Colin Lee

610 posts

Colin Lee

@ColinYCLee

MB-PhD candidate • Bioinformatics and immunology • @Cambridge_Uni • @Kings_college • @Gates_Cambridge alumnus 🇸🇬🏃🏻⚽️

Katılım Kasım 2020

517 Takip Edilen495 Takipçiler

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Colin Lee@ColinYCLee·24 Oca

Interested in tumour immunity, dendritic cells and immunotherapy? Excited to share our study on CCR7+ dendritic cells (DCs) in cancer out today, a joint effort between @LabWithers and @ClatworthyLab. (🧵 1/8) nature.com/articles/s4146…

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KelvinTuong@KelvinTuong·9 Şub

Sneak peak of upcoming sc-dandelion 1.0.0 release! Read, process and plot 1M single-cell AIRR data e.g. @ParseBio's data in <15min without GPU! #singlecell #bcr #tcr

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Colin Lee@ColinYCLee·4 Şub

Great to see this really cool piece of work now out in @NatureGenet led by superstar @elizabetha_coop. Check it out!!

Elizabeth Cooper@elizabetha_coop

I am excited to share our latest research out today @NatureGenet; here we discovered childhood brain tumours instruct cranial hematopoiesis and identify a clinically relevant mechanism to re-educate the skull bone marrow. nature.com/articles/s4158…

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Elizabeth Cooper@elizabetha_coop·28 Eyl

Very excited to share our latest preprint – We find that childhood brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. A thread 1/11 biorxiv.org/content/10.110… @Gilbertson_Lab @CRUK_CI @LPTrustUK @BrainTumourOrg

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Jennifer Guerriero, PhD@JennGuerriero·20 Eyl

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.

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Cancer Immunology Research@CIR_AACR·23 Eyl

In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade doi.org/10.1158/2326-6… @ColinYCLee @ClatworthyLab and @LabWithers

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Colin Lee@ColinYCLee·21 Ağu

If interested, do also check out our previous related work using the Kaede model to study the temporal dynamics of *DCs* (doi.org/10.1038/s41467…), *NK cells* (doi.org/10.1038/s41467…) and *T cells* (doi.org/10.1084/jem.20…); review article (doi.org/10.1111/imcb.1…).

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Colin Lee@ColinYCLee·21 Ağu

We identify spatially, temporally and functionally distinct tumour-associated macrophage (TAM) populations that undergo rapid changes following tumour infiltration. Immune checkpoint therapy promotes pro-inflammatory IFNγ-driven responses in newly-entered monocyte-derived TAMs.

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Colin Lee@ColinYCLee·21 Ağu

Our latest study using the photo-convertible Kaede model to track tumour-infiltrating leukocytes and their changes over time is now out in @CIR_AACR! doi.org/10.1158/2326-6… @ClatworthyLab @LabWithers

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Colin Lee@ColinYCLee·10 Haz

@KelvinTuong @daniyal_jafree Awesome @daniyal_jafree that you had the time to go! Have been reading your notes on EPIC 😅

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KelvinTuong@KelvinTuong·10 Haz

Chili crab experience with @daniyal_jafree in Singapore :)

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KelvinTuong@KelvinTuong·6 Haz

We have a PhD position opening for Australian domestic students interested to work at the intersection of immunology, data science, and paediatrics! Check out the full description here! linkedin.com/posts/ian-fraz… @YUmmunology

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Cathrine Sant@cathrine_sant·8 Nis

CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! nature.com/articles/s4158…

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Masud Husain@MasudHusain·29 Mar

Thank goodness people are waking up to the fact that there is a crisis for clinical research in the UK @FT High on the list are the bureaucratic processes that have become such an obstacle to getting things done

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Waggoner Lab@LabWaggoner·27 Mar

Review @jacionline @ClatworthyLab @ColinYCLee Profiling immune cell tissue niches in the spatial -omics era jacionline.org/article/S0091-…

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ksa 🏴‍☠️@kosa12m·12 Mar

Most rigorous ML paper

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Colin Lee@ColinYCLee·7 Mar

Check out our discussion (@ClatworthyLab) on the use of Spatial Transcriptomics for investigating immune niches in this month's issue of @jacionline

Journal of Allergy and Clinical Immunology@jacionline

The March issue of JACI is now online! Check it out here: jacionline.org/current This month's theme focuses on Spatial Transcriptomics. Read the Editors' Choice summaries from the March issue here (free to read/download): authors.elsevier.com/a/1khQaKs2xLkVL

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Journal of Allergy and Clinical Immunology@jacionline·5 Mar

Recent developments in high-throughput spatial -omics technologies have facilitated a more comprehensive understanding of tissue immunity. Learn how they have generated new insights in translational immunology and what the future might hold. bit.ly/41tH15E

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Colin Lee@ColinYCLee·25 Şub

Huge! 🎉🎉

KelvinTuong@KelvinTuong

Veryy happy to share that I got lucky this round and was successful in my #NHMRC Investigator Grant! Thanks to my past and present mentors @YUmmunology @ClatworthyLab @teichlab who helped shaped my career thus far!

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KelvinTuong@KelvinTuong·24 Şub

Translational Research Institute@TRI_info

Congratulations to TRI-based researchers/clinicians sharing in @nhmrc support to advance work in kidney disease, blood cancer and gut health (pictured from right): @DWJohnsonNeph, @KelvinTuong and @AyeshaShah717. @UQ_News, #FrazerInstUQ, @qldhealth

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Mary-Ellen Lynall@MLynall·22 Şub

Fancy a 4-year post-doc in Cambridge, working in both the biggest biomedical centre in Europe @psychiatry_ucam @CambridgeBRC and the genetic powerhouse of the @sangerinstitute?

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Brian S. Kim@itchdoctor·20 Şub

Cancer neuroimmunology is real. Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis | Nature nature.com/articles/s4158…

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Keşfet

@ParseBio @NatureGenet @elizabetha_coop @Gilbertson_Lab @CRUK_CI @LPTrustUK @BrainTumourOrg @ClatworthyLab