DIRECT project

102 posts

DIRECT project

@DIRECTdiabetes

DIRECT is a European research project looking at type 2 diabetes. It is funded by IMI-JU

Katılım Aralık 2013

64 Takip Edilen148 Takipçiler

DIRECT project retweetledi

Adem yesuf@Ademyesuf·6 Eki

Findings supported by eQTL and in-vitro functional studies and clinically actionable drug-drug-gene interactions with statins. @DIRECTdiabetes @MetGen @UoDMedicine @ezpearson @KsMoneeza @UoDOpenResearch #type2diabetes #pharmacogenomics #PrecisionMedicine

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DIRECT project@DIRECTdiabetes·29 Haz

Visit our new website directdiabetes.org - We will continue to report about the results emerging from our exciting project #diabetes #T2D @IMI_JU #legacy

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DIRECT project@DIRECTdiabetes·18 Ara

Morgan Obura and Femke Rutters report about a @DIRECTdiabetes #MMTT study on “Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes” dx.plos.org/10.1371/journa… @PLOSONE @amsterdamumc @IMI_JU

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DIRECT project@DIRECTdiabetes·17 Ara

Great work by @RobBizzotto et al deciphering how longitudinal data from @DIRECTdiabetes contributes to the understanding of the factors underlying #type2diabetes progression and processes that might be targets for #PrecisionMedicine in #diabetes: doi.org/10.2337/dc20-1… @IMI_JU

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DIRECT project@DIRECTdiabetes·2 Ara

Clusters of co-expressed genes from the blood #transcriptome provide a comprehensive view of #metabolic traits and #T2D - Congratulations to @valborgg @TheBrunakLab and everyone @DIRECTdiabetes #multiomics #type2diabetes @GenomeMedicine

Valborg Gudmundsdottir@valborgg

Glad to see our paper on whole blood co-expression modules in @DIRECTdiabetes cohorts published in @GenomeMedicine! We map out, among other things, co-expression module associations with a wide range of clinical traits, T2D, omics and genetics. rdcu.be/cbzHV

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DIRECT project@DIRECTdiabetes·14 Kas

A wonderful contribution of our consortium and investigators Paul Franks, Jurek Adamski and Olaf Pedersen to the work lead by ⁦@segal_eran⁩ on A reference map of potential determinants for the human serum #metabolome | ⁦@nature⁩ nature.com/articles/s4158…

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DIRECT project retweetledi

Harshal Deshmukh MRCP MPH PhD CCT FRACP@harshaldeshmukh·19 Eyl

Our paper in JCEM. GIPR looks like a interesting drug target for type 2 diabetes. @DIRECTdiabetes study. academic.oup.com/jcem/advance-a…

Harshal Deshmukh MRCP MPH PhD CCT FRACP tweet media

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DIRECT project@DIRECTdiabetes·11 Eyl

Congratulations to @DIRECTdiabetes investigators @dermitzakis @anavinuela and the whole #GTEx consortium on these achievements

Manolis Dermitzakis@dermitzakis

Amazing work by @tuuliel and the colleagues! Honored to be part of this amazing consortium!

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DIRECT project retweetledi

Mark McCarthy@markmccarthyoxf·28 Ağu

@DanielJDrucker @jochwenk @ksuhre High throughput experimental & computat/l approaches do not replace the value of detailed dissection of biological & pathophysiological mechanisms, nor the opportunity for serendipity. Used wisely, they augment & empower such efforts, as well as providing entirely new hypotheses

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DIRECT project retweetledi

Jochen Schwenk@jochwenk·28 Ağu

We provide insights into procedures, challenges, considerations and opportunities when combing #genetics and #proteomics for more informed, large scale studies of the circulating #proteome . #biobanks #olink #somalogic #massspec #affinityproteomics #epitopes #causality

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DIRECT project@DIRECTdiabetes·29 Ağu

A new review is out in @NatureRevGenet by DIRECT investigators @markmccarthyoxf and @jochwenk together with @ksuhre on genetics meeting proteomics.

Mark McCarthy@markmccarthyoxf

I learned a lot writing this review with @jochwenk and @ksuhre. Hope you'll find something to interest in this tour of the interface between plasma proteomics and human genetics! nature.com/articles/s4157…

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DIRECT project retweetledi

Mark McCarthy@markmccarthyoxf·28 Ağu

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DIRECT project retweetledi

Metabolic Imaging@ImagingFat·4 Ağu

Very happy to see our latest publication from @DIRECTdiabetes online today. Congratulations to Rebeca Eriksen and @gfrost59 for leading this work: Dietary metabolite profiling brings new insight into the relationship ... sciencedirect.com/science/articl…

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DIRECT project@DIRECTdiabetes·15 Şub

Already curious about the next @DIRECTdiabetes study? @paulwfranks and team reports in a #preprint on “Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study” medrxiv.org/content/10.110…

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DIRECT project@DIRECTdiabetes·4 Şub

Another fine study lead by @RobertKoivula and @paulwfranks for our consortium got published! Congratulations and thanks to everyone for making this possible!

Diabetologia@DiabetologiaJnl

Twin-cycle hypothesis structural equation models fitted on @IMI_JU @DIRECTdiabetes cohorts support liver fat cycle and show #InsulinSensitivity and #LiverFat mediate association of #PhysicalActivity with glycaemic control @DiabetesLUDC @OCDEM bit.ly/2UkNOh9 🔓

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DIRECT project retweetledi

Innovative Health Initiative@IHIEurope·14 Kas

What happens when patients are newly-diagnosed with type 2 #diabetes? Prof Ewan Pearson, a co-lead of our diabetes project @DIRECTdiabetes, explains. #WorldDiabetesDay2019 #DiabetesAwarenessMonth #IMICarryTheTorch @ezpearson @dundeeuni

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DIRECT project@DIRECTdiabetes·24 Eki

Exciting progress presented from the analysts working on all the different parts of DIRECT #Diabetes in beautiful #Leiden. #dataintegration #multiomics #treatment #stratification

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DIRECT project retweetledi

Ewan Pearson@ezpearson·27 Ağu

Are you a clinician interested in precision medicine? We have two clinical senior lecturer positions. Any specialty. Focus on health data science, genomics or experimental medicine. @UoDMedicine jobs.dundee.ac.uk/fe/tpl_uod01.a…

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DIRECT project retweetledi

Constantinos Parisinos PhD, MRCP@cparisinos·16 Tem

Final vrsn of our MRI liver iron GWAS in @uk_biobank @DIRECTdiabetes online & #openaccess @JHepatology; Great collab @wellcometrust @uclnews @UCL_IHI @HDR_UK @LiverMultiScan @RCOptimalHealth @UniofExeter @YaghootkarH @profhhemingway @easlnews @RajivJalan1 sciencedirect.com/science/articl…

Constantinos Parisinos PhD, MRCP tweet media

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DIRECT project retweetledi

Jochen Schwenk@jochwenk·17 Nis

Great work @RobertKoivula and @paulwfranks for putting this together for @DIRECTdiabetes twitter.com/biorxivpreprin…

bioRxiv@biorxivpreprint

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium biorxiv.org/cgi/content/sh… #bioRxiv

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Keşfet

@METGEN @UoDMedicine @ezpearson @KsMoneeza @UoDOpenResearch @PLOSONE @amsterdamumc @RobBizzotto