@AliTaherMD @beneitez_david @AUBMC_Official @AUB_Lebanon @AUB_FM @drKMusallam @ChronicCareCntr @thalassaemiaTIF Very exciting and important Ali, and congratulations to all!
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The Drakesmith Lab
504 posts
The Drakesmith Lab
@Drakesmith_Lab
Welcome to the @UniofOxford iron lab! Based in the @MRC_WIMM @MRC_TIDU we research the involvement of iron in immunity and pathogenesis.
Oxford, England Katılım Aralık 2018
559 Takip Edilen1.1K Takipçiler
Thrilled to share that our global Phase 3 trial of mitapivat in NTDT—where I served as global PI & lead author—has been accepted in The Lancet!
A game changer: the first oral disease-modifying therapy in NTDT. Proud this was led from #Lebanon.
🔗 sciencedirect.com/science/articl…
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Two new contributions from us: @MeganRTeh on the wild metabolism of CD8 T-cells in iron deficiency and why they love aspartate; and the current landscape of the strong influence of iron on immunity in general, with @JoeNFrost
nature.com/articles/s4157…
nature.com/articles/s4146…
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Exciting paper for the iron field! nature.com/articles/s4158…
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Wonderful to see this out, a big effort led by @AE_Preston and fun for the lab to do something new (and very very old) nature.com/articles/s4146…
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Thrilled to share our latest work on how the non-essential amino acid #asparagine metabolically regulates germinal centers. Huge thanks to my PhD supervisor @a_j_clarke, colleagues, and collaborators at the @KirOxford @UniofOxford, and @TheCrick who made this possible!
Science Immunology@SciImmunology
Researchers have identified #asparagine metabolism as a key regulator of #GerminalCenter B cell function in mice. @UniofOxford @a_j_clarke @YavuzYaziciogl1 Read more in Science #Immunology: scim.ag/4gxYTlN
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Excited to finally share this intriguing discovery that has mechanistically perplexed our group for years. Led by Alex (@CincyMSTP) & @RachLCan22 of @CincyImmunology w/ #PalumboLab, we find that prothrombin prevent fatal T cell-dependent hemolytic anemia during virus infection
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@ChristianGPeace @shaneOCarroll4 @laoneill111 @NatMetabolism Very nice @ChristianGPeace ! Congratulations
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Excited to share a new paper from my PhD work along with @shaneOCarroll4 from the @laoneill111 lab on how the metabolite itaconate regulates IFN, out today in @NatMetabolism (nature.com/articles/s4225…)
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Getting tooled up with props for this! @World_of_Wade @OxUniEarthSci will bring his rocks
MRC WIMM@MRC_WIMM
Don't forget to book your tickets for IRONCLAD (14 October), a 4.6 billion-year whistle-stop tour of events covering the formation of our planetary home, the evolution of complex life, and iron’s role in driving infections and illnesses. Book here: eventbrite.co.uk/e/ironclad-reg… Hal Drakesmith, Professor of Iron Biology in the @MRC_TIDU, and Jon Wade, Professor of Planetary Materials @OxUniEarthSci, will bring to life the story of iron, a crucial element fundamental to your world.
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@RalserLab Reviewing seems slower. Don’t know why. This isn’t directly relevant but is 👀 reuters.com/legal/litigati…
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Preprints brought hughe improvements to scholarly publishing, but it seems to me they further slowed down peer review. That's not a for quality - it may even improve it - but it could put more challanges on early career scientists that need the papers out. Same impression anyone?
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Looking forward to doing a thing with @World_of_Wade ! Watch out for meteorites
RDM Oxford@RDMOxford
IF Oxford – the science and ideas festival – returns in October 2024 💡 Pick from pioneering performances, hands-on experiments, interactive events and more. RDM is involved in three events this year! 🎉 Read more about our events 👇 shorturl.at/ToZOW #IFOxford2024
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The Drakesmith Lab retweetledi
Hemochromatosis C282Y homozygotes had an increased risk of any infection and a markedly increased risk of sepsis and death from infections. ow.ly/zIZT50SYKPJ #plenarypaper #clinicaltrialsandobservations #redcellsironanderythropoiesis
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The Drakesmith Lab retweetledi
The iron curve: infection at both ends
ashpublications.org/blood/article/…
Hypoferremia and hyperferremia were both associated with #infection risk🐛
@Drakesmith_Lab
@acweyand @Iron_Deficiency #iron #anemia @IronResearchLab @ironoverloadUS @BloodNet_PALISI #PedsICU @AABB #transfusion
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The Drakesmith Lab retweetledi
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Why cells need iron: a compendium of iron utilisation sciencedirect.com/science/articl…
Superb review by Megan Teh, Andrew Armitage, and Hal Drakesmith. Thank you very much for such massive work!
@BioIronSocial @eic2022 @Drakesmith_Lab
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@Drakesmith_Lab @MeganRTeh Congratulations - a tour de force. What a fantastic resource for anyone interested in human iron biochemistry!
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Iron deficiency is highly prevalent worldwide but how it manifests at molecular/cellular levels is poorly understood. The brainchild of @MeganRTeh our new review is a compendium of why cells need iron and what happens when there isn’t enough! sciencedirect.com/science/articl…
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@Susannajd @CGHRinfo Wonderful! Many congratulations and they’re lucky to have you!
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Honoured to take up this role - @CGHRinfo is a centre for partnerships around the world supporting research, training and multi-directional learning to improve the health of people in resource limited settings. Proud to work with many talented people near and far.
Tropical Medicine Oxford@TropMedOxford
Congratulations Susanna Dunachie @SusannajdNDM, recently nominated Director of the NDM Centre for Global Health Research @CGHRinfo @MORUBKK @OUCRU_Programme @KEMRI_Wellcome tropicalmedicine.ox.ac.uk/news/ndm-cghr-…
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