Curtis Helms

@louisanicola_ So when should a female take the p-tau217 test⁉️ I know a 50+ female where her dad just died of Alzheimer’s 🫤

Two out of every three Alzheimer's patients are women. For decades, we blamed longer lifespans. The neuroscience tells a very different story. Menopause isn't just a reproductive transition—it's one of the biggest neurological events in a woman's life, and Alzheimer's pathology often begins 20–30 years before the first symptom. In this solo episode, I break down the science every woman needs to know before she reaches menopause. 0:00 Two Out Of Three Alzheimer's Patients Are Women 0:37 The Estrogen Shield: Four Things It Does For Your Brain 2:13 What Happens When Estrogen Begins To Fall 3:01 Menopause Is A Neurological Event, Not A Reproductive One 3:31 Why Women Develop More Tau Than Men 4:15 Alzheimer's Starts Decades Before Symptoms 5:02 When Perimenopause Collides With Brain Aging 5:44 The Symptoms Women Are Told To Ignore 6:42 The APOE4 Risk Every Woman Should Know 8:59 Why Resistance Training Beats Cardio For Brain Protection 9:31 Irisin, BDNF & Fertilizer For Your Brain 10:37 Two Strength Sessions A Week Changed Brain Structure 11:16 When Cardio Can Work Against You 13:36 The Glymphatic System: How Your Brain Cleans Itself 14:53 Why Amyloid Is Cleared During Deep Sleep 15:56 Why Women Lose Deep Sleep At The Worst Time 16:37 Deep Sleep Matters More Than Total Sleep 18:41 The HRT Timing Window 18:56 32% Lower Risk vs 38% Higher Risk: Same Therapy, Different Timing 20:56 Why We're Still Following Advice From 2002 21:05 Why APOE4 Carriers May Benefit The Most 23:19 The MIND Diet & A 53% Lower Alzheimer's Risk 24:20 The Omega-3 Dose Most Women Get Wrong 25:17 Berries, Anthocyanins & The Foods To Cut 27:38 The Cortisol Crisis: The Thread Through Everything 28:58 The Estrogen–Cortisol Feedback Loop 30:18 The "Healthy" Routine That's Quietly Hurting Your Brain 31:08 Seven Layers, One Message: This Is Preventable

@celinegounder I guess you have a point 🫤 When her insurance stopped covering brand-name GLP-1s, she started buying a compounded powder version from China and reconstituting it at home. Meanwhile, her eating became more disordered, governed by strict rules wsj.com/health/wellnes…

The wellness world is right that Big Pharma lied for money. That distrust is earned. But the fix they're selling is unregulated powders nobody tested. That's Big Pharma with the guardrails off, same profit motive, no safety checks. The fix for a captured system is honest rules, not no rules. Save and send to a skeptic. Read & subscribe for free: celinegounder.com celinegounder.com/p/peptide-prov…

Say less.

@MohammedAlo Wegovy (semaglutide): Approved for chronic weight management in adolescents aged 12 and older with obesity (BMI ≥95th percentile for age and sex). It is used with diet and exercise 🤨

🚨 1 in 5 American children has obesity right now. That is not a future problem. That is happening at your dinner table tonight. Here is the number every parent needs to hear. A child who carries obesity into adulthood faces 3 times the risk of heart disease compared to a child

@brittanybussemd I’m gonna #BeatOprah at my next marathon 🤨

Every day, we are learning that humans have incredible untapped potential. What are your predictions for the next barrier broken in sport or longevity?

@louisanicola_ Hey Doc 👋 Should every 40+ get the p-tau-217 test 🤔

Dementia can look the same while biology differs From 1,016 blood proteins researchers built a 21 protein panel that distinguished Lewy body dementia and FTD from controls GFAP was the only protein consistently higher across every Alzheimer’s comparison Precision starts here

@MohammedAlo You meant Wegovy ⁉️ b/c Ozempic is for T2D 🫤

🚨 Ozempic cut heart attacks by 20% in people with zero diabetes. Not weight loss patients. Not diabetics. Overweight adults with heart disease. Here is what the science actually says. The SELECT trial enrolled 17,604 patients. None had diabetes. Semaglutide still reduced heart

Your gym-bag peptides and fentanyl come out of the same Chinese chemical trade. Same factories, same "research only" labels, same crypto checkouts. No one tests what's in the vial. Save and send to anyone trying peptides. Read & subscribe for free: celinegounder.com celinegounder.com/p/peptide-prov…

