.nih.gov/articles/PMC10…
John and I wrote the editorial as well. I think it’s an interesting relationship.
pmc.ncbi.nlm.nih.gov/articles/PMC10…
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@djc795 @mad_sters @jspertus Thx & yes, I understand it is a 2 question section within kccqe therefore tagged you. I did see psychometrics on this, though 2 questions will not provide discrimination to test the effect of the planned intervention. I’m working with JS on another project so will ask.
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If you are a health services researcher, and can recommend a validated scale to assess #SelfEfficacy in patients with #HeartFailure (with psychometric properties published), please share a link.
(and here is my sunset for you in exchange)
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Congrats, Omar! Great news for patients and great mentorship from @AndrewJSauer
Andrew J Sauer MD@AndrewJSauer
At #ESCHF2025 🇷🇸 @MidAmericaHeart fellow Dr Omar Cantu-Martinez presents #CAREHKinHF real-world registry: >2,300 HF pts w/ hyperK risk with 9% on clinician selected patiromer. Reduced severe HK and trend toward more optimal GDMT. Take-home: early K⁺ control keeps GDMT on & protects heart + kidneys
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Charles F. Sherrod IV, M.D., M.Sc. retweetledi
Understanding patient-reported outcomes in obstructive hypertrophic cardiomyopathy (oHCM) is vital for managing treatment effectively.
We recently validated the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) in this population. Here’s why it matters:
A quick🧵
doi.org/10.1016/j.card…
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Charles F. Sherrod IV, M.D., M.Sc. retweetledi
Congratulations TIARA Scholars implementing evidence into practice!
👏🏻
Today was the Certificate Ceremony & Keynote on the
“Future of Implementation Practice” with @AnneSales4 @HealthcareUMKC @FrontiersCTSI
🩺📖💕
👑
healthcareinstitute.umkc.edu/professional-t…
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@hvanspall I think we met at the equity in heart transplant project event in Philly! Maybe there’s an opportunity to explore some of these modeling strategies together. 😊
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@CharlesFoxIV Patients do not wish to be in the hospital either. I don’t think this is an either / or scenario. All of these important patient priorities can be considered in endpoint selection.
PS. You work in a very good place with very good friends / collaborators of mine, by the way.
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Is anyone aware of any #RCT that demonstrated the efficacy of any intervention in any CVD on the primary #endpoint of “days alive and out of the hospital”?
If so, please share.
(And what #breakfast are you having to fuel the clinical workday?)
#DAOH #TrialDesign
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@hvanspall 2/2 Patients tend to prioritize QoL and death, and have mixed feelings about hospitalization. Alive and out of the hospital tries to blend things but we have way better tools like the KCCQ and SAQ that can reduce sample size and amplify the patient voice better.
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@hvanspall 1/2 To me this emphasizes the need to prioritize PROs and should raise questions about hospitalizations as a patient centered endpoint. There is so much variability in who gets hospitalized, how long they may stay, and their dispo plan.
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congrats to the entire international STOP-CAD team! @ShadiYaghi2 @ShuLiqi ahajournals.org/doi/10.1161/ST…
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Charles F. Sherrod IV, M.D., M.Sc. retweetledi
📢 The Kansas City Cardiomyopathy Questionnaire (KCCQ-23) vs. NYHA Class in Obstructive Hypertrophic Cardiomyopathy
🔹 our brief report in @JCardFail explores how KCCQ-23 scores align with NYHA class in patients with obstructive hypertrophic cardiomyopathy (oHCM).
💡 Key Findings:
✅ KCCQ-23 scores inversely correlate with NYHA class but show wide variability within classes 📊
✅ Moving from NYHA III to II showed greater improvement in KCCQ scores than II to I 🔄
✅ Supports greater use of KCCQ-23 for precise patient-reported outcomes 🎯
🩺 These insights can help clinicians interpret KCCQ scores better for patients with oHCM
🔗 Read more:
onlinejcf.com/article/S1071-…
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Charles F. Sherrod IV, M.D., M.Sc. retweetledi
.@stephencookmd, et al., conducted a voluntary survey of #ACCFITs & #ACCEarlyCareer cardiologists to evaluate #LGBTQ+ representation, potential sources of mistreatment & measures of wellness among the cardiovascular workforce.
🔗 bit.ly/4gkTjms #ACCPride #JACCAdvances
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Deeply honored to become a Heme/Onc fellow at @NorthwesternMed starting next July!
Super grateful to my family, friends, mentors, @umkcIM, and everyone who has supported me throughout the long journey.
@NUHemOncFellow @hemeoncfellow #Match2025 #HemeOnc
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