David Cook

Excited to announce the Cook Lab will be opening at the Ottawa Hospital Research Institute Jan 2024. We'll be focusing on intratumoural heterogeneity and therapy resistance in ovarian cancer Eager to work more with the ovarian cancer research community! cooklab.ca

Thanks University of Ottawa for highlighting our work to improve outcomes for women with gynecologic disease. March is Endometriosis Awareness Month and it means a lot to see this focus not just on the science, but the patients who drive it.

I just updated the scDiffEq Python API (v1.1.0) to include animated visualizations of simulations. You can generate GIFs (or still images) showing: - Temporal gene expression dynamics - UMAP projections of simulated trajectories During my PhD, I found animations like these useful in presentations. Available now in the latest release: scdiffeq.com/_tutorials/vis…

Excited to share our recent manuscript out at @Nature . @piraner and @majo__duran from @roybal_lab and @Mohamad_Abedi and @AdamChazin in David Baker's lab engineered synthetic receptors that sense natural and designer soluble cues. nature.com/articles/s4158…

@vlorenzi3 @RArgelaguet @biorxivpreprint @ceci_icoresi @LuzGarAl @roserventotormo @MarioniLab Wow amazing! I’ve been dying to see a study like this on mullerian development/regression. Can’t wait to read. Congrats!

📢Excited to share our work on @biorxivpreprint "Spatiotemporal map of the developing human reproductive tract at single-cell resolution"! Beyond grateful to our amazing team @ceci_icoresi @LuzGarAl @roserventotormo @MarioniLab and collaborators for their contributions. 🧵[1/10]

A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies. nature.com/articles/s4301…

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

@Kalzahrani071 @SRC_CRS Ahh!! Incredibly well deserved. Huge congrats! 🍾🎉

Thank you to @SRC_CRS for this incredible honour to cap of my training in cancer research! Looking forward to starting my own research program in the near future and hope to inspire the future Next Generation!

@c_mccloskey1 @SRC_CRS @OvarianCanada Woooohoo! Big congrats 🎉 🎉 Looking forward to seeing what you have in store! 👀

Extremely grateful to @SRC_CRS and @OvarianCanada for this mega support to hit the final milestones in training and towards starting my own research program!! Excited to tackle big questions in women’s cancer prevention and treatment with this funding 🔬 #OutsmartingCancer

1/🧵Excited to re-introduce Memento in (cell.com/cell/fulltext/…), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇

Interactive design and validation of antibody panels using single-cell RNA-seq atlases biorxiv.org/content/10.110…

snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives👏 nature.com/articles/s4200…

Happy publication day for us! Labor of love with @CoffmanLab #TLS #ovariancancer @UPMCHillmanCC @PittTweet The activity of tertiary lymphoid structures in high grade serous ovar... sciencedirect.com/science/articl…

🚀 Excited to share our new publication in @NatureBiotech! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details tinyurl.com/5f8vjhpp! (1/10)

STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging | bioRxiv ⁦@DrJasPlummer⁩ ⁦@hoheyn⁩ ⁦@pascual_reguant⁩ ⁦@eliseinsing⁩ ⁦@cnag_eu⁩ ⁦@ACEpigenetics⁩ ⁦@StJudeResearch⁩ biorxiv.org/content/10.110…

3D cellular CODA maps of the fallopian tube are used to guide the design of "assembloids" that recapitulate the complex architecture and ciliated-based motion of oocytes. See more here: science.org/doi/10.1126/sc…

FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics | Nature Methods nature.com/articles/s4159…

FixNCut: A Practical Guide to Sample Preservation by Reversible Fixation for Single Cell Assays bio-protocol.org/en/bpdetail?id…

(1/n) Excited to announce a new article with @rafalab @AviSahuAI describing our approach scDist for finding cell types with transcriptional changes between conditions in single-cell data! nature.com/articles/s4146…

@MILOLab2 @alissacg Looks awesome! Congrats!