Tesamorelin is an FDA-approved 44-amino acid GHRH analog that stimulates natural growth hormone release, reduces visceral fat, and supports metabolic health without direct HGH injections. What Tesamorelin Is Tesamorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH), consisting of 44 amino acids with a trans-3-hexenoic acid modification that enhances stability and resistance to enzymatic breakdown in plasma. Unlike direct human growth hormone (HGH) injections, tesamorelin works upstream, signaling the pituitary gland to release growth hormone in a pulsatile, physiologic pattern, preserving the body's natural feedback mechanisms. It is sold under the brand name Egrifta and is the only FDA-approved GHRH peptide. Mechanism of Action When administered subcutaneously, tesamorelin binds to GHRH receptors in the anterior pituitary, triggering the release of endogenous growth hormone (GH). This GH then stimulates the liver to produce Insulin-like Growth Factor 1 (IGF-1), which mediates many of tesamorelin’s anabolic and metabolic effects. By mimicking natural GHRH, it avoids the continuous IGF-1 elevation and potential suppression of endogenous GH production associated with exogenous HGH. Clinical Uses Tesamorelin was originally developed and FDA-approved for reducing excess abdominal fat in HIV-positive adults with lipodystrophy. Clinical trials demonstrated a 15–18% reduction in visceral fat over 26 weeks, with improvements in body composition and lipid profiles. Beyond its approved indication, tesamorelin is increasingly used off-label in bodybuilding, anti-aging, and metabolic health contexts to enhance lean muscle retention, reduce visceral fat, and support IGF-1 levels. Dosage and Administration The standard FDA-approved dose is 2 mg daily via subcutaneous injection, typically administered before bed or in the morning on an empty stomach. Newer formulations, such as Egrifta WR, allow weekly reconstitution and reduced injection volume. Benefits Targeted visceral fat reduction without affecting subcutaneous fat, Improved body composition and lipid metabolism, Enhanced IGF-1 levels supporting anabolic and recovery processes. Safety and Side Effects Tesamorelin is generally well-tolerated. Common side effects include injection site reactions, mild joint pain, and transient edema. Serious adverse effects are rare but may include allergic reactions. It is not a weight-loss drug and should not be used for general obesity management. Regular monitoring of blood parameters is recommended during therapy. Summary Tesamorelin is a therapeutic GHRH analog that safely stimulates natural growth hormone release, reduces visceral fat, and supports metabolic health. Its FDA approval, clinical trial validation, and physiologic mechanism distinguish it from other GH peptides and exogenous HGH therapies, making it a valuable option for both medical and off-label applications in body composition and anti-aging strategies .

Before you spend a dollar on a wellness product, ask three questions. Was it tested in actual people? Did it work? Is it safe, and who's checking? "It's a peptide" answers none of them. If the seller can't answer, you're the experiment. Save and send to anyone trying peptides. Read & subscribe for free: celinegounder.com celinegounder.com/p/peptide-prov…

@HillaryLinMD The dietary restrictions will keep me straight with my 16:8 🤨

This may be the biggest gamechanger for longevity medicine since GLP-1s. Heart disease has shaped my family. My dad survived a massive heart attack and eventually needed a heart transplant. My grandfather spent the last six years of his life bed-bound after a stroke. Then my own LDL came back at 192. A PCSK9 injection changed my trajectory. Every other week is manageable. Most people would rather take a pill. The FDA just approved Lipfendra, the first oral PCSK9 inhibitor. LDL fell 56–59% vs placebo. ApoB fell about 50%. Injectable-class potency in a once-daily tablet. The biology is not new. What feels new is the possibility that far more people may actually use it. The safety signal so far is reassuring. It is not a perfect pill. You take it in the morning on an empty stomach, then wait 30 minutes. Product-specific cardiovascular outcomes are still pending. If the outcomes data are good and people can actually get it, this could change the trajectory for a lot of families. Mine included. merck.com/product/usa/pi…

@HillaryLinMD When does the YouTube video drop 😉

@MohammedAlo Can I eat the #SugarDiet and bulk with a calorie deficit 🤔

Does sugar increase or cause inflammation? Does a keto or Carnivore diet reduce inflammation? Sugar does not cause inflammation. Ketogenic diets increase inflammation! #keto #sugar #diet #Carnivore #sugarcrash #processedsugar #greenscreen #CardioTwitter #MedTwitter

@MohammedAlo So, should I or should I not give up my Ribeye 🥩❓ I've got to know 😡

Ketogenic keto diet increases and causes Inflammation? Does the keto diet reduce inflammation? #ketodiet #Carnivore #keto #foodscience #science #inflammation #inflammationrelief #antiinflammatory #greenscreen #CardioTwitter #MedTwitter

