preLights

🚨 Call for preLighters!🚨 Help us highlight the most exciting biological preprints. Share your insights, build your profile, and be part of a supportive community! 🌍 Interested? Apply today & help shape the future of science publishing! 📢 More info: prelights.biologists.com/news/join-the-…

1/ Annbatch unlocks terabyte-scale training of biological data in anndata 🚀 Check out our preprint here: arxiv.org/abs/2604.01949 📄 Grab the code on GitHub: github.com/scverse/annbat… Massive shoutout to project leads @felix_f0097 and Ilan Gold for driving this home! 🧵👇

Detection of metastatic burden in mouse models should be done in 3D and at single-cell resolution. The solution is CODA, a workflow that maps organs, tumors and mets exhaustively, in 3D, and at single-cell resolution. Read about this here: biorxiv.org/content/10.648…

🚨 New preprint alert! 🚨 A study 6 years in the making, made possible by funding from @SimonsFdn: "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" up on #biorXiv biorxiv.org/content/10.648… a 🧵 1/11

Catch up on Development presents… webinar on neural development Our February webinar featured early-career researchers studying neural development. Here, we share the talks from Joaquín Navajas Acedo and Carlo Donato Caiaffa. #DevPres thenode.biologists.com/catch-up-on-de…

プレプリントをbioRxivに公開しました． 細胞レベルの利き手から多細胞レベルの利き手が決まる物理メカニズムの一端を実験と理論の組み合わせから明らかにしました． Force transmission balance through adhesions determines multicellular handedness doi.org/10.64898/2026.…

2️⃣ DcpS undergoes amyloid aggregation and liquid–liquid phase separation under specific conditions. Disease-associated mutants show enhanced aggregation, supporting a role in initiating or worsening proteinopathies. #preprint #preLight by Joao Gabriel ⬇️👀 prelights.biologists.com/highlights/liq…

Another two preLights resulting from the preprint review initiative led by @maroliufrj #UFRJ 1️⃣Exploring and characterising the peptide QBP1 as a promising inhibitor of amyloid aggregation in proteins linked to type 2 diabetes. #preLight by Joao Gabriel ⬇️ prelights.biologists.com/highlights/a-p…

Shining light on a dark metabolite: 4,5-DHHA as a potential #biomarker for mitochondrial disease with respiratory chain dysfunction. 🔦 New post by Hannah Pletcher on work from Owen S. Skinner & colleagues #mitochondria #biochemistry #preLight ⬇️👀 prelights.biologists.com/highlights/45-…

Our preprint list highlighting new tools and techniques in imaging is now up on FocalPlane. Check it out, and let us know if we are missing any research that we should add to the list. focalplane.biologists.com/2026/04/03/mic…

Protein synthesis is not equally accurate across organs. Excited to share our new preprint: biorxiv.org/content/10.648… We developed a new mouse model to quantitatively monitor translation errors and uncovered the spatiotemporal dynamics of the “quality” of protein synthesis.

Attachment of ADP-ribose molecules to RNA Polymerase II allows its traffic regulation on transcribed genes in response to oxidative DNA damage 🧬 Insightful #preLight by Élise & @CaronPierre13 on preprinted work from @GregersenLab ⬇️👀 prelights.biologists.com/highlights/oxi…

New preprint with Garnett lab 🚀: from descriptive → causal single-cell atlases in CRC.We build the largest CRC atlas (>300 pts, 1.5M cells) using continual learning, and link cell states to causal drivers via Tahoe-100M, validated in organoids! biorxiv.org/content/10.648…

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. biorxiv.org/content/10.648… 1/

We might be close to obliterating poliovirus, but non-polio enteroviruses are on the horizon. @Sergiu_P_Pasca & team use a human assembloid model to show how poliovirus, EV‑A71 & EV‑D68 each disrupt neuromuscular function in different ways. #preLight ⬇️👀 prelights.biologists.com/highlights/hum…

Using #SingleMolecule imaging we find that TFs: -boost co-transcriptional #ribosomal #RNA processing! -their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)! @biorxivpreprint Anastasiia Chaban @embl biorxiv.org/content/10.648…

New #preprint 😍‼️ led by 2 incredible postdocs Ni Zhan & @ranjithbio: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing biorxiv.org/content/10.648… A short 🧵

🧵1/ Excited to share our new preprint! We uncover a new layer of control in how cells restart transcription after mitosis. 👉 TTF2 prevents premature rRNA transcription during mitotic exit (biorxiv.org/content/10.648…)

Let me announce the other preprint uploaded last week: “Flow-driven lumen remodeling and valve opening in the vas deferens” biorxiv.org/content/10.648… This work tackles a fundamental question: how does a reproductive duct dynamically control its lumen shape during sperm transport?

We’re excited to share our new bioRxiv preprint: “Transient contractility attenuation reprograms epithelial cells into a protrusion-driven state that drives tissue fluidization” biorxiv.org/content/10.648… This work asks a simple but deep question: How do tissues actively fluidize?

Deadline is 30 March to apply to join the @Dev_journal Preprint Editor team