Wesley Wierson
965 posts
@DNA4CY
Genome hacker 🧬 | Techno-optimist 🚀 | Iowa State alumni 🌪 | Tattoo collector 💉 | Building @LEAHLabsInc 🐶, LifEngine 🚂, @UViiVE ☀️, VelociTx 🏎️
We're excited to announce that @ButterDev_ is joining Modal to help us continue to build the best sandbox infrastructure. Welcome to the team! 💚🧈
Finding Zevo - and Uvy, and Atlas, and Buster... At UViiVE, we are rocketing bits to bioactives (and more) at the speed of agentic AI teams. We are so excited to share the first chapter of our story, where we worked alongside our custom AI Scientist agents to build our fleet. Read more about the key underlying technology at our Medrxiv preprint to address the industry’s primary hurdle with agents and LLMs at large - the "trust gap." As a result, UViiVE now outperforms OpenAI, Claude, and Grok in hallucination detection and all measured benchmarks, delivering truly trusted and verifiable scientific output. While there are a thousand ways to solve a problem, our architecture currently stands alone in its reliability and is continuously improving. It was a real pleasure working with our fleet and Dr Ankit Sabharwal @ankitsabharwal9 for our first challenge to make a dent on Rare Disease at Dell Medical School. Cheers to the awesome human team - @militspatel , Dr Anna Carrano, Dr Maarten Rotman, and @DNA4CY . @Uviive
This is totally out of control: There’s 0 - I repeat 0 - evidence any of the LLM work did anything meaningful for Rosie’s cancer I’m sorry to rain on the parade here. I know we want to believe. But, it’s possible to do a lot of things and have nothing happen @paul_conyngham co-administered α-PD-1 (conventional immunotherapy) with a TKI and the mRNA. It’s probably the most effective cancer immunotherapy of all time. This isn’t a small detail! There’s no evidence his process (beyond FDA approved doggie α-PD-1) had any impact on disease progression. The most parsimonious explanation is a partial response to α-PD-1 I get it. The chat bots make for a great story (although checking multiple LLMs isn’t validation), but it’s really just a neat story. It’s fundraising copy. Before he starts selling the “custom neoantigen mRNA vax” story to consumers, he should provide some evidence it did anything! That’s responsible citizen science This is just storytelling for the AGI true believers. Specifically, a story in search of venture money
Just installed this and ran a test on overcoming NK cell exhaustion in solid tumors. Multiple failures happened. Most critically, the final report has 25% citation contamination (110 out of 452 citations). We have an agent fleet with learned behavior to catch citation hallucinations at extremely high fidelity (writing a paper on this right now). My agent tells me this happened at Stage 3-4 keyword searches scraping papers containing the words “solid” or “cell” from entirely unrelated fields. Got some good papers on “Roman Galactic Plane Survey” and “Pulsatile Therapy for Perovskite Solar Cells” though! Happy to share the data if helpful.
THIS is the wildest open-source project I’ve seen this month. We were all hyped about @karpathy's autoresearch project automating the experiment loop a few weeks ago. (ICYMI → github.com/karpathy/autor…) But a bunch of folks just took it ten steps further and automated the entire scientific method end-to-end. It's called AutoResearchClaw, and it's fully open-source. You pass it a single CLI command with a raw idea, and it completely takes over 🤯 The 23-stage loop they designed is insane: ✦ First, it handles the literature review. - It searches arXiv and Semantic Scholar for real papers - Cross-references them against DataCite and CrossRef. - No fake papers make it through. ✦ Second, it runs the sandbox. - It generates the code from scratch. - If the code breaks, it self-heals. - You don't have to step in. ✦ Finally, it writes the paper. - It structures 5,000+ words into Introduction, Related Work, Method, and Experiments. - Formats the math, generates the comparison charts, - Then wraps the whole thing in official ICML or ICLR LaTeX templates. You can set it to pause for human approval, or you can just pass the --auto-approve flag and walk away. What it spits out at the end: → Full academic paper draft → Conference-grade .tex files → Verified, hallucination-free citations → All experiment scripts and sandbox results This is what autonomous AI agents actually look like in 2026. Free and open-source. Link to repo in 🧵 ↓
The results are finally in! 🏆💻🧬 I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵
I am very excited about AI, but to go off-script for a minute: I built an app with Codex last week. It was very fun. Then I started asking it for ideas for new features and at least a couple of them were better than I was thinking of. I felt a little useless and it was sad.
