David Yule

Discovery of new AMPA receptor regulators – RNA molecules that act as competitive antagonists causing CNS-related toxicity when intended for treatment of autosomal dominant polycystic kidney disease (ADPKD). Collaboration with Regulus Therapeutic/Novartis! nature.com/articles/s4146…

Delighted to receive copies of the (just published) book on statistics that @JakubTomek13 and I have written. Presents statistics and related experimental design without maths and jargon. Available from: amazon.com/Basic-Statisti… or wiley.com/en-us/Basic+St…

Happy to share the locking mechanism of human oncochannel TRPV6 inhibition by intracellular magnesium. Amazing collaboration with Chubanov and Efremov groups. #Sec23" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

Please read my reply physoc.onlinelibrary.wiley.com/doi/10.1113/JP… to Ole Petersen’s letter physoc.onlinelibrary.wiley.com/doi/10.1113/JP… to the Journal of Physiology regarding our paper physoc.onlinelibrary.wiley.com/doi/10.1113/JP… Open discussion is good for science.

Our Lab(@jyotitanwar1993, @Kriti_ahuja9090 & others) just returned from an exciting Lab retreat from Ranthambore National Park & Garadia Mahadev, Rajasthan! Our sincere gratitude to @EMBO Global Investigator Fellowship for funding support! Many thanks to @unescorcb @DBTIndia!

Structures of kainate receptor channel GluK2 in the apo closed and open conducting states, both with 2-fold symmetrical LBD layer. To open the channel, we used agonist kainate and positive allosteric modulator BPAM but no Concanavalin A! @shantigangwar nature.com/articles/s4159…

Excited for our study in NAR, "ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis". The first of a couple of collaborative studies that demonstrate the potential of ACE-tRNAs as a platform therapeutic. academic.oup.com/nar/article/53…

Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @conn_pann_fun and Xiang Lab. @ucdavis, @UCDAVISPharmac1, @UCDavisHealth. ahajournals.org/doi/10.1161/CI…

Loss of the calcium sensor #STIM2, but not of STIM1, worsens #ColorectalCancer growth and metastasis by boosting calcium ion content in the endoplasmic reticulum, remodeling mitochondria, and rewiring transcriptional activity. @TrebakM @Trayambak_P scim.ag/44v3O3E

Check out our new paper. A great collaboration between the Yule, Orlandi and Groblewski labs:physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

@JLS_Lab @rizzutolab @DavidYule64 Planning for European Calcium Society Main Meeting (ECS2026) by Khaled Machaca & team in Doha, Qatar is in full swing with most speakers confirmed. Meeting website for updates: qatar-weill.cornell.edu/event/imecs/sp… The meeting will be held at Sheraton Doha from Feb 1-4, 2026. @EuroCalcium

New paper from the lab in press in JBC. Please check it out. jbc.org/article/S0021-…

Postdoctoral position available in the Lab focusing on the cellular regulation of calcium signaling pathways during cell division and differention. If interested please apply at the below link. wcmq-academicpositions.odoo.com/jobs/postdocto…

Last week @adamsgreenstein and I had the honour and surprise of winning the @TheBHF Research Story of the Year award. The award was based off our work published last year in PNAS, and was only possible due to an amazing group of scientist at @OfficialUoM and @GJBrainResearch

Our new review: check it out! pubmed.ncbi.nlm.nih.gov/39591657/

Check out our study published in NAR. #nonsense #tRNA Optimization of ACE-tRNAs function in translation for suppression of nonsense mutations academic.oup.com/nar/article/do…

Animated summary of our study published in @PLOSBiology journal by a highly talented and motivated PhD scholar @Kriti_ahuja9090! Paper's link: journals.plos.org/plosbiology/ar… @NatureInd @IndiaBioscience @SciComm_India @unescorcb @DBTIndia @India_Alliance

THE POST BELLOW HAS TRIGGERED MORE REPUBLICAN AND MAGA RESPONSES ATTACKING IT, AND ATTACKING ME PERSONALLY THAN NEARLY ANY ANTI-TRUMP ATTACK I HAVE POSTED IN THE PAST 2 YEARS. IT APPEARS TO HAVE STRUCK A NERVE.

Great opportunity!

Mapping the detailed architecture of Ca2⁺ tunneling and modulating its function using a novel tunneling inhibitor show that tunneling enhances Cl⁻ secretion in cells and sweating in vivo. New from Courjaret, @kmachaca et al. @WCMQatar: hubs.la/Q02X6vQv0 #Physiology