@drgabriellelyon Plant 🌿Based Sunscreen ‼️Who would have thought 😐

Can you eat your sunscreen? Maybe. There's a compound in your pantry that can change your skin's response to light. That is pasta sauce. A ten-week trial fed participants two and a half tablespoons of tomato paste with olive oil daily. The result was 40 percent less UV-induced skin redness than in the control group, and a second trial found it reduced UV-induced DNA damage. The mechanism is based on the compound lycopene, the pigment that gives tomatoes their red color. It builds up in the bloodstream and acts as an antioxidant in skin tissue, neutralizing the free radicals generated by UV light. It takes at least ten weeks of consistent intake for protection to accumulate. Better DoorDash some Ragu. Note: This does not replace sunscreen. But what I find interesting is the relationship between our diet and the environment. One could potentially eat a "sun-protective" diet.

@ShervinShares Can hold it on camera for 30 seconds with one hand 🫤

NEW Withings BodyScan 2 #withings #withingsbodyscan2 #smartscale

@BradStanfieldMD Well, that leaves Brenzavvy (R) 🫤

The bottom line: Exercise remains the single best intervention for preserving function in older adults. Full stop. I've always advocated that Rapamycin should NOT be used outside of FDA-approved indications and clinical trials Paper: onlinelibrary.wiley.com/doi/10.1002/jc…

Our Rapamycin & Exercise clinical trial has just been published! The topline result? Rapamycin didn't help. Instead, it may have made things worse. Here's what we found 🧵 onlinelibrary.wiley.com/doi/epdf/10.10…

@foundmyfitness 😱

"Off-label" use of testosterone therapy was associated with a 51% greater relative risk of major cardiovascular events. Among 227, 108 men using it, those without documented low testosterone also had higher mortality and more heart attacks, strokes, and heart failure over 10 years. Observational, not causal. And it does not contradict randomized evidence such as TRAVERSE (which I've spoken about before) in properly diagnosed hypogonadism, where testosterone therapy showed no increase in cardiovascular events vs. placebo. But it does caution against liberal use of TRT.

@louisanicola_ Should I hire a trainer 🏋️‍♀️

After age 30, adults can lose 3–8% of muscle mass per decade if they remain inactive. The goal of strength training isn't to look younger. It's to stay capable longer.

Has @TheAlanAragon ever heard of the #RandleCycle 🤨 The Randle cycle (also called the glucose-fatty acid cycle) is a metabolic regulatory mechanism discovered by Philip Randle in the 1960s. Short explanation: When fatty acids are abundant (e.g., during fasting or high-fat intake), they are preferentially oxidized for energy in tissues like skeletal muscle and the heart. This inhibits glucose uptake and oxidation through several mechanisms: •Fatty acid oxidation increases acetyl-CoA and citrate, which inhibit key enzymes in glycolysis (pyruvate dehydrogenase) and glucose breakdown. •It reduces insulin-stimulated glucose transport into cells. •As a result, the body spares glucose (saving it for the brain) and shifts to burning fat. Conversely, high glucose availability can suppress fatty acid oxidation. Why it matters: It explains fuel selection between carbs and fats, plays a role in insulin resistance (chronic fatty acid elevation can impair glucose metabolism), and is relevant to conditions like type 2 diabetes, obesity, and endurance exercise. In athletes like marathon runners, understanding it helps optimize fueling strategies (e.g., fat adaptation vs. carb loading). It’s a classic example of reciprocal regulation in metabolism.

How to manage sugar cravings: "The working recommendation is to try to limit added sugars to 10% of total calories." "Protein powder satisfies the heck out of my sweet tooth." "I took a teaspoon of glutamine and put it in half and half or cream and took a shot of that twice a day and it would kill my sugar cravings." "Protein powders are just such a breakthrough because they satisfy the protein requirements and they take care of essentially having something that is the experience of a dessert." @TheAlanAragon on @hubermanlab

@HLPClips 😎

Minimum amount of resistance training per week to stay healthy: "If you could give me 45 minutes twice a week, that's all you need to do." "If you took 8 to 10 exercises that covered your whole body and you did it twice a week, that would be enough for the average person." "All out, like the devil's chasing you for 20 seconds... the third one, I've never met anybody that wants to do one after because literally you can't breathe." "They compared that to 45 minutes of steady cardio on a treadmill and the results are more or less the same." "You change your life literally with that and a good diet. The whole time thing excuses, it's not relevant." @Dorian_Yates on @hubermanlab