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@DrugNerd1

Science guy for pharma co. Bills fan. Nature fan. Sabres fan.

Rochester, NY Katılım Aralık 2016
199 Takip Edilen178 Takipçiler
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Polymarket
Polymarket@Polymarket·
NEW: Study reveals LinkedIn is the most AI-saturated major social platform, with over 40% of long-form posts flagged as fully AI-generated “slop.”
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Wall Street Apes
Wall Street Apes@WallStreetApes·
This family checked into an Airbnb in San Diego, California They look at this well and there is a large picture of people at the beach. The dad looks at it and says, “That looks like me” about a guy in the water The picture is of them, the girls, the dad, the whole family is at the beach playing in the water in this painting on the wall of the Airbnb they just checked into According to AI, the odds of this happening are so extremely low it’s hard to comprehend The odds are 1 in hundreds of millions for a random booking to have this picture of you
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Elena
Elena@VirtualElena·
the barbellificiafion of society also means we’re exiting the era of the “everything” city (eg nyc, london) and entering the era of the specialized, industry-specific city (sf, dc, taipei, maybe la if it gets its act together and turns into an ai entertainment boomtown). you shouldnt be hedging in the variety store, you cannot languish in the pleasure dome. pick a city and allocate all your time and attention and relationships there. or become irrelevant.
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CJ Gillman
CJ Gillman@CoachGilly6·
This is it, this is why I can’t watch.
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Austin Lieberman
Austin Lieberman@LiebermanAustin·
Thanks to the @oasishealthapp I’ve switched from poisonous FairLife Protein Milk to Bourbon and I can’t even begin to explain how much healthier I feel.
Austin Lieberman tweet mediaAustin Lieberman tweet media
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GB
GB@DrugNerd1·
When people lose 15% to 20% of their body weight rapidly, they often face significant skin laxity and volume loss. This will create a secondary wave of demand for body contouring and volume-restoration procedures. $ESTA stands to benefit from this tailwind. Known for their next-gen Motiva breast implants and Mia Femtech minimally invasive procedures, I believe they will capture a large portion of post-GLP-1 patients looking to restore natural contours.
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Donny Dreamboat
Donny Dreamboat@deathbycontent·
Martin St. Louis at Canadiens practice today
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Derek Heid
Derek Heid@DerekHeid·
A Lewiston artist has a unique role in the Buffalo Sabres' Stanley Cup playoff run After every win, the team adds a puck to a custom-made ‘playoff puck holder’ crafted by Dan Buttery at Black Lab Metal Fab #sabrehood @WKBW @dbuttery665 wkbw.com/niagara-county…
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Barstool Sports
Barstool Sports@barstoolsports·
Josh Allen gets Game 2 started King of the North!
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GB
GB@DrugNerd1·
@adamfeuerstein the only value in the ct prediction market that I see is it enables more bets b/c it allows you to bet on isolated events w/o exposure to the underlying investment that's subject to many other forces you might not be interested in speculating on.
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GB
GB@DrugNerd1·
@Jason Think of the biscuits though
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@jason
@jason@Jason·
Incompetent private equity dudes buying a terrible restaurant chain and blowing it up is meaningless in a vibrant economy because all those customers and workers move to a better offering. And it’s not hard to make a better offering than Red Lobster Stop worrying about the free market and stop the 30% fraud in government @ewarren!
Elizabeth Warren@ewarren

If anyone looked right beneath the surface, they’d be able to see that Red Lobster’s real downfall was not offering endless shrimp — it was private equity’s endless greed.

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Year of Glad
Year of Glad@pemulisking·
I wonder if TBPN will be able to maintain their same standard of hard-hitting, critical journalism now that they're owned by OpenAI
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GB
GB@DrugNerd1·
@ResearchPulse1 Gonna take the other side of this. What matters is what the sales reps can say to HCPs w/o fear of repercussions. They can say take w/o regard to food w/ orfo. W/ wegovy they have to say empty stomach.
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ResearchPulse
ResearchPulse@ResearchPulse1·
$LLY arguments that there’s no restrictions for when to take Orforglipron/ FOUNDAYO and no fasting either. Then take a look at warning for drug interactions…….. Avoid concomitant With CYP3A4 Inducers. Because that will reduce the effect of Orforglipron……. That means you need to take higher dose to reach same effect. Okay. What contains CYP3A4 Inducers? Many dietary supplements and herbal remedies can affect the CYP3A4 enzyme. St. John's Wort (Johannesurt): Often used in teas, capsules, and extracts. Echinacea. Frequently used in products for the common cold. Garlic. Specifically in the form of concentrated garlic extracts or high-dose supplements. Ginseng: Various types, such as Panax ginseng, are commonly studied in relation to metabolism. Coleus forskohlii: Sometimes found in weight management supplements. Ashwagandha and Oregano: Often found in botanical extracts. Certain in vitro studies have shown over 50% induction of enzyme activity for these botanical extracts. Vitamin D3: Generally discussed in the context of high-dose supplementation. Curcumin (Turmeric): A common spice and supplement extract. There’s also many different medicine that induce CYP3A4 Rifampin Antibiotic (Tuberculosis/Leprosy) St. John's Wort Herbal supplement (Depression) Phenytoin Anticonvulsant (Seizures/Epilepsy) Carbamazepine Anticonvulsant & Nerve pain Phenobarbital Sedative & Anticonvulsant Glucocorticoids Steroids (Inflammation/Arthritis) Corticosteroids Anti-inflammatory medication There’s a TON of supplements and medications that can reduce the effect of Orforglipron. LLY saying there’s NO restriction (on what and when you drink/eat/medicine) when in fact there’s a long an unknown list of things NOT to take within xxx window of taking Orforglipron…… With wegovy pill it’s simple. Take on empty stomach when you wake up and don’t eat/drink for 30 minutes. How will you as a doctor tell your new Orforglipron patient what not to take before/toghther/after….? And what effect it will have if you do so? $NVO $VKTX
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ResearchPulse@ResearchPulse1

Orforglipron/ FOUNDAYO Do you remember when $NVO ceo at JPM said there would be warning for certain statins when using Orforglipron? A few hours later $LLY CEO said there was no such thing in the coming label. Now take a look at the label and warning for drug interactions. If you use higher dose than 20mg Simvastatin you can NOT use Orforglipron…… About 6.5 million Americans use Simvastatin. About 40% on higher dose than 20mg $VKTX

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JAMA Psychiatry
JAMA Psychiatry@JAMAPsych·
In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/4uTZlTo
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orph
orph@orphcorp·
you can observe where the interests of patient vs healthcare system diverge when it comes to parallel vs serial treatment practitioners will often insist on sequential treatment (unless there are tested parallel protocols) for various reasons, incl. causal attribution & liability minimization — they have little incentive to parallelize, even if it is at the cost of patient outcomes yet the patient doesn't need to know what cures them! they just want to be cured!
owl@owl_posting

‘we don’t need to know what cured you’ has permanently updated my understanding of what ideal cancer care should look like. there's a distinct sense of nausea and excitement that accompanies knowledge that you feel like you should’ve understood years back. excellent presentation

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Eyal Yakoby
Eyal Yakoby@EYakoby·
BREAKING: In NYC at the “No Kings” rally, demonstrators waved Communist flags. No kings, but yes Communist dictators.
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The Buffalo News
The Buffalo News@TheBuffaloNews·
The top leadership of the Ralph Wilson Park Conservancy resigned in the last few weeks, leaving the nonprofit with no staff and only an acting chairman just months before the $250M public park is slated to begin reopening on Buffalo's Lower West Side. buffalonews.com/news/local/art…
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