Daryssi

Copper Tripeptides as cure to Balding? GHK-cu and it's analogs (like AHK-cu) seem extremely promising for hairloss, not only because they: - increase hair follicle size itself by stimulating DPC's - prolong the Anagen (growth) phase - stimulate blood flow in scalp through VEGF but also because they are very potent at increasing gene expression of matrix metalloproteins MMP1 and MMP2 these proteins not only put a halt to fibrosis (scar tissue formation) but also reverse it. What's interesting is that GHK-cu also increased expression of TIMP1, which inhibits function of these MMP's, a negative correlation has been found between TIMP1 expression and androgenic alopecia, with TIMP1 levels being lower in men that are further on the Norwood scale. TIMP1 it's function is to prevent the excessive breakdown of fibrosis from MMP's because after all, fibrosis still functions as a 'healing' response to mitochondrial dysfunction in the scalp. The fact TIMP1 is lower and lower the balder you are means that there's a ton of scar tissue in the scalp that needs to be broken down, and the recruitment of these MMP's is essential for that process to occur. fibrosis is always present in ENERGETIC (not androgenic) alopecia, and the copper tripeptides show extremely promising evidence in preventing/reversing this scar tissue formation in the scalp and eventually balding, but it remains more of a regulatory effect, it's benefits do not originate from direct effects on the ECM, but rather in improvements of metabolic function through gene expression, which will actually prevent/reverse the entire scar tissue formation. Remember that the body itself cares more about mitochondrial function than your hairline, fibrosis in the scalp is a healing response, not the cause.