Chris Nabel, MD PhD

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Chris Nabel, MD PhD

Chris Nabel, MD PhD

@ChrisNabelMD

Oncologist @MGHCancerCenter, clinical interests in thymoma, thymic carcinoma, lung cancer and metabolism. Opinions are my own, tweets not medical advice

Boston, MA Katılım Kasım 2020
122 Takip Edilen170 Takipçiler
Kristopher Sarosiek
Kristopher Sarosiek@CellDeathLab·
➡️Join us at the next BCDI meeting on Monday Oct 2nd at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions with @chendi on inducing apoptosis in NSCLC and @nabel on identifying novel therapy targets in thymic epithelial tumors. More info: BostonCellDeath.org
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Chul Kim
Chul Kim@chulkimMD·
Excited to present our research showing high Trop-2 expression in thymic epithelial tumors @LungCaJournal Great work by Dr. Vincent Yeung, former fellow @LombardiCancer A multicenter IIT of sacituzumab govitecan in TETs under design by @jennifermarksmd! bit.ly/3s3Z6cH
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Chris Nabel, MD PhD
Chris Nabel, MD PhD@ChrisNabelMD·
@LFTapias @ElliotServaisMD @NEJM A lot of assumptions made from ICD codes without any mention of reviewed op notes or path reports. Many thymomas get coded w D49.89 which is non-specific, may result in underreporting
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Luis Felipe Tapias, MD
Luis Felipe Tapias, MD@LFTapias·
@ElliotServaisMD @NEJM I am surprised there has not been more debate! Thymectomy for parathyroid assumed a complete thymectomy (rarely so) and all patients that had cardiac surg assumed to have a thymus still in place (sometimes a significant part removed by some surgeons or severely devascularized)
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Elliot Servais, MD, FACS
Elliot Servais, MD, FACS@ElliotServaisMD·
Yup, agree 100%. @NEJM - help me understand. This is NEJM quality? A retrospective comparison of heterogeneous groups without control for thymectomy indication... #tssmn #IsThisScience #UnsupportedConclusion nejm.org/doi/full/10.10…
Stephen Cassivi, MD FRCSC FACS FRCS@StephenCassivi

@LFTapias @NEJM Luis, You are correct. The stark conclusion drawn, as well as that in the accompanying editorial, are not warranted by this study’s findings. The comparison groups are different enough that the difference in outcomes could as easily been due to having myasthenia or a thymoma …

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Luis Felipe Tapias, MD
Luis Felipe Tapias, MD@LFTapias·
@pnatarajanmd @NEJM Routine thymectomy? Careful, look at the indications for surgery in the appendix. Would have been nice to have had a discussion with a surgeon to understand the populations being studied. Study patients and controls did not have “similar cardiothoracic surgery”.
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Pradeep Natarajan
Pradeep Natarajan@pnatarajanmd·
Routine thymectomy is often performed with various surgical procedures. However, compared to matched controls, those who underwent thymectomy had greater risk of cancer & all-cause mortality at 5y f/u nejm.org/doi/full/10.10… @NEJM
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Chris Nabel, MD PhD
Chris Nabel, MD PhD@ChrisNabelMD·
Hopefully our study will fuel future efforts on rewiring metabolism of KRAS in lung cancer. Project was a fun collaboration w Kwok Wong lab @nyulangone and postdocs-turned-PIs Hua Zhang @UPMCHillmanCC and @DrCDowling @RCSI_Irl, fitting with this month’s special on Lung Ca in 🇮🇪
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Chris Nabel, MD PhD
Chris Nabel, MD PhD@ChrisNabelMD·
In tumor spheroids, CB-839 synergized w ACY1215 in KL but not KP, suggesting a window for exploiting differences. The synergy held up in mouse tumors as well
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Keşfet

@CellDeathLab @chendi @nabel @chendi_li @kochinstitute @MIT @harvardmed @MGHMedicine