Valborg Gudmundsdottir

The impact of low-frequency genetic variants on serum protein levels biorxiv.org/content/10.648… #biorxiv_genomic

Excited to share our new preprint on the long-term temporal stability of circulating proteins! We describe the biological characteristics of temporally stable vs variable proteins, as well as the effects of genetic factors and disease state: lnkd.in/dVZXTg8x

See also our Research Briefing in Nature Aging: rdcu.be/dUOa2 and Alzforum story: alzforum.org/news/research-…

We believe that further study of these proteins may add to the understanding of the early disease processes and inform both therapeutic and biomarker research in Alzheimer’s disease.

Our recent paper in Nature Aging describes the serum proteomic signature preceding Alzheimer‘s disease diagnosis, identifying over 300 proteins that we describe with regard to their relationship to the APOE-e4 risk genotype. nature.com/articles/s4358…

High-throughput proteomics (>4,000 proteins) assessed in more than 5,000 older adults to unravel biomarkers and biology of Alzheimer's disease, in APOE-ε4 and non-APOE-ε4 individuals nature.com/articles/s4358… @NatureAging @eliafrick LOAD=late-onset Alzheimer's

And very excited to finish this Alzheimer's disease proteomics paper in the new year with Elísabet in our group! Great collaboration with Emory and ACE. Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease medrxiv.org/content/10.110…

Also great to be a part of this heart failure study from AGES and replicated in CHS - Proteomic prediction of incident heart failure and its main subtypes onlinelibrary.wiley.com/doi/abs/10.100…

Also thanks to our collaborators in CHS for participating in this project!

Glad to finish the year with the publication of our atrial fibrillation proteome paper, great work by Þórarinn and Anna Eva, and my first last author paper! academic.oup.com/europace/artic…

Finding the genetic basis of protein expression can reveal genetic mechanisms of disease. Here @valborgg et al. link low-frequency & common DNA variants to thousands of serum proteins, finding genetic overlap between circulating proteins & various diseases go.nature.com/3u1UEKp

Our GWAS of 4782 serum protein measurements in 5368 Icelanders is out!

Finally, for many phenotypes we find an enrichment of direct associations with serum proteins regulated by established GWAS loci for the same phenotype. 5/5

We perform a systematic colocalization analysis between serum pQTLs and 81 GWAS traits, finding that 27% of protein-associated loci colocalize with at least one GWAS phenotype and 51% of all proteins with a study-wide significant pQTL. 4/5

Happy to share our latest preprint, a full GWAS of 4782 serum protein measurements in 5368 individuals from the AGES-Reykjavik cohort. biorxiv.org/content/10.110… 1/5

Postdoc position in computational biology available at the Icelandic Heart Association! hjarta.is/postdoc/

Glad to see our paper on whole blood co-expression modules in @DIRECTdiabetes cohorts published in @GenomeMedicine! We map out, among other things, co-expression module associations with a wide range of clinical traits, T2D, omics and genetics. rdcu.be/cbzHV