Simone Cimminelli

In tech we went from Steve Jobs to no jobs thanks to ai

Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested. And today the cancer signal drops. 12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%. Cancer joins a list that already includes heart disease (SELECT, 20% MACE reduction), kidney failure (FLOW, 24% slower decline), sleep apnea (SURMOUNT-OSA, FDA-approved), addiction (BMJ, 600K veterans, 18-25% reduction across substances), and liver disease (86% fat clearance). Tumors express GLP-1 receptors. Activate them and NF-kB drops, apoptosis rises. The drug isn’t just shrinking fat. It’s talking directly to the cancer. One drug class. Designed for blood sugar. The biology keeps finding uses the designers didn’t predict.

@dividendology The trade off is an illusion

There is some truth to this.

@JesseTinsley stopbuyingdomain.com

Just bought a new domain today… ~$100k (all cash). Can anyone guess which domain?

@mewwts Yes and I am not going back. To me alcohol was primarily a great social lubricant. I have morphed in a more self confident men over the decades. I still enjoy going out very much and I am happy to do it regularly even alcohol free. The day after I feel fresher.

Anyone I know stopped drinking alcohol completely? Considering it

My crm syncs emails, calendar, tasks, deals and WhatsApp. It’s so good that I leave my Pa taking care of it. Only give her input in a 40’ early morning meeting. She is not allowed to reach out to me during the day. She send me a recap acting as agenda every evening. Never been so productive and free to focus to my actual work

Lately, I've been advising founders to vibecode their own CRM that reads their emails, calendars, and keeps things up to date in real time. It took me 2 hours to create my own using Claude Code (and I've never coded in my life). Am I crazy for suggesting this or do others agree?

@Jason i'm in

We started an AI founder twitter group... reply with "I'm in" if you're a founder and want to be added

@boringmarketer 💯

anyone else feel like Claude Code with opus 4.6 is lobotomized and noticeably dumber lately

@euronationalizt Book me in

We should create our own Euro Summer: Lock in edition Rent an Italian villa with pool for 2 weeks. Bring your friends. Cook every meal. Nap in the middle of the day. Drink wine. Eat bread. Build. Lock in. Who's with me?

Opus 4.6 is now retarded

X is now a 💩 TikTok clone

@PeterJ_Walker Likely the f.o. will not have to read all the follow ups, also on their side will use an agent. :)

You're an emerging VC who just had a great coffee chat with a new family office. You shake hands, part ways, start walking back to the office. Flip open Claude on your phone. "Hey Claude, pull our current fund performance against Carta benchmarks, then give me a list of the top 5 investments from the fund & package it up into a deck with some written highlights for this lovely family office manager I just met." Never write a dull follow-up again

@Rikardoplav how much?

🇮🇹This is not just a villa. It’s an entire private estate - with its own historic residence, chapel, and land. In Tuscany, near the Ligurian border. Here’s what that looks like 👇

Congratulations AG Blanche. Now you have 30 days to release the rest of the files before becoming criminally liable for failure to comply with the Epstein Files Transparency Act.

“Mr. Trump and Mr. Epstein knew that I was 13 years old.” Given the latest news, this deserves another look by everyone. It’s only two pages. Also please share widely on all platforms. Save the screenshots to your phone and share on your own platforms. We need Truth to be clear.

@OliverMolander they are all walking zombies

More of this. Mark my words: we're entering a new European super cycle. Outcomes will be larger and more frequent.

@agupta wrong alignment

Fun update: I got tired of disliking every email client I’ve ever used and built my own. It’s called Exo (for exoskeleton). It’s Claude Code for my inbox. It manages my inbox for me, and it’s open source. Link to repo + some notable features in thread!

Australians can now live & work freely in the EU for 4 years and vice versa That means they now have 𝒎𝒐𝒓𝒆 EU rights than British people. Free movement offered millions of us fantastic opportunities but Brexiteers slammed that door shut, most shamefully on their own children

@adcock_brett basically another note taking app

Today I'm excited to introduce Hark, a new artificial intelligence lab building the most advanced, personal intelligence in the world We've been in stealth for 8 months, assembling one of the greatest AI and hardware teams on the planet I want to explain why I started Hark and what we're focused on I've spent the last 3 years working on the hardest AI challenge imaginable: giving AI a humanoid body. On the digital side, I've been using all the existing LLM chatbots - and I have to say, they feel incredibly dumb to me AGI, in the limit, should feel like a sci-fi movie. It should be able to listen and talk. It should have persistent memory and be highly personalized. It should see and touch the world. But we're far from this today We are crafting a new interface to AGI. Intelligence that lets you offload your mental workload into a system that begins to think like you and sometimes ahead of you We started Hark with one goal: build the world's most advanced personal intelligence - paired with next-generation hardware designed to serve as a universal interface between humans and machines hark.com

🚨🇱🇧 BREAKING: Israel is completely ETHNIC CLEANSING civilians in Lebanon and world is 100% silent on this. Don't be silent. Repost this. Stand with Lebanon.

Las Vegas understands the assignment‼️ Don’t get distracted‼️