Daniel Milad, M.D.

GPT-5 delivers near‑perfect ophthalmology answers, and the mini‑low mode gives the best accuracy per dollar. The study pits 12 GPT‑5 configurations against o1, o3, and GPT‑4o on 260 closed American Academy of Ophthalmology Basic and Clinical Science Course questions, then checks accuracy and explanation quality. Questions were answered with no examples in the prompt, and each reply had to be a single letter plus a 1‑sentence justification, so grading stayed strict and simple. GPT‑5 exposes a “reasoning effort” control, from low to high, that increases the model’s private thinking tokens before it speaks, the minimal setting underperformed and was dropped. Top result, GPT‑5‑high hit 96.5% accuracy, o3‑high scored 95.8%, o1‑high 92.7%, GPT‑4o 86.5%, while GPT‑5‑nano‑low trailed at 77.3%. Head‑to‑head strength was estimated with a Bradley‑Terry model, which turns pairwise wins into a single “skill” score, GPT‑5‑high was 1.66x stronger than o3‑high and 5.10x stronger than o1‑high on accuracy, and 1.11x stronger than o3‑high on rationale quality. Rationales were graded by an LLM judge that compared each 1‑sentence explanation to the official reference text and picked the closer one, which scales cleanly beyond small human panels. Cost mattered, plotting accuracy against mean cost per question showed a Pareto frontier from GPT‑5‑nano‑low to GPT‑5‑high, and GPT‑5‑mini‑low sat on that frontier as the best low‑cost high‑performance point, meaning nothing else was both cheaper and more accurate. Practical read, GPT‑5‑high fits settings where every point of accuracy matters, GPT‑5‑mini‑low fits budgeted scale, and GPT‑5‑medium tracks close to o3‑high on performance and cost. ---- Paper – arxiv. org/abs/2508.09956 Paper Title: "Performance of GPT-5 Frontier Models in Ophthalmology Question Answering"

GPT-5 (with high reasoning effort) achieves near-perfect accuracy on a high-quality ophthalmology question-answering dataset. Based on these other reports, GPT-5 seems to be a very strong model at medical reasoning.