Dermal Cell News

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Scientists reveal that DUSP1 protects human dermal fibroblasts from UVB-induced photoaging by regulating ferroptosis. ☀️ 🔗 bit.ly/48X3A7A

Investigators identify GD3 synthase as a key driver of melanoma progression through lipid metabolism reprogramming. Discover more here: bit.ly/4f4PtAF

A new review highlights how T cell immunosenescence fuels chronic inflammatory skin diseases like psoriasis, atopic dermatitis, rosacea, and seborrheic #dermatitis. Read more here: 📖 bit.ly/49bAst6

🔬 Researchers show that BLK suppresses melanoma progression by promoting pyroptosis and enhancing anti-tumor immune responses, improving sensitivity to immunotherapy. 🔖 go.nature.com/48OLnZO

Learn how to dissociate PSC-derived #epithelial cultures grown in 2D/3D formats into single cells with this collection of optimized protocols from @STEMCELLTech. 📃 bit.ly/4eBRrIG

Researchers including Dr. Kaiming Zhang and Jianxiao Xing demonstrated that elevated actin-associated protein 3 (ACTR3) expression in cutaneous tumors and #psoriasis promotes abnormal #keratinocyte proliferation in psoriasis. 🆕 bit.ly/3PvS9gm

This #OpenAccess @ScienceAdvances study reveals distinct splicing preferences associated with SF3B1 mutations and highlights NF1 missplicing and RAS activation as critical drivers of SF3B1R625 mutation-mediated #Melanoma. 🔗 Give it a read: bit.ly/4niGBJW

This @CommsBio study, led by Drs. Carlos Figueiredo introduces a syngeneic preclinical model that mimics the immunosuppressive landscape of BAP1-deficient melanocytic tumors, enabling the development of new combination immunotherapies. 📖 go.nature.com/4nc34Iy

A team out of Peking University (@PKU1898) uncovers a mechanism by which GD3 synthase modulates aberrant lipid metabolism and promotes the progression of #melanoma. 📖 Abstract: bit.ly/4f4PtAF

🆕 New from Central South University! This review explores the role of T cell #immunosenescence in the pathogenesis of common inflammatory skin diseases, including #psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis. 🔗 Give it a read: bit.ly/49bAst6

A research team demonstrated that BIRC5 promotes #keratinocyte proliferation and survival by suppressing autophagy via the PI3K/AKT/mTOR pathway, contributing to #psoriasis progression. go.nature.com/4uj04wa

Researchers alongside Dr. Hamid-Reza Rezvani show that DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by inducing tumor cell differentiation through disruption of cellular redox balance. 🔖 go.nature.com/4uaTk3q

A local sympathetic-immune axis inhibits melanoma growth! Researchers performed optical reconstruction of axonal innervation in mouse models of cutaneous melanoma, revealing progressive innervation by sympathetic axons. 💡 bit.ly/4un2Pgg

Researchers alongside Dr. Luca Pontiggia at the University Children’s Hospital Zurich show that radial constraint prevents shrinkage in engineered skin substitutes, improving structural integrity and reproducibility for skin graft development. 🔖 bit.ly/4cnblEy

Researchers from @UCSF alongside Dr. Hunter Shain (@ShainLab) show that somatic mutations define distinct melanocyte subpopulations in human skin, with low-mutation, stem-like cells helping replenish UV-damaged epidermis. 🔖 go.nature.com/4tE5W3r

Researchers show that potassium transport via Trk1 is essential for Candida auris skin colonization, identifying a potential target to combat this emerging pathogen. ▶️ bit.ly/4cLPOWa

Dr. Abbas Shafiee and Imaan Ahmed from the University of Queensland highlight advances in hair regeneration using #organoids and hair-on-chip technologies, offering new strategies to model and restore human hair growth. ▶️ rsc.li/41VZ59g

Researchers develop a targeted nanogel delivering naringenin to skin cancer cells, enhancing uptake while reducing UV-induced oxidative stress and inflammation. bit.ly/41OeEzK

The crucial role of C1s in cancer progression! Scientists investigated the mechanistic role of C1s in regulating apoptosis by examining its impact on cell surface proteome of cutaneous squamous cell carcinoma cells. go.nature.com/4cDOne5

Investigators show that papillary and reticular fibroblasts play distinct roles in skin aging, with papillary fibroblasts supporting stronger barrier integrity and reticular fibroblasts linked to barrier decline. 🔗 go.nature.com/3ON525p