We just raised $60 million for Blueprint. To bring my longevity protocol to you. Our society has made us unwell…metabolically, mentally, spiritually. We’re addicted. Social media, porn, nicotine, junk food, fast food, smartphones, streaming, energy drinks, and gambling. Each perfectly engineered to keep us in their grip. Years ago, I was owned by these systems. They wrecked me, and my health. I wish there had been someone in my life helping me break free. Blueprint will be that system. Collectively, we will claw our power back. Blueprint will take better care of people than they can themselves. Better than the healthcare system does. Better than our societal norms allow. We will be your home for health. Blueprint will help you feel clear-headed and vibrant. You will become more jacked and beautiful with our presence in your life. There’s nothing better than feeling your best. Some of the world’s most powerful people are backing Blueprint. Talent are pivoting their careers to join our team. They rightly see that Blueprint is in the right place, at the right time, for the global emergence of the new macro trend of health, anti-aging and Don’t Die. In this post I’ll cover: + Who’s investing + What Blueprint will be + Who’s joining + Open positions + How to get early access The next era of human is here. [WHO’S INVESTING] This remarkable group of people are Blueprint investors. They are backing the next great frontier: human longevity. + Akshay Bd + Alex Hormozi + Amanda Cassatt + Andrej Karpathy + Ari Emanuel + Balaji Srinivasan + Bill Lee + Brad Keywell + Brian & Veronica Grazer + Bryan Meehan + Cameron Winklevoss + Carter Reum + Chris Hollod + Dan Manges + Dave Morin + Don Wilson + Drew Houston + Emmett Shear + Eric Demuth + Fareed Adib + Generational Family Office + Jason Fried + Jay Shetty + Joe Gebbia + Joe Lonsdale + John Carmack + Joshua Kushner + Kamal Ravikant + Karim Beguir + Kevin Hartz + Kim Kardashian + Kyle Widrick + Logan Paul + Michael Cao + Michael Kives + Naval Ravikant + NIV + Olaf Carlson-Wee + Paris Hilton + Pippa Lamb + Saquon Barkley + Ken Katz + Seth Bannon + Shayne Coplan + Steve Aoki + Steven Bartlett + Suna Said + Tyler Winklevoss + Winnie Liu + Wojciech Zaremba [TEAM] Defeating death would be humanity’s greatest accomplishment. Big things are happening right now in our small corner of the galaxy. We see the consequence of this moment and are working to positively influence the future of intelligent existence. We believe that product is philosophy and companies can influence the world. Join if you love to work insanely hard and also get eight hours of sleep. Joining our team as CEO is Gyre Renwick. He was previously President of Modern Health and before that an executive at Google Health and Lyft Healthcare. Gyre builds complex health systems into growth engines. In this next chapter, I am doubling down on Blueprint and Don’t Die. I’m all in. Gyre will run the business and I will focus on vision, strategy, and birthing Don’t Die into the world. Blueprint is the practical manifestation of Don’t Die. They are the same thing. I will continue to juggle many full-time jobs: rejuvenation athlete, Blueprint vision, leading the Don’t Die moral philosophy and ideology, building a global community, and content creation. Ultimately, both Blueprint & Don’t Die ladder up to the same thing, answering the question: ‘what does humanity do as we give birth to super intelligence?’. Kate Tolo (co-founder), Gyre, and I will be in lockstep building this mission together. Roles we are filling now: + Chief Technology Officer + Chief Product Officer + Chief Medical Officer + Chief Marketing Officer + Engineers of all types + See all open roles Refer your most talented friends. If you don’t see a job fit, still email us. [BLUEPRINT VISION] We’re making my protocol accessible to everyone. To replicate everything including the measurements, protocols, therapies - and make it easy and accessible for others to do in a community. For your family and friends to do this too. Many think that the world’s most powerful people have their health figured out. The truth is, most everyone is floundering. Luxury concierge services often do little for wealthy people as the biggest gains are not in expensive therapies but daily habits. We will help you build life foundations, starting with the basics and graduating to advanced therapies. Our goal is to be more effective in helping you achieve your health goals than any health system or concierge in the world. Blueprint will build around: + your preferences + your budget + your preexisting conditions + your prior results + your prescriptions + your level of effort It’s health within context. I built Blueprint to solve my own problem. My body and mind were broken, and I didn’t know who to trust to help me fix it. Everyone disagreed with everyone else. I found sanity in gathering a team of doctors and building a protocol based upon robust measurement and scientific evidence. It’s a methodical process that produces better outcomes and results in fewer mistakes and wasted time. After my team and I built a protocol for me, my friends and family asked if they could get access too. Then their friends and family asked and I said yes again. The circle kept on expanding until we stumbled into Blueprint becoming a company. We will tell you to do less. Most good health can be achieved with very little effort. It’s the systems, infrastructure, knowledge, and piecing through the noise that is hard. Blueprint is Bryan Johnson’s protocol, for everyone. What this will practically mean: + Blood draws + Food delivery + GLP-1s + Rx prescriptions + Free protocols + Toxin testing + At-home tests + Skin care & hair care + Nutrition & supplementation + Advanced therapies And your AI health companion will make it simple. I like to call this my Autonomous Self. In the same way you put in an address and digital navigation tells you the best way to get there, Blueprint is navigation to vibrance. Our goal is to remove the thinking and hassle for you so that you can focus on building durable life habits and achieve the best health of your life. I love thinking about what the future will say about us. When I think from the perspective of those who exist in the year 2500, I think they’ll observe that the 2020s and 2030s was the time when humans figured out that they were the first generation who wouldn’t die. Early access below. What an amazing opportunity. Let’s do this together. Bryan
