DMM Journal

Join researchers working on #PediatricCancer at our Meeting this October at Nationwide Children’s Hospital, USA. Organisers: James Amatruda, Pratiti (Mimi) Bandopadhayay, Ana Banito & Elaine Mardis Register at bit.ly/3OCi1q9 Early-bird deadline: 19 June 2026

Timothy Phoenix @timphoenixUC is speaking on 'Modeling CNS tumors to advanced basic and translational discoveries' at our Journal Meeting this October #DMM2026cancer #pediatriccancer #cancer Register to attend: biologists.com/meetings/dmm20… Early-bird deadline: 19 June 2026

In our April Patient Voice feature, we spoke with Liz and Jay Scott about Alex’s Lemonade Stand Foundation—their mission, the collaborative efforts between physicians, researchers, families, and patient advocates, and their vision for the future. doi.org/10.1242/dmm.05…

Mimi Bandopadhayay is speaking on 'Anti-transformation screens identify mediators of oncogenic transformation as novel therapeutic targets for pediatric brain tumors' at our Journal Meeting #cancer Register to attend: biologists.com/meetings/dmm20… Early-bird deadline: 19 June 2026

Weekend read: head to @preLights website and read a preprint about Sun2 role in mechanosensing-driven extracellular matrix production and lung fibrosis, chosen by Beth Chopak. Prelight: bit.ly/4ucTbgj Preprint: doi.org/10.64898/2026.…

For anyone with an interest in (embryonic) stem cells, developmental biology and neuroscience. A short short for you...

Progressive myoclonus epilepsy type 1 involves upregulated immune‑response genes, reduced oxidative phosphorylation and disrupted lysosomal function (with lysosomal genes activated and those required for acidification suppressed). Malyutina, Joensuu & co doi.org/10.1242/dmm.05…

Night owl or morning lark — it’s more than hearsay. In our April Issue Review, Siyu Chen and David Ray outline the evidence linking circadian rhythms to chronic inflammatory diseases and explore how this connection could be leveraged to improve treatment. doi.org/10.1242/dmm.05…

To mark #BrainTumorAwarenessMonth, we share our subject collection featuring research to accelerate translation into therapeutics tinyurl.com/4xjczsp8. Why not join us at our 'Innovative ‘Preclinical Models for Pediatric Cancer Research’ meeting tinyurl.com/yc2jra4k

Delilah Hendriks @HendriksDelilah is speaking on 'Advanced human organoid models to unravel early events of tumorigenesis' at our Journal Meeting this October #DMM2026cancer Register to attend: biologists.com/meetings/dmm20… Early-bird deadline: 19 June 2026

@koslofflab Don't miss the interview with the first author, Anna Fassler Bakhman. '... I volunteered ... as a first-aid ambulance responder, where I encountered a wide range of medical situations and saw how biological processes directly affect people's lives.' doi.org/10.1242/dmm.05…

Researchers mapped 77 positions linked to Hirschsprung’s disease or multiple endocrine neoplasia type 2 and predicted how mutations across all 594 extracellular residues might alter RET structure. Fassler Bakhman, @koslofflab & co doi.org/10.1242/dmm.05…

Join us for the Developmental Origins of Paediatric Cancer Symposium 📢 📅 8 June ⏳ Sign up by 22 May 🩵 Kindly supported by @Co_Biologists, @NeuroblastomaUK and @ParseBio. View the programme and register at bit.ly/4uMPDl0

With new regulations taking effect, the question of which models best capture human disease is becoming urgent. In our Editorial, we discuss why in vivo models remain essential, and our editors outline what in vitro systems can and cannot achieve. doi.org/10.1242/dmm.05…

Michael Underhill is speaking on 'Modelling synovial sarcoma in the mouse – insights into a potential cell of origin and tumorigenic trajectories' at our Journal Meeting this October #DMM2026cancer Register to attend: biologists.com/meetings/dmm20… Early-bird deadline: 19 June 2026

Head to @prelights website and read a preprint about changes in gut microbiome over the course of multiple sclerosis, chosen by Carole Djagang, Nour HAROUN, Phalica Georges and uMontreal Neuro preLighters. Prelight: bit.ly/4tFP63g Preprint: doi.org/10.64898/2026.…

Ana Banito is speaking on 'Somatic gene delivery for flexible in vivo modeling of pediatric sarcoma' at our Journal Meeting this October #DMM2026cancer Register to attend: biologists.com/meetings/dmm20… Early-bird deadline: 19 June 2026

DMM congratulates Francesca Giulia Urso (centre), from @reNEW_Global, winner of the DMM-sponsored poster prize at the latest advances in Latest Advances in Stem Cell-Based Disease Modelling and Drug Screening symposium.

The program for our @cclguk symposium, co-sponsored by @DMM_Journal, @NeuroblastomaUK and @ParseBio , on the developmental origins of paediatric cancer is now finalised (8th June, @TheCrick): cclg.org.uk/information-pr…

Bone‑marrow biopsies from severe aplastic anaemia patients showed increased nestin⁺ niches, supporting immune injury and maladaptive stromal remodelling as disease drivers and the importance of the marrow microenvironment. Beerlage, Drexler, Tzankov & co doi.org/10.1242/dmm.05…