Dermal Cell News

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The authors explore the mechanistic underpinnings of senescence in skin, the evidence for both therapeutic approaches, and the future directions for integrating senotherapeutics into regenerative and aesthetic #dermatology. 📖 @GeroScienceAGE | bit.ly/4btMHlZ

Researchers identify keratinocyte-derived Wnt5a as a driver of complex regional pain syndrome, promoting pain hypersensitivity through NR2B and MMP9 signaling. bit.ly/4wfJCP3

Researchers identify dermal papillary fibroblasts as key drivers of persistent granulation tissue formation in junctional epidermolysis bullosa, revealing TGFβ signaling as a promising therapeutic target. 📝 bit.ly/44mjSnD

A research team from NOVA University Lisbon enhanced bacterial cellulose wound dressings 🧫🩹 with FucoPol, boosting #keratinocyte activity and accelerating wound closure for improved skin repair. Learn more at @ACSPublications: bit.ly/4f4VgF1

Scientists showed that chemotactic self-organization governs mammalian hair follicle patterning, explaining how distinct hair patterns emerge across species. Discover more at @PNASNews: 🔖 bit.ly/44gbaaE

Matthew Hunt at Karolinska Institutet is one of the recipients of the IBSA Foundation Fellowships 2025. He is awarded the fellowship for a research project on new treatment strategies for aggressive skin cancer. ▶️ bit.ly/4gVSkwL

This @cddpress investigation characterized ubiquitin‑specific peptidase 5 (USP5) using proteomic, biochemical, and functional approaches. USP5 was upregulated in #melanoma and promoted proliferation, migration, and invasion. 📚 go.nature.com/4v9bBhK

Congratulations to the @kalhorlab!👏 @JohnsHopkins scientists develop 3DEEP, a tissue-clearing approach that removes genomic DNA to extend spatial transcriptomic profiling hundreds of microns into intact tissues. bit.ly/3Te9tIa They applied 3DEEP to neonatal mouse skin, capturing hundreds of developing #HairFollicles across their organogenesis trajectory. 🧬

This review out of Siksha 'O' Anusandhan highlights emerging trends in #nanotechnology-driven approaches for #WoundHealing, with a focus on their design and therapeutic potential across different stages of wound repair. 📖 Give it a read: bit.ly/4aGGPpl

A new @acsnano study reveals that #keratinocyte-derived nanovehicles can not only enhance the accumulation of calcipotriol in #DendriticCells (DCs), but also synergistically reprogram DCs. #Psoriasis Learn more from Zhejiang University researchers. 👇 bit.ly/4oA8VIs

This study led by Dr. Marc Lavertu evaluated a #chitosan-fibrinogen-thrombin matrix enriched with autologous skin cells and a fatty acid sodium salt to enhance wound closure and regeneration. go.nature.com/4xUjomb Mechanical testing showed wound thickness and resistance similar to native skin, suggesting near-functional recovery despite incomplete maturation.

Scientists highlight emerging nanotechnology-based drug delivery strategies that enable targeted, controlled, and multifunctional therapies to improve wound healing and tissue regeneration. ▶️ bit.ly/4aGGPpl

Researchers develop a hair follicle–derived mouse model of Merkel cell carcinoma, revealing how MCPyV small T antigen and p53 loss drive tumor initiation and metastasis. 🔖 bit.ly/4vsAQfV

In this study, investigators at @KU_Leuven uncover DDERMMAL as a key regulator of the DNA damage response in melanoma, enabling tumor cells to survive genetic stress and therapy. ▶️ bit.ly/44xlXwU

Scientists develop ionic liquid–coated nanoparticles for topical delivery of honokiol, enhancing hair regrowth by remodeling the follicular microenvironment and activating Wnt/β-catenin signaling in androgenic alopecia. 📝 bit.ly/4w5by7s

Scientists show that DNA hydrogel-delivered hypoxic stem cell exosomes accelerate repair of radiation-induced skin injury by stabilizing AKT signaling through the miR-486-5p/RNF213 axis. 📝 bit.ly/3QWOqcs

Scientists from China Medical University explored whether #Hypoxia-inducible factor-1α (HIF-1α) modulates #Ferroptosis-associated senescence in human #DermalFibroblasts. bit.ly/43MZThD Targeting the HIF-1α/NF-κB/DPP4 axis may represent a potential strategy for mitigating skin aging. 🎯

🆕 New in @cddpress! Dr. Tianshun Zhang and @UMNews collaborators identify CD70 as a stress-inducible signaling hub that links DNA damage, inflammation, and tumor–stromal communication in #SkinCarcinogenesis. 🗣️ 🔗 go.nature.com/4fVw3Ph

#Keratinocyte-derived nanovehicles can not only enhance the accumulation of calcipotriol in #DendriticCells (DCs) but also synergistically reprogram DCs, providing a strategy for treating immune-mediated skin disease. 💡Learn more: bit.ly/4oA8VIs

Dr. Aneta Skaradzińska and co-authors provides an overview of current advances in #bacteriophage-based approaches for the treatment of cutaneous infections and #SkinDisorders. #OpenAccess 🔓 🔗 bit.ly/4gmCH15