Daniel Strebinger

Retrotransposons are cool - but harnessing them for kilobase insertions AND seeing their molecular structure is even more exciting. Great work led by @GraceKC Check it out!!

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

Exciting work from @KalliKappel - using pooled optical screening to determine sequence features that contribute to condensate formation! If interested in this topic reach out to Kalli, who just started her lab at UCLA. She is an amazingly insightful scientist and a great person!

Introducing CondenSeq, an imaging-based high-throughput approach for characterizing protein condensates within the nuclear environment. @KalliKappel nature.com/articles/s4159…

We're hiring! Our lab at the Ragon Institute of MGB, MIT, and Harvard is looking for a motivated postdoc with experience in developing and applying deep learning models. You'll work at the intersection of spatial transcriptomics and structural biology. #postdoc

1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! bit.ly/redicas9

Help is on the way! Ready to take stem cell technologies to the next level for drug development @CReM_Boston @GSK: Global Biopharma Giant GSK and BU/BMC Announce Collaboration to Pioneer New Lung Disease Treatments bu.edu/articles/2024/… @BUPulmonary @The_BMC @BUMedicine

Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting (Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)

So excited to announce that the Kappel Lab will open at @UCLA @uclachem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here: sites.google.com/view/kappellab/

RT @SGRodriques: Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist. Read our b…

@thestrecker @durocher1 @zhangf @MGHMolBio Well deserved Prof. Strecker!! So happy for you! Looking forward to the amazing discoveries and tools to come!

Excited to announce the opening of the Strecker lab at MGH Molecular Biology/CCIB and HMS Genetics. I am tremendously grateful to all of my labmates who have helped me over the years, my past mentors @durocher1 and @zhangf, and my new colleagues @MGHMolBio for the opportunity!

We are hiring at all levels, please share, and reach out if you are interested in our work! (thestreckerlab.org)

We are excited that DIRECTED will enable delivery to cell types that are difficult to target for therapeutics. Future developments will unlock the full potential of cell-type-specific enveloped delivery! All constructs will be on Addgene shortly. 7/7

DIRECTED is compatible with delivering many cargo types, including proteins and RNPs (e.g. Cas9-sgRNA). We show that DIRECTED allows the specific transduction of T cells or B cells in PBMCs, which are a complex mixture of different cell types, and even works in whole blood. 6/7

Excited to share DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design): a programmable platform for cell-type-specific delivery. rb.gy/c3rdw Thank you to @FrangiehChris, @mircoscopy, @GuilhemFaure, Rhiannon Macrae, @zhangf 1/7