David Yang

Excited to share our work on immune microenvironmental features in prostate cancer!

Deeply grateful to my coauthors, the patients and loved ones who made this work possible, and @PCFnews for supporting this study 7/n

Together, our findings nominate immune spatial clustering as a potential biomarker of clinically meaningful immune enrichment in high-grade localized prostate cancer 6/n

These immune clusters were also associated with molecular features suggestive of a T cell-mediated antitumor response 5/n

We found that immune cell quantity alone was not associated with outcomes. Instead, a higher burden of spatially dense immune clusters was associated with a lower risk of distant metastasis in two independent cohorts 4/n

We leveraged deep learning analysis of H&E images (obtained as part of routine care) to evaluate whether immune features were associated with outcomes after prostatectomy 3/n

Growing evidence suggests that a subset of prostate cancer is immune-enriched, but the clinical consequences of immune enrichment were largely unknown 2/n

@davidjeinstein Absolutely. cT3a by DRE is not the same as pT3a

I’ve been worried about overtx w extending ADT based solely on MRI T3, especially grade 1

@JoYatesResearch Congrats!

🧵 Introducing SpatialFusion: a lightweight #multimodal #FoundationModel for pathway-informed spatial #niche mapping. 📄 doi.org/10.64898/2026.… It combines #histopathology and #SpatialTranscriptomics to identify functional microenvironments in tissue. Here’s what we found 👇

@HugoAerts Really cool stuff. Congrats!!

Big news: the thymus may be critical for adult health What if we missed something fundamental about the immune system? In two back-to-back papers in Nature, we show thymic health (AI on 30,000+ CT scans) links to longevity, disease risk & immunotherapy outcomes.

@VincentWenxinXu @YuWeiChenMD @DrChoueiri @DanaFarber_GU @MDAndersonnews @Clara__Steiner @lilli_ash @ChadTangMD @DrYukselUrun @yekeduz_emre @PavlosMsaouel @EUplatinum Congrats!

@DrChoueiri @DanaFarber_GU @MDAndersonNews @Clara__Steiner @lilli_ash @ChadTangMD @DrYukselUrun @yekeduz_emre KIM-1 and ctDNA (next-generation, genome-wide assay) are complementary in oligometastatic RCC, and the K-COMPASS model identifies patients with best outcomes after metastasis directed therapy. @ChadTangMD @PavlosMsaouel Check it out in @EUplatinum: sciencedirect.com/science/articl…

The KIM-1 story continues with this joint effort between @DanaFarber_GU @VincentWenxinXu and @MDAndersonNews @ChadTang presented the K-COMPASS model, integrating circulating KIM-1 + ctDNA MRD to risk-stratify oligometastatic ccRCC treated with MDT. - KIM-1 and ctDNA independently associated with systemic therapy-free survival (baseline and 3 mo) - Higher KIM-1 tracked with worse outcomes (baseline PFS HR 2.2 / OS HR 5.1; 3-mo PFS HR 3.5 / OS HR 5.0) - Model performance: C-index 0.76; online tool available (trialdesign.org) Promising integrated blood-based + clinical risk model for risk-adapted decisions. Happy to share that the full publication is now available on @EUplatinum: 10.1016/j.eururo.2026.01.004 #GU26 #RCC @OncoAlert

@laurasenamd @Adam_Weiner535 @CR_AACR @PCF_Science @AACR @hopkinskimmel Congrats!

1/11 Excited to share our study of polyamines in prostate cancer in @CR_AACR! We found that, in models of advanced PCa, supraphysiological androgens (SPA) drive production of polyamines that help the cancer survive. @PCF_Science @AACR @hopkinskimmel aacrjournals.org/cancerres/arti…

@mouwlab Congrats!

Congrats Filipe! An incredible honor and so well-deserved!

@JoYatesResearch @VanAllenLab @val_boeva @DanaFarber @CSatETH Congrats!!

@VanAllenLab @val_boeva @DanaFarber @CSatETH We hope this serves as a foundational resource for the EAC & broader cancer research community.🧬 Full paper here: cell.com/cell-reports-m… (9/9)

Thrilled to share our new paper out today in Cell Reports Medicine! @VanAllenLab @val_boeva We map cell states & neighborhoods across clinical stages of esophageal adenocarcinoma (EAC) using single-cell, epigenomic & spatial data.🔗cell.com/cell-reports-m… (1/9)

@sjohri20 @NatureComms @VanAllenLab Congrats!!

🚀Excited to share our new paper, now published in @NatureComms! ✨ We present BEANIE, a nonparametric method that reduces false positives when analyzing differential gene signature expression in multi-patient clinical scRNA-seq cohorts @VanAllenLab 🧪🧵nature.com/articles/s4146…

@SashaGusevPosts Congrats!!

Thrilled to receive the Presidential Early Career Award for Scientists and Engineers (PECASE)! Could not have done this without my amazing lab members and mentors. whitehouse.gov/ostp/news-upda…

@PCFnews @urotoday Thanks for giving @MtkingMD and me the opportunity to speak about our work!

Researchers Drs. Martin King & @DYangMD discuss AI's potential to automate and standardize prostate tumor assessment. Could this revolutionize clinical decision-making in #oncology? Watch the full discussion on @urotoday - bit.ly/4fNC9O7

@DKang_PhD @fredhutch Congrats!!

Off to a new start at @FredHutch as Assistant Professor - I can’t be grateful enough to my incredible mentors/colleagues/friends at DFCI for their support. It’s hard to leave them behind, but I’m looking forward to exploring new opportunities at FH! #ExerciseOncology

Tonight we sit with the cherished memories of a truly unforgettable individual who changed the lives of so many fighting cancer. Tomorrow we stand and get back to the fight against the terrible disease that took one of our best, brightest, and kindest. Love you forever, Felix.