dana_peer

2.2K posts

dana_peer

dana_peer

@dana_peer

Katılım Ağustos 2008
165 Takip Edilen14.8K Takipçiler
dana_peer
dana_peer@dana_peer·
Amazing trailblazing super stars. I am SO lucky to work with them. CONGRATULATIONS!
Memorial Sloan Kettering Cancer Center@MSKCancerCenter

Congratulations to Dr. Adrienne Boire, a neuro-oncologist at Memorial Sloan Kettering Cancer Center (MSK), and Dr. @TuomasTammela, a cancer biologist at MSK, on receiving @AACR Trailblazer Cancer Research Grants, announced during #AACR26. Nine early-stage investigators and six mid-career investigators were awarded grants of $1 million each to support meritorious and promising cancer research. The grants will be distributed over three years. Share a note of kudos to Dr. Boire and Dr. Tammela in the comments below! 👏

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dana_peer
dana_peer@dana_peer·
Great talk by great scientist
Memorial Sloan Kettering Cancer Center@MSKCancerCenter

This morning, MSK physician-scientist shared research during the Opening Plenary Session at #AACR26 about how cancer cells escape targeted therapy by changing identity. @AACR Key conclusions: ➡️ Adenocarcinomas with RB1 loss are at risk ("primed") to undergo NE lineage transition in response to therapelic stress. ➡️ In "primed" tumors, extracellular matrix production by cancer associated fibroblasts restrains NE lineage transition through integrin -> YAP/TEAD activation. Notch pathway activation acts as a second level of restraint. ➡️ This adeno <-> NEPC transition can be toggled in either direction using existing pharmacologic tools, with potential therapeutic implications. ➡️ New vulnerabilities arise once the NE transition is complete, notably on MYC family paralogs with co-option of TIP60/KAT5 as a coactivator.

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Memorial Sloan Kettering Cancer Center
🚨 An experimental, personalized vaccine using #mRNA to prevent #pancreaticcancer from returning after surgery continues to show promise in a small, 16-person patient group. New results from a phase 1 clinical trial, being presented at #AACR26, show that nearly 90% of people whose immune systems responded to the vaccine were still alive six years later. “These early results show this new immunotherapy approach has the potential to be groundbreaking for one of the deadliest cancers,” says MSK physician-scientist Dr. Vinod Balachandran (@TheVinodLab), the trial’s principal investigator and Director of The Olayan Center for Cancer Vaccines. Learn more about these findings: bit.ly/3QuIiaL @AACR
Memorial Sloan Kettering Cancer Center tweet media
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shalev itzkovitz
shalev itzkovitz@SItzkovitz·
Our paper on zonation in the truly healthy human liver is out in @Nature: nature.com/articles/s4158… Acquisition of healthy human tissues for cell atlas studies is challenging. The regenerative capacity of the human liver enabled analysis of tissues from living organ donors.
shalev itzkovitz tweet media
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Memorial Sloan Kettering Cancer Center
New research from MSK, led by Dr. Scott Lowe, Dr. @dana_peer, and colleagues, shows how pancreatic cells can shift from a benign state to cancer — revealing new aspects of this process. The study, published in @CellCellPress, identifies a critical window for early detection and prevention. Learn more: bit.ly/486Vgl5
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Lowe Lab
Lowe Lab@LoweLabMSKCC·
🚨 Just out from our lab in @cellbycellpress - a comprehensive review of cellular senescence, part of the special issue celebrating the Hallmarks of Cancer cell.com/cell/fulltext/… 🚀
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dana_peer
dana_peer@dana_peer·
Looking forward to this!
Memorial Sloan Kettering Cancer Center@MSKCancerCenter

Physicians and scientists from MSK will join oncology experts and members of the global #cancerresearch community to present the latest advances in cancer discovery at @aacr Annual Meeting 2026, taking place April 17–22, in San Diego, California. MSK investigators will share significant new findings and participate in high‑impact sessions spanning cancer metastasis, immuno‑oncology, molecular biology and genetics, early‑phase drug development, tumor evolution, computational oncology, and precision medicine. Learn more: bit.ly/4sM0xpS #AACR26

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AACR
AACR@AACR·
The AACR congratulates James P. Allison, PhD, FAACR, recipient of the 2026 AACR Award for Lifetime Achievement in Cancer Research. He will accept the award and deliver remarks on Sunday, April 19, during #AACR26 in San Diego. brnw.ch/21x1qC2 #AACRFellows @UTMDAnderson
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dana_peer
dana_peer@dana_peer·
2) Here we show that most metastatic clones are highly plastic and once they can metastasize they have the plasticity to adapt to many organs. Each metastatic clone resides in multiple organs and each organ has many evolutionary distinct clones.
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dana_peer
dana_peer@dana_peer·
3) The trick was recasting the problem in mathematical terms, and training an AI model to predict which DNA regions retain memory over time and pinpointing the responsible bps and their code.
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dana_peer
dana_peer@dana_peer·
2) This is a great example of using AI to discover biological mechanism, how memory is encoded in the DNA. We did not to use fancy large models, foundations models failed! Instead a simple interpretable model based off of BPNET could pinpoint the DNA code ->
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