Simeon Crawford

Bacterial and fungal infections in persons who inject drugs pubmed.ncbi.nlm.nih.gov/40511913/ 💉 5 stars; you'll want this one. @MayoClinicINFD @LauraMarks5

In @OFIDJournal, Jeffrey Masters, MBBS, and colleagues characterize population-level injecting-related infection hospitalization and correlates associated with patient-directed discharge, readmission, and all-cause mortality among PWID with hepatitis C. bit.ly/4k0dS9U

Medicine has made many amazing advances over the past half century. One is around drug development and improving pharmaceutical options. Another is around allergy testing. People can be allergic to a wide range of things. Allergies can also range in severity from serious life threatening ones (anaphylaxis) to milder forms like skin rashes. There are now a variety of ways to perform allergy testing. As a kid less than 5yo, I was pretty scrawny and had recurrent episodes of #tonsillitis and other infectious illnesses. I think I developed a skin rash when I was on #penicillin and it was thought to be an #allergy. Drugs (including penicillins) have changed over the past 50 years; it was recently recommended to me by an expert that I be formally tested now to see if my allergy to #penicillin as a child still persists with modern forms of penicillins. The idea was that if/when my #glioblastoma goes downhill, penicillin #antibiotics may be a handy “tool in the tool shed”! After controlled testing by an expert allergy #immunologist, it was concluded that I’m safe to take modern penicillin! Fingers crossed 🤞 I don’t need it! @SydneyLHD @USyd

@DrToddLee @mykkymcg absolutely. What does /clav get you in the context of recommending adding azithro or doxy? I used SENTRY data to get the table below. In the context of putative amp-R pneumococcus or something else amox might not cover, what is the benefit?

Make it make sense - why is amoxicillin 1000mg TID for CAP but Augmentin is 875/125 BID. The clav is expanding the spectrum not making it more active against Strep pneumo. Sicker patient, give lower dose vs most significant pathogen. Got it.

Great to see we have a low rate of post-transplant SSI with amox/clav prophylaxis

Without a brain biopsy and metagenomic sequencing, we would have never known the etiology of this patient's subacute, worsening encephalitis. #Dengue #HIV #viralencephalitis

@ZaydNAhmad @ABsteward @NEJM @asap_trial @DrTrishaPeel @peripatetical @davidantibiotic Results were presented in a webinar and panel discussion last week, recording available on YouTube. Many of these questions were addressed. m.youtube.com/watch?v=q2DbhO…

@ABsteward @NEJM @asap_trial @DrTrishaPeel @peripatetical @davidantibiotic Bizarre results. Adding vanco shouldn’t increase risk of infection and it’s certainly not renal protective.

🔥🔥 ASAP RCT 🔥🔥 @NEJM The addition of vancomycin to cefazolin prophylaxis was not superior to placebo for the prevention of SSIs in arthroplasty among patients without known MRSA colonization ⬆SSI with combo after TKA ⬇AKI with Vanco/CFZ #IDXposts nejm.org/doi/full/10.10…

@marinelli_tina Does pouring Listerine into the wound help?

Step #2, worry about all the bacteria (Salmonella) inoculated by the bite

Fun fact from the ZOOSIG excursion to Adelaide Zoo: if being bitten by a Komodo dragon, pour listerine on it’s nose to get it to release @ASIDANZ

Is there a role for TDM with beta-lactams? Faculty @CasausDanielle, @IDPharmD_Kate & @Veena_PharmD discuss TDM of pip-tazo & clinical outcomes in septic pts in our latest SIDP Journal Club Series (sidp.org/BCIDP), worth 1.5h of ACPE/BCIDP credit! #IDtwitter #TwitteRx

Would you proceed to transplant a patient with acute, mild COVID-19? We present a challenging case of acute liver failure with concomitant SARS-CoV-2 who underwent OLT and highlight key management considerations. @RachaelJacob10 @TheTxIDjournal doi.org/10.1111/tid.13…

Probs one of the best review articles I've read. @DrLuisO @ClancyNeil @FungalDoc @DrPappasID , DPK , @ElMylonakis

Shorter. Is. Better. jamanetwork.com/journals/jamao…